Multiple Low Dose Therapy as an Effective Strategy to Treat EGFR Inhibitor-Resistant NSCLC Tumors

The authors showed that as little as 20% of the individual effective drug doses was sufficient to completely block MAPK signaling and proliferation when used in 3D or 4D inhibitor combinations.
[Nature Communications]
Fernandes Neto, J. M., Nadal, E., Bosdriesz, E., Ooft, S. N., Farre, L., McLean, C., Klarenbeek, S., Jurgens, A., Hagen, H., Wang, L., Felip, E., Martinez-Marti, A., Vidal, A., Voest, E., Wessels, L. F. A., van Tellingen, O., Villanueva, A., & Bernards, R. (2020). Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours. Nature Communications, 11(1), 3157. https://doi.org/10.1038/s41467-020-16952-9 Cite
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Glucagon like Peptide-2 for Intestinal Stem Cell and Paneth Cell Repair during Graft-Versus-Host Disease in Mice and Humans

Investigators found that L-cells were a target of acute graft-versus-host disease (GVHD) and that glucagon-like-peptide-2-based treatment of acute GVHD restored intestinal homeostasis via an increase of intestinal stem cells and paneth cells without impairing graft-versus-leukemia effects.
[Blood]
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Lineage Reversion Drives WNT Independence in Intestinal Cancer

Scientists showed that while WNT suppression blocked tumor growth in most organoid and in vivo colorectal cancer (CRC) models, the accumulation of CRC-associated genetic alterations enabled drug resistance and WNT-independent growth.
[Cancer Discovery]
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Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction

Scientists employed a multicellular 3D neurovascular unit organoid containing human brain microvascular endothelial cells, pericytes, astrocytes, microglia, oligodendrocytes and neurons to model the effects of hypoxia and neuroinflammation on blood-brain barrier function.
[Scientific Reports]
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Organoid Models for Mammary Gland Dynamics and Breast Cancer

The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast.
[Current Opinion in Cell Biology]
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The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis

Investigators report that periodontal inflammation exacerbates gut inflammation in vivo. Periodontitis led to expansion of oral pathobionts, including Klebsiella and Enterobacter species, in the oral cavity.
[Cell]
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis: Cell. (n.d.). Retrieved June 17, 2020, from https://www.cell.com/cell/fulltext/S0092-8674(20)30681-4 Cite
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Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development

Scientists used single-cell RNA sequencing to interrogate the rare CD34+ progenitor and the more differentiated CD34 fractions in the human postnatal thymus.
[Immunity]
Le, J., Park, J. E., Ha, V. L., Luong, A., Branciamore, S., Rodin, A. S., Gogoshin, G., Li, F., Loh, Y.-H. E., Camacho, V., Patel, S. B., Welner, R. S., & Parekh, C. (2020). Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development. Immunity, 52(6), 1105-1118.e9. https://doi.org/10.1016/j.immuni.2020.05.010 Cite
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Guanylate-Binding Proteins Convert Cytosolic Bacteria Into Caspase-4 Signaling Platforms

The authors showed that in interferon-γ-stimulated cells guanylate-binding proteins assemble on the surface of Gram-negative bacteria into polyvalent signaling platforms required for activation of caspase-4.
[Nature Immunology]
Wandel, M. P., Kim, B.-H., Park, E.-S., Boyle, K. B., Nayak, K., Lagrange, B., Herod, A., Henry, T., Zilbauer, M., Rohde, J., MacMicking, J. D., & Randow, F. (2020). Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0697-2 Cite
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The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells from Their Niche and Differentiation into Enterocyte vs Secretory Lineages

Scientists analyzed Notch regulation by examining expression profiles of small intestinal organoids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the γ-secretase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.
[Gastroenterology]
Baulies, A., Angelis, N., Foglizzo, V., Danielsen, E. T., Patel, H., Novellasdemunt, L., Kucharska, A., Carvalho, J., Nye, E., Coppi, P. D., & Li, V. S. W. (2020). The Transcription co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation into Enterocyte vs Secretory Lineages. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.06.012 Cite
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Enteroendocrine Dynamics – New Tools Reveal Hormonal Plasticity in the Gut

Researchers analyzed advantages and disadvantages of novel in vitro tools, adult stem cell or iPS-derived intestinal organoids, that have been crucial for recent findings on enteroendocrine development and plasticity.
[Endocrine Reviews]
Beumer, J., Gehart, H., & Clevers, H. (n.d.). Enteroendocrine dynamics – New tools reveal hormonal plasticity in the gut. Endocrine Reviews. https://doi.org/10.1210/endrev/bnaa018 Cite
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