Keep Current with the Latest in Cell Biology Research

Generation of Knockout Rabbits with X-Linked Severe Combined Immunodeficiency (X-SCID) Using CRISPR/Cas9

X-SCID rabbits presented immunodeficient phenotypes including the loss of T and B cells and hypoplasia of the thymus.
[Scientific Reports]
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The Contribution from Interleukin-27 towards Rheumatoid Inflammation: Insights from Gene Expression

The authors assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity]
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PD-L1 Expression by Dendritic Cells Is a Key Regulator of T-Cell Immunity in Cancer

Investigators demonstrated that dendritic cells represented a critical source of PD-L1, despite being vastly outnumbered by PD-L1+ macrophages.
[Nature Cancer]
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Tet2 and Tet3 in B Cells Are Required to Repress CD86 and Prevent Autoimmunity

The authors report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice.
[Nature Immunology]
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Analysis of Ex Vivo Expanded and Activated Clinical-Grade Human NK Cells after Cryopreservation

Scientists evaluated activity of fresh and C/T EA NK cells generated by interleukin (IL)-15, IL-2 and CD137L expansion.
[CytoTherapy]
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Serum Adipokines/Related Inflammatory Factors and Ratios as Predictors of Infrapatellar Fat Pad Volume in Osteoarthritis: Applying Comprehensive Machine Learning Approaches

Scientists used machine learning approaches to predict serum levels of some adipokines/related inflammatory factors and their ratios on knee infrapatellar fat pad volume of osteoarthritis patients.
[Scientific Reports]
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Evidence for a Role of RUNX1 as Recombinase Cofactor for TCRβ Rearrangements and Pathological Deletions in ETV6-RUNX1 ALL

Scientists employed a RUNX1 knock-out mouse model and demonstrate by deep TCRβ sequencing, immunostaining and chromatin immunoprecipitation that RUNX1 binds to the initiation site of TCRβ rearrangement and its homozygous inactivation induced severe structural changes of the rearranged TCRβ gene, whereas heterozygous inactivation had almost no impact.
[Scientific Reports]
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Difference in Presence and Number of CD83+ Dendritic Cells in Patients with Ulcerative Colitis and Crohn’s Disease

There were 154 subjects included in this study: 60 with ulcerative colitis, 19 with Crohn’s disease and 75 in the control group. Colonic biopsy was performed in all subjects. Specimens were incubated with a primary anti-CD83 antibody.
[Scientific Reports]
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Meningeal Lymphatics Clear Erythrocytes That Arise from Subarachnoid Hemorrhage

Scientists showed that a markedly higher number of erythrocytes are accumulated in the lymphatics of cervical lymph nodes and meningeal lymphatics after subarchnoid hemorrhage.
[Nature Communications]
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Microbiota-Governed MicroRNA-204 Impairs Endothelial Function and Blood Pressure Decline during Inactivity in DB/DB Mice

Investigators report that microRNA-204 promoted endothelial dysfunction and impairment in blood pressure decline during inactivity.
[Scientific Reports]
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The Hippo Pathway Oncoprotein YAP Promotes Melanoma Cell Invasion and Spontaneous Metastasis

To analyze the Hippo pathway in cutaneous melanoma, researchers generated a transcriptional signature of melanoma cells that overexpressed YAP, the key downstream Hippo pathway oncoprotein.
[Oncogene]

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