The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells from Their Niche and Differentiation into Enterocyte vs Secretory Lineages

Scientists analyzed Notch regulation by examining expression profiles of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.
[Gastroenterology]
Baulies, A., Angelis, N., Foglizzo, V., Danielsen, E. T., Patel, H., Novellasdemunt, L., Kucharska, A., Carvalho, J., Nye, E., Coppi, P. D., & Li, V. S. W. (2020). The Transcription co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation into Enterocyte vs Secretory Lineages. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.06.012 Cite
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Enteroendocrine Dynamics – New Tools Reveal Hormonal Plasticity in the Gut

Researchers analyzed advantages and disadvantages of novel in vitro tools, adult stem cell or iPS-derived intestinal organoids, that have been crucial for recent findings on enteroendocrine development and plasticity.
[Endocrine Reviews]
Beumer, J., Gehart, H., & Clevers, H. (n.d.). Enteroendocrine dynamics – New tools reveal hormonal plasticity in the gut. Endocrine Reviews. https://doi.org/10.1210/endrev/bnaa018 Cite
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Human CNS Barrier-Forming Organoids With Cerebrospinal Fluid Production

Scientists established human choroid plexus organoids with a selective barrier and cerebrospinal fluid-like fluid secretion in self-contained compartments.
[Science]
Pellegrini, L., Bonfio, C., Chadwick, J., Begum, F., Skehel, M., & Lancaster, M. A. (2020). Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. https://doi.org/10.1126/science.aaz5626 Cite
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Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids

CRISPR/Cas9 gene editing introduced the OPTN(E50K) mutation into existing lines of human pluripotent stem cells, as well as generating isogenic controls from patient-derived lines.
[Stem Cell Reports]
Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids: Stem Cell Reports. (n.d.). Retrieved June 12, 2020, from https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(20)30181-8 Cite
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Wnt/β-Catenin Signaling Is Critical for Regenerative Potential of Distal Lung Epithelial Progenitor Cells in Homeostasis and Emphysema

Researchers identified an organoid‐forming adult distal lung epithelial progenitor cell population characterized by a low Wnt/β‐catenin activity, which was enriched in club and alveolar epithelial type (AT)II cells.
[Stem Cells]
Wnt/β‐catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema - Hu - - STEM CELLS - Wiley Online Library. (n.d.). Retrieved June 12, 2020, from https://stemcellsjournals.onlinelibrary.wiley.com/doi/10.1002/stem.3241 Cite
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Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons

Scientists used 2D and 3D human brain cultures to investigate methyl-CpG binding protein 2 (MeCP2) function. They found that MeCP2 mutations caused severe abnormalities in human interneurons.
[Molecular Cell]
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons: Molecular Cell. (n.d.). Retrieved June 12, 2020, from https://www.cell.com/molecular-cell/fulltext/S1097-2765(20)30317-8 Cite
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Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection

The authors showed that inducing surface strains of CeO2/Mn3O4 nanocrystals produced highly catalytic antioxidants that could protect tissue‐resident stem cells from irradiation‐induced ROS damage.
[Advanced Materials]
Epitaxially Strained CeO2/Mn3O4 Nanocrystals as an Enhanced Antioxidant for Radioprotection - Han - - Advanced Materials - Wiley Online Library. (n.d.). Retrieved June 12, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202001566 Cite
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A Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic Behavior

Investigators report that Epsin 3 is an oncogene with prognostic and therapeutic relevance in breast cancer.
[Nature Communications]
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