Keep Current with the Latest in Cell Biology Research

Systemic and Mucosal Immune Profiling in Asymptomatic and Symptomatic SARS-CoV-2–Infected Individuals Reveal Unlinked Immune Signatures

The authors evaluated systemic and mucosal immune signatures in asymptomatic SARS-CoV-2–infected versus symptomatic COVID-19 adults compared with RSV-infected adults.
[Science Advances]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Insertional Activation of STAT3 and LCK by HIV-1 Proviruses in T Cell Lymphomas

Scientists showed that HIV-1 proviruses integrated in the first introns of signal transducer and activator of transcription 3 and lymphocyte-specific protein tyrosine kinase could play an important role in the development of T cell lymphomas.
[Science Advances]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Immunodominant Linear B Cell Epitopes in the Spike and Membrane Proteins of SARS-CoV-2 Identified by Immunoinformatics Prediction and Immunoassay

Three immunodominant linear B cell epitopes in the SARS-CoV-2 spike receptor-binding domain (RBD) were identified by immunoinformatics prediction, and confirmed by ELISA with sera from Macaca fascicularis vaccinated with a SARS-CoV-2 RBD subunit vaccine.
[Scientific Reports]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Evidence That Two Instead of One Defective Interfering RNA in Influenza a Virus-Derived Defective Interfering Particles (DIPs) Does Not Enhance Antiviral Activity

Investigators demonstrated the successful production of DIPs harboring deletions in segments 1 and/or 3, using cell lines that co-expressed PB2 and PA.
[Scientific Reports]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

INO-4800 DNA Vaccine Induces Neutralizing Antibodies and T Cell Activity against Global SARS-CoV-2 Variants

Researchers compared humoral and cellular responses against SARS-CoV-2 variants of concern in subjects immunized with the DNA vaccine, INO-4800.
[npj Vaccines]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Effect of Delta Variant on Viral Burden and Vaccine Effectiveness against New SARS-CoV-2 Infections in the UK

Scientists found that the effectiveness of BNT162b2 and ChAdOx1 against infections with symptoms or high viral burden was reduced with the B.1.617.2 variant compared to the B.1.1.7 variant.
[Nature Medicine]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Control of Host Mitochondria by Bacterial Pathogens

The authors discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.
[Trends in Microbiology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Merck Receives Positive CHMP Opinion for VAXNEUVANCE™ (Pneumococcal 15-valent Conjugate Vaccine) in Individuals 18 Years of Age and Older

Merck announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended the approval of VAXNEUVANCE™ for active immunization for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae in individuals 18 years of age and older.
[Merck (BusinessWire, Inc.)]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Moderna Announces FDA Advisory Committee Unanimously Votes in Support of Emergency Use for a Booster Dose of Moderna’s COVID-19 Vaccine in the US

Moderna, Inc. confirmed that the FDA Vaccines and Related Biological Products Advisory Committee recommended that the FDA grant an Emergency Use Authorization for a booster dose of the Moderna COVID-19 vaccine at the 50 µg dose level for people aged 65 and older; people aged 18 to 64 who are at high risk of severe COVID-19; and people aged 18 to 64 whose exposure to COVID-19 puts them at risk for COVID-19 complications or severe illness.
[Moderna, Inc.]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Small Molecule Compound M12 Reduces Vascular Permeability in Obese Mice via Blocking Endothelial TRPV4–Nox2 Interaction

The authors showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.
[Acta Pharmacologica Sinica]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

Recent advances in bioinspired delivery platforms for cancer vaccines, existing obstacles faced, as well as insights and future directions for the field are discussed.
[Advanced Materials]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share