Keep Current with the Latest in Cell Biology Research

Irradiation Dependent Inflammatory Response May Enhance Satellite Cell Engraftment

Scientists found no difference in the percentage of dying cells in immunodeficient dystrophic mouse muscles at the times after the irradiation dose that enhanced donor cell engraftment.
[Scientific Reports]
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A Reference Single-Cell Transcriptomic Atlas of Human Skeletal Muscle Tissue Reveals Bifurcated Muscle Stem Cell Populations

Differential expression analysis identified transcriptional profiles altered in the activated muscle stem/progenitor cells including genes associated with aging, obesity, diabetes, and impaired muscle regeneration, as well as long non-coding RNAs previously undescribed in human myogenic cells.
[Skeletal Muscle]
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Cytokine Regulation of Apoptosis-Induced Apoptosis and Apoptosis-Induced Cell Proliferation in Vascular Smooth Muscle Cells

Vascular smooth muscle cells (VSMCs) undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 and granulocyte-macrophage colony stimulating factor, leading to their secretion.
[Apoptosis]
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Exercise Adaptations: Molecular Mechanisms and Potential Targets for Therapeutic Benefit

The authors provide an overview of the beneficial adaptive responses to exercise and details the molecular mechanisms involved. The possibility of designing therapeutic interventions based on these molecular mechanisms is addressed, using relevant examples that have exploited this approach.
[Nature Reviews Endocrinology]
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Sarepta Therapeutics Signs Agreement with Hansa Biopharma for Imlifidase

Sarepta Therapeutics, Inc. announced an agreement with Hansa Biopharma, the leader in immunomodulatory enzyme technology for rare Immunoglobulin G mediated diseases, for imlifidase.
[Sarepta Therapeutics]
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Cytotoxic and Genotoxic Effects on Human Keratinocytes Triggered by Sphingomyelinase D from Loxosceles Venom

Loxosceles laeta venom, as well as sphingomyelinase D, increased intracellular superoxide levels, leading to DNA damage in human keratinocytes.
[Archives of Toxicology]
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A Novel Mechanism in Wound Healing: Laminin 332 Drives MMP9/14 Activity by Recruiting Syndecan-1 and CD44

By directly recruiting both syndecan-1 and CD44, laminin-332 G45 domain played a major role in regulating mechanisms underlying keratinocyte / ECM remodelling during wound repair.
[Matrix Biology]
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Clinical Trials of Cryopreserved Umbilical Cord TTAX01 Allograft to Treat Complex Wagner Grade III-IV Diabetic Foot Ulcers

Amniox Medical, Inc announced the initiation of the first of two planned multi center randomized controlled phase III clinical trials that will be conducted at 20 investigational sites across the U.S with an enrollment of 220 patients in each trial. These trials will study the benefits and risks of using TTAX01 to achieve complete wound closure of complex non-healing diabetic foot ulcers with high-risk factors of ulcer depth indicating exposed bone, tendon, muscle, and/or joint capsule, and clinical suspicion of osteomyelitis.
[Amniox]
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Burns in the Elderly: Potential Role of Stem Cells

The authors review the potential use of stem cells in elderly burn wounds, as well as the mechanisms by which mesenchymal stem cell- based therapies may impact burn wound healing in the elderly.
[International Journal of Molecular Sciences]
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Phenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway

Researchers demonstrated that phenformin suppressed tumor growth and promoted keratinocyte differentiation in the DMBA/TPA two stage skin carcinogenesis mouse model.
[Journal of investigative Dermatology]
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Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma-Like Vasculopathy in Klf5+/-; Fli1+/- Mice

Neovascularization and angiogenesis were assessed by in vivo Matrigel plug assay and in vitro tube formation assay, respectively.
[Arthritis & Rheumatology]
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