To overcome limitations and address species-specific cellular organization, investigators derived organoids from rapidly developing teleosts.
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The authors review the current achievements in brain organoid biology and their relevance to HIV infection of the brain (neuroHIV) research efforts.
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Investigators developed a patient-derived colorectal cancer organoid model and performed pairwise analysis of 87 CCOs and their matched primary tumors. The tumor immune microenvironment type of the primary tumor was classified as immuno-active, immuno-exhausted, or immuno-desert.
[Journal of Experimental & Clinical Cancer Research]
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Cho, E. J., Kim, M., Jo, D., Kim, J., Oh, J.-H., Chung, H. C., Lee, S., Kim, D., Chun, S.-M., Kim, J., Lee, H., Kim, T. W., Yu, C. S., Sung, C. O., & Jang, S. J. (2021). Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survival. Journal of Experimental & Clinical Cancer Research, 40(1), 230. https://doi.org/10.1186/s13046-021-02034-1 Cite
The authors identified a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 and environmental exposure to an organophosphate pesticide an iPSC-derived human 3D brain model.
[Experimental Health Perspectives]
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Modafferi, S., Zhong, X., Kleensang, A., Murata, Y., Fagiani, F., Pamies, D., Hogberg, H. T., Calabrese, V., Lachman, H., Hartung, T., & Smirnova, L. (n.d.). Gene–Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres. Environmental Health Perspectives, 129(7), 077001. https://doi.org/10.1289/EHP8580 Cite
Recently, synthetic polymeric hydrogels, with high biocompatibility and biodegradability, stability, uniformity of compositions, and high throughput properties, have emerged as potential materials for achieving 3D architectures for organoid cultures.
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Ma, P., Chen, Y., Lai, X., Zheng, J., Ye, E., Loh, X. J., Zhao, Y., Parikh, B. H., Su, X., You, M., Wu, Y.-L., & Li, Z. (n.d.). The Translational Application of Hydrogel for Organoid Technology: Challenges and Future Perspectives. Macromolecular Bioscience, n/a(n/a), 2100191. https://doi.org/10.1002/mabi.202100191 Cite
The authors review the major developments in ovarian cancer, including genetics, model systems and technologies available for their study and the implications of applying epigenetic therapies to ovarian cancer.
[International Journal of Cancer]
Vyant Bio, Inc. announced that its wholly-owned subsidiary, StemoniX, Inc. was issued US Patent No. 11054408, titled “High Throughput Optical Assay of Human Mixed Cell Population Spheroids” by the United States Patent and Trademark Office.
[Vyant Bio, Inc.]
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In murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) resulted in ATM-mediated phosphorylation and activation of the YAP1 transcriptional coactivator, which in turn up-regulated pro-IL-18, a pivotal immune regulator in inflammatory bowel disease pathogenesis.
[Proceedings of the National Academy of Sciences of the United States of America]
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Scientists reported that cells derived from claudin-low mammary tumors, a mesenchymal subtype of triple-negative breast cancer, exhibited a distinctive organoid structure with extended “spikes” in 3D matrices.
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Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 infection points. Scientists showed that pericyte-like cells, when integrated into a cortical organoid, were capable of infection with authentic SARS-CoV-2.
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Cholangiocytes were collected from intrahepatic bile ducts, gallbladder, and crypts from the small intestine using gravity settling and multi-step centrifugation methods, and embedded in Matrigel to grow into 3D spheroids in suitable culture medium.
[Military Medical Research]
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