Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

The authors leveraged single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models to finely map the trajectories of alveolar-lineage cells during injury repair and lung regeneration.
[Cell Stem Cell]
Choi, J., Park, J.-E., Tsagkogeorga, G., Yanagita, M., Koo, B.-K., Han, N., & Lee, J.-H. (2020). Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.06.020 Cite
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Collective Cell Mechanics of Epithelial Shells with Organoid-Like Morphologies

Scientists propose a mechanistic theory of epithelial shells which resemble small-organoid morphologies. Using a 3D surface tension-based vertex model, they reproduced the characteristic shapes from branched and budded to invaginated structures.
[Nature Communications]
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Microbiota-Derived Metabolite Promotes HDAC3 Activity in the Gut

Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Remarkably, inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated HDAC3-dependent proliferation, and countered butyrate inhibition of colonic growth.
[Nature]
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Taming Human Brain Organoids One Cell at a Time

The authors summarize recent approaches, progresses and challenges in resolving brain organoid’s complexity through single-cell transcriptomics.
[Seminars in Cell & Developmental Biology]
Atamian, A., Cordón-Barris, L., & Quadrato, G. (2020). Taming human brain organoids one cell at a time. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.05.022 Cite
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Developmental GABA Polarity Switch and Neuronal Plasticity in Bioengineered Neuronal Organoids

The authors report the directed self-organization of human induced pluripotent stem cells in a collagen hydrogel towards a highly interconnected neuronal network at a macroscale tissue format.
[Nature Communications]
Zafeiriou, M.-P., Bao, G., Hudson, J., Halder, R., Blenkle, A., Schreiber, M.-K., Fischer, A., Schild, D., & Zimmermann, W.-H. (2020). Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nature Communications, 11(1), 3791. https://doi.org/10.1038/s41467-020-17521-w Cite
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Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids

Researchers presented a simple and minimally invasive fine-needle aspiration-based organoid culture technique using a variety of tumor types including gastrointestinal, thyroid, melanoma, and kidney.
[iScience]
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Patient-Derived Ovarian Cancer Organoids Capture the Genomic Profiles of Primary Tumors Applicable for Drug Sensitivity and Resistance Testing

Scientists developed expandable ovarian cancer organoids in less than three weeks; these organoids captured the characteristics of histological cancer subtypes and replicated the mutational landscape of the primary tumors.
[Scientific Reports]
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Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

The authors report a method to generate ureteric bud organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis.
[Cell Reports]
Mae, S.-I., Ryosaka, M., Sakamoto, S., Matsuse, K., Nozaki, A., Igami, M., Kabai, R., Watanabe, A., & Osafune, K. (2020). Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential. Cell Reports, 32(4). https://doi.org/10.1016/j.celrep.2020.107963 Cite
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miR-3622a-3p Acts as a Tumor Suppressor in Colorectal Cancer by Reducing Stemness Features and EMT through Targeting Spalt-Like Transcription Factor 4

The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
[Cell Death & Disease]
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Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma (LADC). Extensive gene and histopathology profiling show that the tumor organoids retain the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
[iScience]
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Pharmacogenomics of Aromatase Inhibitors in Postmenopausal Breast Cancer and Additional Mechanisms of Anastrozole Action

Estrogen receptor positive breast cancer organoids and aromatase inhibitor (AI)- or fulvestrant-resistant breast cancer cells were more sensitive to anastrozole plus estradiol than to AI alone.
[JCI Insight]
Cairns, J., Ingle, J. N., Dudenkov, T. T. M., Kalari, K. R., Carlson, E. E., Na, J., Buzdar, A. U., Robson, M. E., Ellis, M. J., Goss, P. E., Shepherd, L. E., Goodnature, B., Goetz, M. P., Weinshilboum, R. M., Li, H., Bari, M. G., & Wang, L. (2020). Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action. JCI Insight. https://doi.org/10.1172/jci.insight.137571 Cite
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
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