[Nucleic Acids Research] Investigators demonstrated that in heart failure patient cardiomyocytes, telomeres were shortened compared to healthy controls.

[Scientific Reports] The authors elucidated the mechanisms by which myopathy and dilated cardiomyopathy develop using the murine myoblast cell line C2C12 and disease-specific human induced pluripotent stem cells.

[Nature] Scientists found that activation of the pore-forming protein GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11, but not by TLR4-induced cytokines, mediated BBB breakdown in response to circulating LPS or during LPS-induced sepsis.

[Cancer Gene Therapy] Researchers screened for differentially expressed genes in osteosarcoma. They found that osteosarcoma cases could be divided into fair and poor survival groups based on gene expression profiles.

[Cell Death & Disease] Caspase 8 (Casp8) is a master regulator of pyroptosis, apoptosis, and necroptosis (PANoptosis). To study the role of PANoptosis in hematopoiesis, scientists generated inducible Casp8 knockout mice.

[Developmental Cell] To understand how metabolism impacted early mesoderm development, scientists used mESC-derived gastruloids, that co-expressed glucose transporters with the mesodermal marker T/Bra.

[Journal Of Clinical Investigation] In a single-center prospective cohort of intubated pediatric acute respiratory distress syndrome, investigators collected plasma on days zero, three, and seven. Nineteen biomarkers reflecting inflammation, tissue injury, and damage associated molecular patterns were measured.

[Cell Death & Disease] Researchers found that speckle-type POZ protein (SPOP)n and ELK3 were an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation.

[iScience] The authors investigated the mechanisms underlying the toxicity of punicic acid, an isomer of conjugated linolenic acids bearing three conjugated double bonds highly prone to peroxidation, on prostate cancer cells.

[The Prostate] Nucleolar proteomics data and large-scale immunofluorescence were re-analyzed to jointly identify the proteins localized at nucleolus. RNA-Seq data of five prostate cancer (PCa) cohorts were combined and integrated with multi-dimensional data to define the upregulated nucleolar transcription factors in PCa tissues.

[McGill University Health Centre] The Research Institute of McGill University Health Centre has enrolled the first patients to take part in an early-stage, multi-centre clinical trial of Actinium-225, a radioactive isotope used as a treatment for metastatic prostate cancer.

[The University of Queensland] Dr Kevin Koo, from The University of Queensland’s (UQ) Centre for Clinical Research, has been awarded one of five new research grants worth a combined value of $1.2 million from the Prostate Cancer Foundation of Australia.