Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Tumor Promoting Effect of Spheroids in an Orthotopic Prostate Cancer Mouse Model

April 17, 2024

[Scientific Reports] Investigators established a technique for intraprostatic implantation of prostate cancer (PCa) spheroids and to identify the impact of three-dimensional organization of PCa cells on tumor progression and metastasis in a representative in vivo model.

Overexpression of TNFSF11 Reduces GPX4 Levels and Increases Sensitivity to Ferroptosis Inducers in Lung Adenocarcinoma

April 16, 2024

[Journal of Translational Medicine] Scientists employed the tumor immune estimation resource database to scrutinize tumor necrosis factor superfamily 11 (TNFSF11) expression across various cancer types.

SARS-CoV-2 Infection Activates Inflammatory Macrophages in Vascular Immune Organoids

April 16, 2024

[Scientific Reports] The authors established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection.

High-Dose Short-Term Osimertinib Treatment Is Effective in Patient-Derived Metastatic Colorectal Cancer Organoids

April 11, 2024

[BJC Reports] Researchers investigated the cytotoxic anti-tumor effect of high-dose, short-term tyrosine kinase inhibitor treatment on five patient-derived tumor organoids.

Blood Vessel Organoids Generated by Base Editing and Harboring Single Nucleotide Variation in Notch3 Effectively Recapitulate CADASIL-Related Pathogenesis

April 11, 2024

[Molecular Neurobiology] The authors focused on in vitro modeling and therapeutic target finding of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary stroke disorder caused by mutations in the NOTCH3 gene.

Survival and Functional Integration of Human Embryonic Stem Cell–Derived Retinal Organoids after Shipping and Transplantation into Retinal Degeneration Rats

April 11, 2024

[Stem Cells And Development] Because derivation of retinal organoids and transplantation are frequently split between geographically distant locations, scientists veloped a special shipping device and protocol capable of the organoids' delivery to any location.

Neonatal Enteroids Absorb Extracellular Vesicles from Human Milk-Fed Infant Digestive Fluid

April 11, 2024

[Journal of Extracellular Vesicles] Researchers developed an extracellular vesicle isolation pipeline from small volumes of human milk and neonatal intestinal contents after milk feeding to address the hypothesis that human milk contains extracellular vesicles survive in vivo neonatal digestion to be taken up intestinal epithelial cells.

Promising Preclinical Models for Lung Cancer Research—Lung Cancer Organoids: A Narrative Review

April 11, 2024

[Translational Lung Cancer Research] The authors summarize the methodology, the problems, and the solutions in the lung cancer organoids generation, its application and limitations, as well as proposing future challenges and perspectives.

‘Mini Liver’ Will Grow in Person’s Own Lymph Node in Bold New Trial

April 11, 2024

[Nature] A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional ‘miniature liver’. The procedure, developed by the biotechnology firm LyGenesis, marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.

Neratinib Could Be Effective As Monotherapy or in Combination With Trastuzumab in HER2-Low Breast Cancer Cells and Organoid Models

April 11, 2024

[British Journal Of Cancer] The authors investigated the effect of trastuzumab monotherapy and its combination with different HER2 targeting treatments in a panel of breast cancer cell lines and patient-derived organoids using biochemical methods and cell viability assays.

Examination of Wnt Signaling as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma (PDAC) Using a Pancreatic Tumor Organoid Library (PTOL)

April 11, 2024

[PLOS One] Scientists constructed patient-derived organoids derived from pancreatic tumor organoid libraries. Each pancreatic organoid demonstrated varied niche factor dependencies, providing an avenue for targeted therapy, supported through growth analysis following combinatory treatment of Wnt inhibitor and standard chemotherapy in vitro.

Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons

April 10, 2024

[Nature Communications] To understand the mechanistic significance of inter-regional projections on development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.