The Natural Antisense Transcript HAS2-AS1 Regulates Breast Cancer Cells Aggressiveness Independently from Hyaluronan Metabolism

Scientists reported that estrogen receptor (ER)-positive breast cancers had lower hyaluronan synthase 2 antisense RNA 1 (HAS2-AS1) expression compared to ER-negative tumors. Moreover, the survival of patients with ER-negative tumors was higher when the expression of HAS2-AS1 was elevated.
[Matrix Biology]
Abstract
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