Induction of Cellular Senescence by Androgen Receptor Agonist or Antagonist Is Mediated via Two Novel Common DYRK1A-DREAM and Cyclin G2 Signaling Pathways in Castration-Resistant Prostate Cancer

Investigators presented the identification of two common and independently acting pathways induced by AR-antagonists and supraphysiological androgen levels, used in bipolar androgen therapy, to mediate growth inhibition and induction of cellular senescence in CRPC.