Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment

Investigators evaluated the difference between controls’ and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients’ derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.
[Movement Disorders]
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A Mix of Functional Amino Acids and Grape Polyphenols Promotes the Growth of Piglets, Modulates the Gut Microbiota In Vivo and Regulates Epithelial Homeostasis in Intestinal Organoids

Experiments in piglet jejunum organoids revealed that the mix of amino acids and polyphenols upregulated the gene expression of epithelial differentiation markers while it reduced the gene expression of proliferation and innate immunity markers.
[Amino Acids]
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Single-Cell Atlas of Lineage States, Tumor Microenvironment and Subtype-Specific Expression Programs in Gastric Cancer

The authors observed increased plasma cell proportions in diffuse-type tumors associated with epithelial-resident KLF2, and stage-wise accrual of cancer-associated fibroblast sub-populations marked by high INHBA and FAP co-expression.
[Cancer Discovery]
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Effects of Early Geometric Confinement on the Transcriptomic Profile of Human Cerebral Organoids

Scientists investigated the effects of early geometric confinements on transcriptomic changes during human cerebral organoids differentiation.
[BMC Biotechnology]
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Carbon Nanotubes Promote the Development of Intestinal Organoids through Regulating Extracellular Matrix Viscoelasticity and Intracellular Energy Metabolism

The authors investigated the profitable effect of carbon nanotubes (CNTs) with a different graphene layer and surface modification on the 3D model of intestinal organoids and demonstrated that CNTs promoted the development of intestinal organoids over time.
[ACS Nano]
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A Modified Nucleoside 6-thio-2′-deoxyguanosine Exhibits Anti-tumor Activity in Gliomas

Four patient-derived xenografts, two patient-derived organoi and two xenografts of human glioma cell lines were used to further investigate the therapeutic efficacy of 6-thio-2′-deoxyguanosine.
[Clinical Cancer Research]
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Organoid Models for Infectious Disease

Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions.
[Annual Review of Medicine]
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Intestinal Organoids in Co-Culture: Redefining the Boundaries of Gut Mucosa Ex Vivo Modeling

Organoid-derived intestinal co-culture models have established themselves as convenient tools to re-enact such pathophysiological events, explore interactions between selected cell populations and assess their roles with a central focus on intestinal barrier recovery and stabilization.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
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FBXW11 Contributes to Stem-Cell-Like Features and Liver Metastasis through Regulating HIC1-Mediated SIRT1 Transcription in Colorectal Cancer

The authors explored the role of F-box and WD repeat domain containing 11 (FBXW11) in the development and metastasis of colorectal cancer (CRC). FBXW11 was overexpressed in colorectal tumor tissues and its overexpression was associated with a poor prognosis of CRC patients.
[Cell Death & Disease]
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Label-Free Cancer Stem-Like Cell Assay Conducted at a Single Cell Level Using Microfluidic Mechanotyping Devices

Researchers investigated the mechanical phenotype of the human colon adenocarcinoma cell, HT29, which is known to be a heterogeneous cell line with both multipotency and self-renewal abilities.
[Analytical Chemistry]
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Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids

Investigators explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity.
[Physiological Genomics]
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