Inducible CD147 Up-Regulation Boosts Extended SARS-CoV-2 Infection Triggering Severe COVID-19 Independent of ACE2

Researchers found that SARS-CoV-2 infection boosts CD147 inducible up-regulation in the lung tissues of virus-infected rhesus macaques coupled with down-regulated membrane-bound ACE2, which conduces to extended virus infection and severe pathological lesions.