Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models

A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy]
Urbaniak, A., Reed, M. R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R. L., MacNicol, M. C., Chambers, T. C., & MacNicol, A. M. (2021). Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & Pharmacotherapy, 141, 111815. https://doi.org/10.1016/j.biopha.2021.111815 Cite
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BCL-XL Is Crucial for Progression through the Adenoma-to-Carcinoma Sequence of Colorectal Cancer

By targeting antiapoptotic proteins with specific BH3 mimetics in organoid models of colorectal cancer progression, scientists found that BCL-2 was essential only during instestinal stem cell transformation while MCL1 inhibition did not affect adenoma outgrowth.
[Cell Death & Differentiation]
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Self-Renewal and Differentiation of Rat Epididymal Basal Cells Using a Novel In Vitro Organoid Model

The authors isolated basal cells from the rat epididymis and established 3-dimensional cell cultures from the basal and non-basal cell fractions. Organoids were formed by single adult epididymal basal cells.
[Biology of Reproduction]
Pinel, L., & Cyr, D. G. (2021). Self-renewal and differentiation of rat Epididymal basal cells using a novel in vitro organoid model. Biology of Reproduction, ioab113. https://doi.org/10.1093/biolre/ioab113 Cite
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YAP/TAZ Suppress Drug Penetration into Hepatocellular Carcinoma via Stromal Activation

Multi-cellular hepatocellular carcinoma (HCC) organoid models were established which contained various types of stromal cells, such as hepatic stellate cells, fibroblasts, and endothelial cells together with HCC cells.
[Hepatology]
Cho, K., Ro, S. W., Lee, H. W., Moon, H., Han, S., Kim, H. R., Ahn, S. H., Park, J. Y., & Kim, D. Y. (n.d.). YAP/TAZ suppress drug penetration into hepatocellular carcinoma via stromal activation. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.32000 Cite
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Induction of Cell Death in Pancreatic Tumors by Zinc and Its Florescence Chelator TSQ

Upon treatment with N,N,N′,N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine, a zinc chelator, organoids degenerated and its negative effect was rescued by co-treatment with zinc, indicating that zinc is necessary for the growth and survival of tumor organoids.
[Biological Trace Element Research]
Asahina, K. (2021). Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ. Biological Trace Element Research. https://doi.org/10.1007/s12011-021-02770-7 Cite
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Generation of Functional Liver Organoids on Combining Hepatocytes and Cholangiocytes with Hepatobiliary Connections Ex Vivo

Scientists reported the generation of a hepatobiliary tubular organoid using mouse hepatocyte progenitors and cholangiocytes.
[Nature Communications]
Tanimizu, N., Ichinohe, N., Sasaki, Y., Itoh, T., Sudo, R., Yamaguchi, T., Katsuda, T., Ninomiya, T., Tokino, T., Ochiya, T., Miyajima, A., & Mitaka, T. (2021). Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nature Communications, 12(1), 3390. https://doi.org/10.1038/s41467-021-23575-1 Cite
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D-Dopachrome Tautomerase Contributes to Lung Epithelial Repair via Atypical Chemokine Receptor 3-Dependent Akt Signaling

Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.
[Ebiomedicine]
Song, S., Liu, B., Habibie, H., Bor, J. van den, Smit, M. J., Gosens, R., Wu, X., Brandsma, C.-A., Cool, R. H., Haisma, H. J., Poelarends, G. J., & Melgert, B. N. (2021). D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. EBioMedicine, 68. https://doi.org/10.1016/j.ebiom.2021.103412 Cite
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Lab-on-a-Chip Based Mechanical Actuators and Sensors for Single-Cell and Organoid Culture Studies

The molecular networks that activate in cells in response to mechanical stimuli are yet not well-understood. Our limited knowledge stems partially from the lack of available tools that are capable of exerting controlled mechanical stress to individual cells and at the same time observing their responses at subcellular to molecular resolution.
[Journal of Applied Physics]
Männik, J., Teshima, T. F., Wolfrum, B., & Yang, D. (2021). Lab-on-a-chip based mechanical actuators and sensors for single-cell and organoid culture studies. Journal of Applied Physics, 129(21), 210905. https://doi.org/10.1063/5.0051875 Cite
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ZEISS Innovation Hub in Dresden Opens Its Doors

An official opening ceremony for the Hub will take place once it is permissible to do so. For the first Hub program – research into organoid models – Dr. Kai Wicker and his team have moved into the EKFZ for Digital Health on the campus of the Carl Gustav Carus University Hospital – a stone’s throw away from top experts in the field.
[Technische Universität Dresden (EurekAlert!)]
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Oncogenic BRAF, Unrestrained by TGFβ-Receptor Signaling, Drives Right-Sided Colonic Tumorigenesis

The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.
[Nature Communications]
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Organoids and Organs-on-Chips: Insights into Human Gut-Microbe Interactions

The authors review recent advances in the co-culture of microbes with intestinal and colonic epithelia, comparing the rapidly developing fields of organoids and organs-on-chips with other standard models.
[Cell Host & Microbe]
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