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AB Science Announces the Signing of an Exclusive Licensing Agreement with the University of Chicago to Conduct Research for the Prevention and Treatment of COVID-19

AB Science SA announced the signing of an exclusive licensing agreement for conducting research on the prevention and treatment of humans infected with nidoviruses, coronaviruses and picornaviruses.
[AB Science SA (Globe Newswire, Inc.)]
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Calcineurin Inhibitors Suppress Acute Graft-vs-Host Disease via NFAT-Independent Inhibition of T Cell Receptor Signaling

Researchers utilized T cells from mice that express LckS59A, which cannot accept a phosphate at residue 59, to initiate acute graft-versus-host disease.
[Journal of Clinical Investigation]
Otsuka, S., Melis, N., Gaida, M. M., Dutta, D., Weigert, R., & Ashwell, J. D. (2021). Calcineurin inhibitors suppress acute graft-vs-host disease via NFAT-independent inhibition of T cell receptor signaling. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI147683 Cite
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A Distal Foxp3 Enhancer Enables Interleukin-2 Dependent Thymic Treg Cell Lineage Commitment for Robust Immune Tolerance

The authors report that IL-2 – STAT5 signaling converged on an enhancer during Foxp3 induction.
[Immunity]
Dikiy, S., Li, J., Bai, L., Jiang, M., Janke, L., Zong, X., Hao, X., Hoyos, B., Wang, Z.-M., Xu, B., Fan, Y., Rudensky, A. Y., & Feng, Y. (2021). A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.03.020 Cite
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Organoid Modeling of Zika and Herpes Simplex Virus 1 Infections Reveals Virus-Specific Responses Leading to Microcephaly

Scientists used human brain organoids to study the mechanisms underlying microcephaly caused by Zika virus and herpes simplex virus.
[Cell Stem Cell]
Krenn, V., Bosone, C., Burkard, T. R., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Christoff, R. R., Garcez, P. P., Mirazimi, A., & Knoblich, J. A. (2021). Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.03.004 Cite
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Systemic Immunity in Cancer

Emerging evidence suggests that immunotherapy drives new immune responses rather than the reinvigoration of pre-existing immune responses. Scientists comprehensively outline the current knowledge of systemic immunity in cancer.
[Nature Reviews Cancer]
Hiam-Galvez, K. J., Allen, B. M., & Spitzer, M. H. (2021). Systemic immunity in cancer. Nature Reviews Cancer, 1–15. https://doi.org/10.1038/s41568-021-00347-z Cite
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Integrative Bulk and Single-Cell Profiling of Pre-manufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy

The authors extensively characterized the pre manufacture T-cells of 71 patients with B-cell malignancies on trial to receive anti-CD19 CAR T-cell therapy.
[Cancer Discovery]
Chen, G. M., Chen, C., Das, R. K., Gao, P., Chen, C.-H., Bandyopadhyay, S., Ding, Y.-Y., Uzun, Y., Yu, W., Zhu, Q., Myers, R. M., Grupp, S. A., Barrett, D. M., & Tan, K. (2021). Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-1677 Cite
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Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

Scientists demonstrated that salinomycin displayed potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In pre-clinical studies, salinomycin prevented cardiac fibrosis and functional decline in mouse models of ischemic and non-ischemic heart disease.
[Circulation Research]
Burke Ryan M, Dirkx, Jr. R. A., Quijada Pearl, Lighthouse Janet K, Mohan Amy, O’Brien Meghann, Wojciechowski Wojciech, Woeller Collynn, Phipps Richard P, Alexis Jeffrey D, Ashton John, & Small Eric M. (n.d.). Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317791 Cite
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Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity.
[Clinical Cancer Research]
Taki, M., Abiko, K., Ukita, M., Murakami, R., Yamanoi, K., Yamaguchi, K., Hamanishi, J., Baba, T., Matsumura, N., & Mandai, M. (2021). Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4459 Cite
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Feedback Activation of NF-KB Signaling Leads to Adaptive Resistance to EZH2 Inhibitors in Prostate Cancer Cells

Scientists revealed a EZH2-SOX9-TNFRSF11A axis in the regulation of activity of NF-κB signaling in prostate cancer cells.
[Cancer Cell International]
Jin, M., Duan, J., Liu, W., Ji, J., Liu, B., & Zhang, M. (2021). Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells. Cancer Cell International, 21(1), 191. https://doi.org/10.1186/s12935-021-01897-w Cite
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Tau Oligomers Accumulation Sensitizes Prostate Cancer Cells to Docetaxel Treatment

The authors investigated the potential association between autophagy and tau oligomers accumulation and its role in the response of prostate cancer cells to docetaxel.
[Journal of Cancer Research and Clinical Oncology]
Martellucci, S., Clementi, L., Sabetta, S., Muzi, P., Mattei, V., Bologna, M., & Angelucci, A. (2021). Tau oligomers accumulation sensitizes prostate cancer cells to docetaxel treatment. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-021-03598-3 Cite
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Inhibition of STAT3 Prevents Bone Metastatic Progression of Prostate Cancer In Vivo

Effects of signal transducer and activator of transcription 3 (STAT3) inhibitors, Stattic and Napabucasin, on metastatic potential in prostate cancer cells were studied in vitro by assessment of migration capacity, self‐renewal potential, and tumorsphere formation.
[Prostate]
Thulin, M. H., Määttä, J., Linder, A., Sterbova, S., Ohlsson, C., Damber, J.-E., Widmark, A., & Persson, E. (n.d.). Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24125 Cite
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