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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
High-Dose Short-Term Osimertinib Treatment Is Effective in Patient-Derived Metastatic Colorectal Cancer Organoids
[BJC Reports] Researchers investigated the cytotoxic anti-tumor effect of high-dose, short-term tyrosine kinase inhibitor treatment on five patient-derived tumor organoids.
Blood Vessel Organoids Generated by Base Editing and Harboring Single Nucleotide Variation in Notch3 Effectively Recapitulate CADASIL-Related Pathogenesis
[Molecular Neurobiology] The authors focused on in vitro modeling and therapeutic target finding of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common form of hereditary stroke disorder caused by mutations in the NOTCH3 gene.
Survival and Functional Integration of Human Embryonic Stem Cell–Derived Retinal Organoids after Shipping and Transplantation into Retinal Degeneration Rats
[Stem Cells And Development] Because derivation of retinal organoids and transplantation are frequently split between geographically distant locations, scientists veloped a special shipping device and protocol capable of the organoids' delivery to any location.
Neonatal Enteroids Absorb Extracellular Vesicles from Human Milk-Fed Infant Digestive Fluid
[Journal of Extracellular Vesicles] Researchers developed an extracellular vesicle isolation pipeline from small volumes of human milk and neonatal intestinal contents after milk feeding to address the hypothesis that human milk contains extracellular vesicles survive in vivo neonatal digestion to be taken up intestinal epithelial cells.
Promising Preclinical Models for Lung Cancer Research—Lung Cancer Organoids: A Narrative Review
[Translational Lung Cancer Research] The authors summarize the methodology, the problems, and the solutions in the lung cancer organoids generation, its application and limitations, as well as proposing future challenges and perspectives.
‘Mini Liver’ Will Grow in Person’s Own Lymph Node in Bold New Trial
[Nature] A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional ‘miniature liver’. The procedure, developed by the biotechnology firm LyGenesis, marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.
Neratinib Could Be Effective As Monotherapy or in Combination With Trastuzumab in HER2-Low Breast Cancer Cells and Organoid Models
[British Journal Of Cancer] The authors investigated the effect of trastuzumab monotherapy and its combination with different HER2 targeting treatments in a panel of breast cancer cell lines and patient-derived organoids using biochemical methods and cell viability assays.
Examination of Wnt Signaling as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma (PDAC) Using a Pancreatic Tumor Organoid Library (PTOL)
[PLOS One] Scientists constructed patient-derived organoids derived from pancreatic tumor organoid libraries. Each pancreatic organoid demonstrated varied niche factor dependencies, providing an avenue for targeted therapy, supported through growth analysis following combinatory treatment of Wnt inhibitor and standard chemotherapy in vitro.
Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons
[Nature Communications] To understand the mechanistic significance of inter-regional projections on development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.
Genetics of Cystogenesis in Base-Edited Human Organoids Reveal Therapeutic Strategies for Polycystic Kidney Disease
[Cell Stem Cell] Researchers established hPSCs in allelic series representing four common nonsense mutations, using CRISPR base editing.
KCNJ2 Inhibition Mitigates Mechanical Injury in a Human Brain Organoid Model of Traumatic Brain Injury
[Cell Stem Cell] Scientists developed a high-intensity ultrasound platform to inflict mechanical injury to iPSC-derived cortical organoids.
Identification of Qualitative Characteristics of Immunosuppression in Sepsis Based on Immune-Related Genes and Immune Infiltration Features
[Heliyon] Scientists analyzed whole blood data obtained from patients with sepsis and control samples sourced from three datasets. Commonly dysregulated immune-related genes among these three datasets were identified.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
