Dipyridophenazine iridium(III) Complex as a Phototoxic Cancer Stem Cell Selective, Mitochondria Targeting Agent

The remarkable activity of complex 1 was observed not only in rhabdomyosarcoma cells cultured in 2D monolayers but, more importantly, also in 3D spheroids, which resembled in many aspects solid tumors and served as a promising model to mimic the in vivo situation.