Keep Current with the Latest in Cell Biology Research

Thymic Development of Unconventional T Cells: How NKT Cells, MAIT Cells and γδ T Cells Emerge

Scientists describe the thymic development of NK T cells, mucosal-associated invariant T (MAIT) cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.
[Nature Reviews Immunology]
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Impaired T Cell Responses in Domestic Pigs and Wild Boar upon Infection with a Highly Virulent African Swine Fever Virus Strain

Researchers investigated T cell responses of domestic pigs and wild boar upon infection with the highly virulent ASF virus strain “Armenia08”.
[Transboundary and Emerging Diseases]
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HSF1 Inhibition Attenuates HIV-1 Latency Reversal Mediated by Several Candidate LRAs In Vitro and Ex Vivo

In cells from infected individuals, inhibition of heat shock factor 1 attenuated latency reversal by phorbol ester+ionomycin but not by anti-CD3+anti-CD28.
[Proceedings of the National Academy of Sciences of the United States of America]
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Syrian Hamsters as a Small Animal Model for SARS-CoV-2 Infection and Countermeasure Development

Researchers assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection.
[Proceedings of the National Academy of Sciences of the United States of America]
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TNF Deficiency Dysregulates Inflammatory Cytokine Production, Leading to Lung Pathology and Death during Respiratory Poxvirus Infection

Tumor necrosis factor (TNF) deficiency did not affect viral load or leukocyte recruitment but caused severe lung pathology and excessive production of the cytokines interleukin (IL)-6, IL-10, transforming growth factor beta, and interferon gamma
[Proceedings of the National Academy of Sciences of the United States of America]
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Oligodendrocytes That Survive Acute Coronavirus Infection Induce Prolonged Inflammatory Responses in the CNS

Using a lineage-tracking system, investigators showed that some cells, primarily oligodendrocytes and oligodendrocyte precursor cells, survived the acute mouse hepatitis infection, were associated with regions of demyelination, and persisted in the central nervous system for at least 150 days.
[Proceedings of the National Academy of Sciences of the United States of America]
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GM-CSF-Based Treatments in COVID-19: Reconciling Opposing Therapeutic Approaches

Granulocyte–macrophage colony-stimulating factor, a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials.
[Nature Reviews Immunology]
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TLR2 on Blood Monocytes Senses Dengue Virus Infection and Its Expression Correlates with Disease Pathogenesis

Scientists demonstrated that TLR2, together with its co-receptors CD14 and TLR6, was an innate sensor of Dengue virus particles inducing inflammatory cytokine expression and impairing vascular integrity in vitro.
[Nature Communications]
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Mateon Therapeutics Selects IQVIA for Its Randomized, Controlled, Multi-Center Clinical Study to Test OT-101 as a Treatment for COVID-19 Patients

Mateon Therapeutics has selected IQVIA to manage C001, a Phase II randomized, controlled, multi-center clinical study of OT-101.
[Mateon Therapeutics]
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Sanofi and Translate Bio Expand Collaboration to Develop mRNA Vaccines Across All Infectious Disease Areas

Sanofi Pasteur and Translate Bio have agreed to expand their existing 2018 collaboration and license agreement to develop mRNA vaccines for infectious diseases.
[Sanofi]
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Neutrophils Use Selective Autophagy Receptor Sqstm1/p62 to Target Staphylococcus aureus for Degradation In Vivo in Zebrafish

Investigators determined the fate and location of S. aureus within neutrophils throughout zebrafish infection.
[Journal of Autophagy]
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