Keep Current with the Latest in Cell Biology Research
Investigators developed a one‐size‐fits‐all editing strategy for effective T‐cell correction, selection, and depletion and investigated the therapeutic potential of T‐cell and hematopoietic stem/progenitor cell therapies in the hyper‐IgM syndrome mouse model.
[EMBO Molecular Medicine]
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Vavassori, V., Mercuri, E., Marcovecchio, G. E., Castiello, M. C., Schiroli, G., Albano, L., Margulies, C., Buquicchio, F., Fontana, E., Beretta, S., Merelli, I., Cappelleri, A., Rancoita, P. M., Lougaris, V., Plebani, A., Kanariou, M., Lankester, A., Ferrua, F., Scanziani, E., … Genovese, P. (2021). Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome. EMBO Molecular Medicine, n/a(n/a), e13545. https://doi.org/10.15252/emmm.202013545 Cite
Through an RNAi screen performed on genes involved in chromosomal instability and overexpressed in human lung adenocarcinoma samples, scientists identified the cytoskeleton-associated protein 2-like as a potential oncogene that promotes lung cancer proliferation and growth in vitro and in vivo.
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Monteverde, T., Sahoo, S., Montagna, M. L., Magee, P., Shi, L., Lee, D., Sellers, R., Baker, A. R., Leong, H. S., Fassan, M., & Garofalo, M. (2021). CKAP2L promotes non-small cell lung cancer progression through regulation of transcription elongation. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1968 Cite
Scientists report that eukaryotic protein translation elongation factor 1α2 (EEF1A2) mediates the epithelial–mesenchymal transformation, to promote the metastasis of lung adenocarcinoma cells in vitro and in vivo.
[British Journal of Cancer]
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Jia, L., Ge, X., Du, C., Chen, L., Zhou, Y., Xiong, W., Xiang, J., Li, G., Xiao, G., Fang, L., & Li, Z. (2021). EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-β/SMAD signalling. British Journal of Cancer, 1–11. https://doi.org/10.1038/s41416-020-01250-4 Cite
The authors tested the hypothesis that β2‐adrenergic receptor stimulation produces a cAMP signal that is unable to reach sarco/endoplasmic reticulum Ca2+‐ATPase 2, and determine what role, if any, phosphodiesterase activity plays in this compartmentation.
[British Journal of Pharmacology]
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Rudokas, M. W., Post, J. P., Sataray‐Rodriguez, A., Sherpa, R. T., Moshal, K. S., Agarwal, S. R., & Harvey, R. D. (n.d.). Compartmentation of β2-Adrenergic Receptor Stimulated cAMP Responses by Phosphodiesterases Type 2 and 3 in Cardiac Ventricular Myocytes. British Journal of Pharmacology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bph.15382 Cite
Lixte Biotechnology Holdings, Inc. announced an agreement on a Phase Ib clinical trial with City of Hope, a world-renowned independent cancer research and treatment center. The trial will assess the combination of Lixte’s first-in-class protein phosphatase inhibitor LB-100 with a standard regimen for untreated, extensive stage-disease small cell lung cancer.
[Lixte Biotechnology Holdings, Inc. (GlobeNewswire, Inc.)]
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Researchers investigated the intracellular mechanism of glucagon-like peptide-1 (GLP-1) synthesis in L cells from the perspective of miRNA. They found that GLP-1 level was down-regulated in the plasma and ileum tissues of obese mice, while the ileac miR-194 expression was up-regulated.
[Cell Death & Disease]
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Wang, J., Zhao, D., Ding, C.-Z., Guo, F., Wu, L.-N., Huang, F.-J., Liu, Y.-L., Zhao, S.-Y., Xin, Y., Ma, S.-N., Ji, H.-F., Wang, X., & Wei, L.-R. (2021). MicroRNA-194: a novel regulator of glucagon-like peptide-1 synthesis in intestinal L cells. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03366-0 Cite
Using tumor expression data and non-negative matrix factorization, scientists identified four small cell lung cancer (SCLC) subtypes defined largely by differential expression of transcription factors ASCL1, NEUROD1, and POU2F3 or low expression of all three transcription factor signatures accompanied by an Inflamed gene signature.
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Gay, C. M., Stewart, C. A., Park, E. M., Diao, L., Groves, S. M., Heeke, S., Nabet, B. Y., Fujimoto, J., Solis, L. M., Lu, W., Xi, Y., Cardnell, R. J., Wang, Q., Fabbri, G., Cargill, K. R., Vokes, N. I., Ramkumar, K., Zhang, B., Corte, C. M. D., … Byers, L. A. (2021). Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.12.014 Cite
The authors explored whether enhancer of zeste homolog 2-mediated paired box 8 methylation affects gastrointestinal stromal tumor (GIST) development through regulation of Wnt4. A total of 50 cases of GIST tissues were collected and the human GIST cell lines were cultured.
[Cancer Gene Therapy]
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Genentech announced that the FDA has accepted the company’s supplemental New Drug Application and granted Priority Review for Esbriet® for the treatment of unclassifiable interstitial lung disease.
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Scientists discuss the latest culture techniques and technological approaches to obtain functional platelets and erythrocytes ex vivo.
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Cairnsurgical, Inc. announced that the first patient has been treated in its US pivotal trial of the Breast Cancer Locator System at Massachusetts General Hospital.
[Cairnsurgical, Inc. (Business Wire, Inc.)]
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