Keep Current with the Latest in Cell Biology Research
Scientists found no difference in the percentage of dying cells in immunodeficient dystrophic mouse muscles at the times after the irradiation dose that enhanced donor cell engraftment.
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Differential expression analysis identified transcriptional profiles altered in the activated muscle stem/progenitor cells including genes associated with aging, obesity, diabetes, and impaired muscle regeneration, as well as long non-coding RNAs previously undescribed in human myogenic cells.
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Vascular smooth muscle cells (VSMCs) undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 and granulocyte-macrophage colony stimulating factor, leading to their secretion.
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The authors provide an overview of the beneficial adaptive responses to exercise and details the molecular mechanisms involved. The possibility of designing therapeutic interventions based on these molecular mechanisms is addressed, using relevant examples that have exploited this approach.
[Nature Reviews Endocrinology]
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Sarepta Therapeutics, Inc. announced an agreement with Hansa Biopharma, the leader in immunomodulatory enzyme technology for rare Immunoglobulin G mediated diseases, for imlifidase.
Loxosceles laeta venom, as well as sphingomyelinase D, increased intracellular superoxide levels, leading to DNA damage in human keratinocytes.
[Archives of Toxicology]
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By directly recruiting both syndecan-1 and CD44, laminin-332 G45 domain played a major role in regulating mechanisms underlying keratinocyte / ECM remodelling during wound repair.
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Amniox Medical, Inc announced the initiation of the first of two planned multi center randomized controlled phase III clinical trials that will be conducted at 20 investigational sites across the U.S with an enrollment of 220 patients in each trial. These trials will study the benefits and risks of using TTAX01 to achieve complete wound closure of complex non-healing diabetic foot ulcers with high-risk factors of ulcer depth indicating exposed bone, tendon, muscle, and/or joint capsule, and clinical suspicion of osteomyelitis.
The authors review the potential use of stem cells in elderly burn wounds, as well as the mechanisms by which mesenchymal stem cell- based therapies may impact burn wound healing in the elderly.
[International Journal of Molecular Sciences]
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Researchers demonstrated that phenformin suppressed tumor growth and promoted keratinocyte differentiation in the DMBA/TPA two stage skin carcinogenesis mouse model.
[Journal of investigative Dermatology]
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Neovascularization and angiogenesis were assessed by in vivo Matrigel plug assay and in vitro tube formation assay, respectively.
[Arthritis & Rheumatology]