Astrocyte Plasticity in Mice Ensures Continued Endfoot Coverage of Cerebral Blood Vessels Following Injury and Declines with Age

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The authors investigated if focal ablation of astrocytes were sufficient to disrupt the blood-brain barrier in mice. Targeted two-photon chemical apoptotic ablation of astrocytes induced a plasticity response whereby surrounding astrocytes extended processes to cover vascular vacancies.
[Nature Communications]
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