FBXW11 Contributes to Stem-Cell-Like Features and Liver Metastasis through Regulating HIC1-Mediated SIRT1 Transcription in Colorectal Cancer

The authors explored the role of F-box and WD repeat domain containing 11 (FBXW11) in the development and metastasis of colorectal cancer (CRC). FBXW11 was overexpressed in colorectal tumor tissues and its overexpression was associated with a poor prognosis of CRC patients.
[Cell Death & Disease]
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Label-Free Cancer Stem-Like Cell Assay Conducted at a Single Cell Level Using Microfluidic Mechanotyping Devices

Researchers investigated the mechanical phenotype of the human colon adenocarcinoma cell, HT29, which is known to be a heterogeneous cell line with both multipotency and self-renewal abilities.
[Analytical Chemistry]
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Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids

Investigators explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity.
[Physiological Genomics]
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A Functional Genetic Toolbox for Human Tissue-Derived Organoids

Using a human fetal lung organoid system as an example the authors systematically developed and optimized a complete genetic toolbox for use in tissue-derived organoids.
[eLife]
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MYC Hyperactivates WNT Signaling in APC/CTNNB1-Mutated Colorectal Cancer Cells through miR-92a-Dependent Repression of DKK3

Researchers examined the role of DKK3 by overexpression and knockdown and discovered that DKK3 suppressed Wnt signaling in APC-null murine colonic organoids and human colon cancer cells despite the presence of downstream activating mutations in the Wnt pathway.
[Molecular Cancer Research]
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Application of CRISPR-Cas9 Based Gene Editing to Study the Pathogenesis of Colon and Liver Cancer Using Organoids

Genetically modified organoids have been developed by sequential knockout and knockin of driver mutations by genome editing followed by niche-based selection.
[Hepatology International]
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Building Better Lab Models of Human Tumors

Prostate cancer researcher Dr. John Lee garnered a National Institutes of Health New Innovator Award to fund his breakthrough approach that promises to help make scientific tumor models better capture the complex biology of tumors that arise naturally.
[Fred Hutchinson Cancer Research Center]
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Magee-Womens Research Institute Announces Finalists for $1 Million Prize

Magee-Womens Research Institute will award the $1 million Magee Prize to an international team of scientists during the Magee-Womens Summit Nov. 16 to 18. The prize will help fund new research initiatives and transdisciplinary collaborations to promote knowledge and enhance the health and wellness of women and infants worldwide.
[University of Pittsburgh Schools of the Health Sciences]
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Establishment and Drug Screening of Patient-Derived Extrahepatic Biliary Tract Carcinoma Organoids

Researchers successfully established five gallbladder carcinoma and one extrahepatic cholangiocarcinoma patient-derived organoids (PDOs). Histological staining was used to compare structural features between the original tissues and cancer PDOs.
[Cancer Cell International]
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RING-Finger Protein 6 Promotes Colorectal Tumorigenesis by Transcriptionally Activating SF3B2

To understand whether transcriptional activity of RING-finger protein 6 (RNF6) underlied its oncogenic effect, the authors performed integrated chromatin immunoprecipitation-sequencing and RNA-sequencing analysis to identify splicing factor 3b subunit 2 (SF3B2) as a potential downstream target of RNF6.
[Oncogene]
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Preclinical Tumor Organoid Models in Personalized Cancer Therapy: Not Everyone Fits the Mold

Scientists discuss the patient-derived organoids as a native tumor microenvironment mimicking model in personalized cancer therapy.
[Experimental Cell Research]
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