Galectin-1 Orchestrates an Inflammatory Tumor-Stroma Crosstalk in Hepatoma by Enhancing TNFR1 Protein Stability and Signaling in Carcinoma-Associated Fibroblasts

Scientists uncovered a crucial role of Galectin-1 (Gal-1) in carcinoma-associated fibroblasts that orchestrated an inflammatory CSC niche supporting hepatocellular carcinoma (HCC) progression and demonstrate that targeting Gal-1 could be a potential therapy for fibrosis-related HCC.