NAC1 Transcriptional Activation of LDHA Induces Hepatitis B Virus Immune Evasion Leading to Cirrhosis and Hepatocellular Carcinoma Development

In vitro, researchers investigated the impact of nucleus accumbens associated 1 (NAC1) and LDHA on immune cell apoptosis and hepatitis B virus (HBV) immune evasion. In vivo, they confirmed these findings using an HBV-induced cirrhosis model.