Congruence of Transcription Programs in Adult Stem Cell-Derived Jejunum Organoids and Original Tissue during Long-Term Culture

Researchers investigated the transcriptomes of jejunum organoids derived from the same pig as well as batch-to-batch variation of organoids derived from different pigs over long-term passage.
[Frontiers in Cell and Developmental Biology]
van der Hee, B., Madsen, O., Vervoort, J., Smidt, H., & Wells, J. M. (2020). Congruence of Transcription Programs in Adult Stem Cell-Derived Jejunum Organoids and Original Tissue During Long-Term Culture. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.00375 Cite
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Implementing Cell-Free DNA of Pancreatic Cancer Patient-Derived Organoids for Personalized Oncology

Investigators tested conditioned media of individual patient-derived organoids (PDOs) for cell-free tumor DNA to detect driver mutations already early on during the expansion process in order to accelerate the genetic characterization of PDOs as well as subsequent functional testing.
[JCI Insight]
Dantes, Z., Yen, H.-Y., Pfarr, N., Winter, C., Steiger, K., Muckenhuber, A., Hennig, A., Lange, S., Engleitner, T., Öllinger, R., Maresch, R., Orben, F., Heid, I., Kaissis, G. A., Shi, K., Topping, G. J., Stögbauer, F., Wirth, M., Peschke, K., … Reichert, M. (2020). Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology. JCI Insight. https://doi.org/10.1172/jci.insight.137809 Cite
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SARS-CoV-2 Productively Infects Human Gut Enterocytes

In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2, as demonstrated by confocal and electron microscopy.
[Science]
Lamers, M. M., Beumer, J., Vaart, J. van der, Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Schayck, J. P. van, Mykytyn, A. Z., Duimel, H. Q., Donselaar, E. van, Riesebosch, S., Kuijpers, H. J. H., Schipper, D., Wetering, W. J. van de, Graaf, M. de, Koopmans, M., Cuppen, E., Peters, P. J., … Clevers, H. (2020). SARS-CoV-2 productively infects human gut enterocytes. Science, 369(6499), 50–54. https://doi.org/10.1126/science.abc1669 Cite
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Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]
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United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider]
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Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]
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CDK5RAP3 as Tumor Suppressor Negatively Regulates Self-Renewal and Invasion and Is Regulated by ERK1/2 Signaling in Human Gastric Cancer

Researchers showed that CDK5 regulatory subunit-associated protein 3 was weakly expressed in gastric cancer stem-like cells (CSCs) and was negatively correlated with the gastric CSC marker CD44.
[British Journal of Cancer]
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Mucus Layer Modeling of Human Colonoids during Infection with Enteroaggragative E. coli

Investigators used human colonoids comprising goblet cells and a thick mucin barrier as an intestinal model to investigate Pic’s roles during infection with EAEC.
[Scientific Reports]
Liu, L., Saitz-Rojas, W., Smith, R., Gonyar, L., In, J. G., Kovbasnjuk, O., … Ruiz-Perez, F. (2020). Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli. Scientific Reports, 10(1), 10533. https://doi.org/10.1038/s41598-020-67104-4 Cite
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NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]
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Cancer Cell Invasion of Mammary Organoids with Basal‐In Phenotype

Investigators described mammary organoids with a basal‐in phenotype where the basement membrane was located on the interior surface of the organoid.
[Advanced Healthcare Materials]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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