Keep Current with the Latest in Cell Biology Research

Hypoxia-Preconditioned Placenta-Derived Mesenchymal Stem Cells Rescue Optic Nerve Axons via Differential Roles of Vascular Endothelial Growth Factor in an Optic Nerve Compression Animal Model

Scientists established a hypoxia-preconditioned strain using a hypoxic chamber. The human placenta–derived stem cells were exposed to short-term hypoxic conditions of 2.2% O2 and 5.5% CO2.
[Molecular Neurobiology]
Kwon, H., Park, M., Nepali, S., & Lew, H. (2020). Hypoxia-Preconditioned Placenta-Derived Mesenchymal Stem Cells Rescue Optic Nerve Axons Via Differential Roles of Vascular Endothelial Growth Factor in an Optic Nerve Compression Animal Model. Molecular Neurobiology. https://doi.org/10.1007/s12035-020-01965-8 Cite
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Plasma Membrane Vesicles of Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Acetaminophen-Induced Damage in HepG2 Cells: A Novel Stem Cell Therapy

PMVs from human umbilical cord (hUC) MSCs were prepared with an improved procedure including a chemical enucleation step followed by a mechanical extrusion. Plasma membrane vesicles of hUCMSCs were characterized and supplemented to hepatocyte cultures.
[Stem Cell Research & Therapy]
Lin, M., Li, S., Yang, L., Ye, D., Xu, L., Zhang, X., … Wei, C. (2020). Plasma membrane vesicles of human umbilical cord mesenchymal stem cells ameliorate acetaminophen-induced damage in HepG2 cells: a novel stem cell therapy. Stem Cell Research & Therapy, 11(1), 225. https://doi.org/10.1186/s13287-020-01738-z Cite
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Proteomic Profiling of Striatal Tissue of a Rat Model of Parkinson’s Disease after Implantation of Collagen-Encapsulated Human Umbilical Cord Mesenchymal Stem Cells

Human umbilical cord-MSCs were encapsulated into collagen hydrogels and implanted into the striatum of hemi‐parkinsonian male Sprague Dawley rats. One or 14 days after implantation, the area of interest was dissected using a cryostat.
[Journal of Tissue Engineering and Regenerative Medicine]
Santaella, A., Wessels, H. J. C. T., Kulkarni, P., Gloerich, J., Kuiperij, H. B., Bloem, B. R., … Verbeek, M. M. (n.d.). Proteomic profiling of striatal tissue of a rat model of Parkinson’s disease after implantation of collagen-encapsulated human umbilical cord mesenchymal stem cells. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/10.1002/term.3081 Cite
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Human Umbilical Cord Blood–Derived MSCs Exosome Attenuate Myocardial Injury by Inhibiting Ferroptosis in Acute Myocardial Infarction Mice

Compared with sham or normoxia groups, RT-PCR and western blotting showed that divalent metal transporter 1 expression was significantly increased, and Prussian blue staining, ferrous iro, MDA, and GSH level detection demonstrated that ferroptosis occurred in the infraction myocardium and in cardiomyocyte following hypoxia-induced injury.
[Cell Biology and Toxicology]
Song, Y., Wang, B., Zhu, X., Hu, J., Sun, J., Xuan, J., & Ge, Z. (2020). Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice. Cell Biology and Toxicology. https://doi.org/10.1007/s10565-020-09530-8 Cite
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Cross Talk between Mesenchymal and Glioblastoma Stem Cells: Communication beyond Controversies

The authors discuss recent findings on the complex nature of MSCs, focusing on their elusive impact on glioblastoma progression and aggressiveness by direct cell‐cell interaction and via secretome, also facing the perspectives and challenges in treatment strategies.
[Stem Cells Translational Medicine]
Bajetto, A., Thellung, S., Dellacasagrande, I., Pagano, A., Barbieri, F., & Florio, T. (n.d.). Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0161 Cite
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miR-410 Induces Both Epithelial-Mesenchymal Transition and Radioresistance through Activation of the PI3K/mTOR Pathway in Non-Small Cell Lung Cancer

Scientists demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays, and the miR-410-induced epithelial–mesenchymal transition and radioresistance were reversed by PI3K, Akt, and mTOR inhibitors or by restoring the expression of PTEN in non-small cell lung cancer cells.
[Signal Transduction and Targeted Therapy]
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Antisense Oligonucleotide-Mediated Correction of CFTR Splicing Improves Chloride Secretion in Cystic Fibrosis Patient-Derived Bronchial Epithelial Cells

Researchers tested an antisense oligonucleotide targeting the cystic fibrosis (CF) transmembrane conductance regulator c.3718-2477C>T mutation and showed that it effectively blocks aberrant splicing in primary bronchial epithelial cells from CF patients with the mutation.
[Nucleic Acids Research]

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High-Capacity Poly(2-oxazoline) Formulation of TLR 7/8 Agonist Extends Survival in a Chemo-Insensitive, Metastatic Model of Lung Adenocarcinoma

Researchers showed that their unique poly(2-oxazoline)–based nanomicellar formulation of Resiquimod, an imidazoquinoline Toll-like receptor 7/8 agonist, had a superior tumor inhibitory effect in a metastatic model of lung adenocarcinoma, relative to anti–PD-1 therapy or platinum-based chemotherapy.
[Science Advances]
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Creatv Announces Ability to Predict Immunotherapy Treatment Response for Non-Small Cell Lung Cancer Using a Simple Blood Test

Creatv Microtech has pioneered a blood test to predict treatment response in patients with stage II-III NSCLC treated with chemoradiation therapy and consolidated immunotherapy.
[Business Wire, Inc.]
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Latexin Deficiency in Mice Up-Regulates Inflammation and Aggravates Colitis through hECTD1/Rps3/Nf-κB Pathway

Ectopic expression of Latexin led to IκBα accumulation in intestinal epithelial cells, however, latexin knockdown enhanced the interaction of HECTD1 and Rps3, contributing to the ubiquitination degradation of IκBα, and subsequently enhanced inflammatory response.
[Scientific Reports]
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