Co-Emergence of Cardiac and Gut Tissues Promotes Cardiomyocyte Maturation within Human iPSC-Derived Organoids

The authors described a human multilineage iPSC-derived organoid that recapitulated cooperative cardiac and gut development and maturation, with extensive cellular and structural complexity in both tissues.
[Cell Stem Cell]
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Mapping the Temporal and Spatial Dynamics of the Human Endometrium In Vivo and In Vitro

Benchmark of the endometrial organoids revealed the pathways and cell states regulating differentiation of the secretory and ciliated lineages both in vivo and in vitro.
[Nature Genetics]
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Mouse Lung Organoid Responses to Reduced, Increased, and Cyclic Stretch

To address limitations in cell culture and in vivo mechanotransductive models, scientists developed two mouse lung organoid mechanotransductive models using postnatal day five mouse lung CD326-positive cells and fibroblasts subjected to increased, decreased, and cyclic strain.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Microfluidic Organ-on-Chip System for Multi-Analyte Monitoring of Metabolites in 3D Cell Cultures

Investigators developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.
[Lab On A Chip]
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Patient-Derived Organoids as a Preclinical Platform for Precision Medicine in Colorectal Cancer

The authors investigated whether drug responses of organoids correlated with clinical responses of matched patients and disease progression of patients.
[Molecular Oncology]
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Harnessing Cerebral Organoids for Alzheimer’s Disease Research

Scientists review the most recent advances in modeling Alzheimer’s disease in organoids and other engineered 3D cell culture systems.
[Current Opinion in Neurobiology]
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Human Meibomian Gland Epithelial Cell Culture Models: Current Progress, Challenges, and Future Directions

In serum-free medium, rosiglitazone, a peroxisome proliferator activator receptor-γ agonist, was reported to induce immortalised human meibomian gland epithelia cell differentiation, neutral lipid accumulation and expression of key biomarkers of differentiation.
[Ocular Surface]
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Chinook Therapeutics Announces Formation of SanReno Therapeutics, a Joint Venture to Develop Kidney Disease Therapies in China

Chinook Therapeutics, Inc. announced the formation of SanReno Therapeutics, a joint venture with an investor syndicate led by Frazier Healthcare Partners and Pivotal bioVenture Partners China, to develop, manufacture and commercialize kidney disease therapies in the People’s Republic of China, Hong Kong, Macau, Taiwan and Singapore.
[Chinook Therapeutics, Inc.]
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Mount Sinai Researchers Awarded $3.15 Million to Advance a Multidisciplinary Drug Development Platform for Hepatocellular Carcinoma

The National Cancer Institute has awarded Mount Sinai researchers $3.15 million in grant funding to assess the potential of a multidisciplinary drug development platform to identify new biological targets for precision-based therapeutics for hepatocellular carcinoma.
[Mount SInai]
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Aptamer-Mediated Doxorubicin Delivery Reduces HCC Burden in 3D Organoids Model

Investigators developed a specific aptamer against EpCAM and tested its potential as a drug delivery agent for hepatocellular carcinoma.
[Journal of Controlled Release]
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SIRT1 Induces the Accumulation of TAMs at Colorectal Cancer Tumor Sites via the CXCR4/CXCL12 Axis

Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.
[Cellular Immunology]
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