Reaching into the Toolbox: Stem Cell Models to Study Neuropsychiatric Disorders

Investigators discussed available tools, including CRISPR-Cas9, and the applications of these tools to develop cell-based 2D models and 3D brain organoid models that better represent and unravel the intricacies of neuropsychiatric disorder pathophysiology.
[Stem Cell Reports]
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Biomimetic Human Lung-on-a-Chip with Colorful Displaying Microphysiological Breath

Scientists presented a novel biomimetic 3D microphysiological lung-on-a-chip system with breathing visuality.
[Advanced Materials]
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Interactions with Stromal Cells Promote a More Oxidized Cancer Cell Redox State in Pancreatic Tumors

Nontransformed cells in tumors can help cancer cells overcome metabolic limitations, particularly in pancreatic cancer, where pancreatic stellate cells (PSCs) promote cancer cell proliferation and tumor growth.
[Science Advances]
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Grants Will Be Used to Explore 3 Pioneering Treatments

The Michael J. Fox Foundation has awarded three new grants totaling $5.2 million to Arizona State University to explore three pioneering treatments for Parkinson’s disease.
[Arizona State University]
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Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids

The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.
[Nature Communications]
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Androgens Increase Excitatory Neurogenic Potential in Human Brain Organoids

Investigators used brain organoids to show that although sex chromosomal complement had no observable effect on neurogenesis, sex steroids—namely androgens—led to increased proliferation of cortical progenitors and an increased neurogenic pool.
[Nature]
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Anti-miR-135/SPOCK1 Axis Antagonizes the Influence of Metabolism on Drug Response in Intestinal/Colon Tumor Organoids

The authors analyzed the expression of 373 miRNAs and 12 deregulated metabolic genes in murine duodenal polyps and non-polyp-derived organoids.
[Oncogenesis]
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An In Vitro Chronic Damage Model Impairs Inflammatory and Regenerative Responses in Human Colonoid Monolayers

Investigators developed a chronic-injury model in human colonoid monolayers by repeated rounds of air-liquid interface and submerged culture.
[Cell Reports]
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Ex Vivo and In Vivo Suppression of SARS-CoV-2 with Combinatorial AAV-RNAi Expression Vectors

Researchers comprehensively illustrated the capacity of adeno-associated virus (AAV) vectors co-expressing a cocktail of three short hairpin RNAs directed against the SARS-CoV-2 RdRp and N genes as versatile and effective antivirals.
[Molecular Therapy]
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GSDMB Is Increased in IBD and Regulates Epithelial Restitution/Repair Independent of Pyroptosis

The authors reported increased gasdermin B (GSDMB) in inflammatory bowel disease, with single-cell analysis identifying epithelial specificity to inflamed colonocytes/crypt top colonocytes.
[Cell]
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Development of Human Alveolar Epithelial Cell Models to Study Distal Lung Biology and Disease

Researchers used de-identified human remnant transplant lungs to develop a method to establish alveolar epithelial cell lines. The lines grew well in 2D culture as epithelial monolayers expressing lung progenitor markers.
[iScience]
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