Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids

Scientists transplanted human embryonic stem cell-derived cerebral organoids at six or ten weeks after differentiation into mouse cerebral cortices.
[Stem Cell Reports]
Kitahara, T., Sakaguchi, H., Morizane, A., Kikuchi, T., Miyamoto, S., & Takahashi, J. (2020). Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2020.06.016 Cite
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Modeling Neoplastic Disease with Spheroids and Organoids

The authors summarize the recent advances in the use of 3D systems for cancer modeling, focusing on their innovative translational applications, looking at future challenges, and comparing them with most widely used animal models.
[Journal of Hematology & Oncology]
Modeling neoplastic disease with spheroids and organoids | Journal of Hematology & Oncology | Full Text. (n.d.). Retrieved July 22, 2020, from https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00931-0 Cite
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Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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CalciMedica and EpiPharma Enter into Research Collaboration to Discover and Develop CRAC Channel Inhibitor Therapies

CalciMedica and EpiPharma announced that they have entered into a collaboration agreement to use EpiPharma’s state-of-the-art pre-Clinical Drug Testing and Diagnostics Laboratory Platform to accelerate the discovery and development of CalciMedica’s CRAC channel inhibitor novel drug pipeline.
[CalciMedica]
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Basal-Like and Classical Cells Coexist in Pancreatic Cancer Revealed by Single-Cell Analysis on Biopsy-Derived Pancreatic Cancer Organoids from the Classical Subtype

The authors performed single‐cell transcriptomic analyses using combinational barcoding exclusively on epithelial cells from six different classical pancreatic ductal adenocarcinoma patients obtained by Endoscopic Ultrasound with Fine Needle Aspiration.
[FASEB Journal]
Juiz, N., Elkaoutari, A., Bigonnet, M., Gayet, O., Roques, J., Nicolle, R., Iovanna, J., & Dusetti, N. (n.d.). Basal-like and classical cells coexist in pancreatic cancer revealed by single-cell analysis on biopsy-derived pancreatic cancer organoids from the classical subtype. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202000363RR Cite
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The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News]
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Bile Acids Regulate Intestinal Antigen Presentation and Reduce Graft-Versus-Host Disease without Impairing the Graft-Versus-Leukemia Effect

Scientists observed that application of bile acids decreased cytokine-induced cell death in intestinal organoids and cell lines.
[Haematologica]
Haring, E., Uhl, F. M., Andrieux, G., Proietti, M., Bulashevska, A., Sauer, B., Braun, L. M., Gomez, E. de V., Esser, P. R., Martin, S. F., Pfeifer, D., Follo, M., Schmitt-Graeff, A., Buescher, J., Duyster, J., Grimbacher, B., Boerries, M., Pearce, E. L., Zeiser, R., & Apostolova, P. (2020). Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica. https://doi.org/10.3324/haematol.2019.242990 Cite
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Regulated IFN Signalling Preserves the Stemness of Intestinal Stem Cells by Restricting Differentiation Into Secretory-Cell Lineages

Scientists describe a transcriptional regulator that preserves the stemness of intestinal stem cells by restricting their differentiation into secretory-cell lineages.
[Nature Cell Biology]
Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R., & Ohteki, T. (2020). Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nature Cell Biology, 1–8. https://doi.org/10.1038/s41556-020-0545-5 Cite
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EU Leaders Slash Science Spending in €1.8 Trillion Deal

Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[Science Insider]
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‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider]
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Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints

Amid concerns that the torrent of research papers on COVID-19 could be leading to an excess of sloppy work, a computer scientist who develops automated programs to spot duplicate images in research papers is running his software across the world’s coronavirus preprints. So far, his efforts have yielded mixed success and some controversy.
[Nature News]
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Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

Neuregulin 1 robustly stimulated proliferation in crypts and induced budding in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase and AKT.
[Cell Stem Cell]
Jardé, T., Chan, W. H., Rossello, F. J., Kaur Kahlon, T., Theocharous, M., Kurian Arackal, T., Flores, T., Giraud, M., Richards, E., Chan, E., Kerr, G., Engel, R. M., Prasko, M., Donoghue, J. F., Abe, S., Phesse, T. J., Nefzger, C. M., McMurrick, P. J., Powell, D. R., … Abud, H. E. (2020). Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium. Cell Stem Cell. https://doi.org/10.1016/j.stem.2020.06.021 Cite
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