Researchers investigated the transcriptomes of jejunum organoids derived from the same pig as well as batch-to-batch variation of organoids derived from different pigs over long-term passage.
[Frontiers in Cell and Developmental Biology]
6445218 MZZEPKL7 items 1 apa default asc 1
Investigators tested conditioned media of individual patient-derived organoids (PDOs) for cell-free tumor DNA to detect driver mutations already early on during the expansion process in order to accelerate the genetic characterization of PDOs as well as subsequent functional testing.
6445218 KU2CGBFW items 1 apa default asc 1
Dantes, Z., Yen, H.-Y., Pfarr, N., Winter, C., Steiger, K., Muckenhuber, A., Hennig, A., Lange, S., Engleitner, T., Öllinger, R., Maresch, R., Orben, F., Heid, I., Kaissis, G. A., Shi, K., Topping, G. J., Stögbauer, F., Wirth, M., Peschke, K., … Reichert, M. (2020). Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology. JCI Insight. https://doi.org/10.1172/jci.insight.137809 Cite
In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2, as demonstrated by confocal and electron microscopy.
6445218 4JQ9TPTR items 1 apa default asc 1
Lamers, M. M., Beumer, J., Vaart, J. van der, Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Schayck, J. P. van, Mykytyn, A. Z., Duimel, H. Q., Donselaar, E. van, Riesebosch, S., Kuijpers, H. J. H., Schipper, D., Wetering, W. J. van de, Graaf, M. de, Koopmans, M., Cuppen, E., Peters, P. J., … Clevers, H. (2020). SARS-CoV-2 productively infects human gut enterocytes. Science, 369(6499), 50–54. https://doi.org/10.1126/science.abc1669 Cite
Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
Researchers showed that CDK5 regulatory subunit-associated protein 3 was weakly expressed in gastric cancer stem-like cells (CSCs) and was negatively correlated with the gastric CSC marker CD44.
[British Journal of Cancer]
1254621 ZC8V5S75 items 1 apa default asc 1
Investigators used human colonoids comprising goblet cells and a thick mucin barrier as an intestinal model to investigate Pic’s roles during infection with EAEC.
6445212 LAP25SVM items 1 apa default asc 1
On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
Investigators described mammary organoids with a basal‐in phenotype where the basement membrane was located on the interior surface of the organoid.
[Advanced Healthcare Materials]
6606345 8FDNPYXW items 1 apa default asc 1
A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.