Keep Current with the Latest in Cell Biology Research
AB Science SA announced the signing of an exclusive licensing agreement for conducting research on the prevention and treatment of humans infected with nidoviruses, coronaviruses and picornaviruses.
[AB Science SA (Globe Newswire, Inc.)]
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Researchers utilized T cells from mice that express LckS59A, which cannot accept a phosphate at residue 59, to initiate acute graft-versus-host disease.
[Journal of Clinical Investigation]
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The authors report that IL-2 – STAT5 signaling converged on an enhancer during Foxp3 induction.
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Dikiy, S., Li, J., Bai, L., Jiang, M., Janke, L., Zong, X., Hao, X., Hoyos, B., Wang, Z.-M., Xu, B., Fan, Y., Rudensky, A. Y., & Feng, Y. (2021). A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.03.020 Cite
Scientists used human brain organoids to study the mechanisms underlying microcephaly caused by Zika virus and herpes simplex virus.
[Cell Stem Cell]
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Krenn, V., Bosone, C., Burkard, T. R., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Christoff, R. R., Garcez, P. P., Mirazimi, A., & Knoblich, J. A. (2021). Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.03.004 Cite
Emerging evidence suggests that immunotherapy drives new immune responses rather than the reinvigoration of pre-existing immune responses. Scientists comprehensively outline the current knowledge of systemic immunity in cancer.
[Nature Reviews Cancer]
The authors extensively characterized the pre manufacture T-cells of 71 patients with B-cell malignancies on trial to receive anti-CD19 CAR T-cell therapy.
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Chen, G. M., Chen, C., Das, R. K., Gao, P., Chen, C.-H., Bandyopadhyay, S., Ding, Y.-Y., Uzun, Y., Yu, W., Zhu, Q., Myers, R. M., Grupp, S. A., Barrett, D. M., & Tan, K. (2021). Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-1677 Cite
Scientists demonstrated that salinomycin displayed potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In pre-clinical studies, salinomycin prevented cardiac fibrosis and functional decline in mouse models of ischemic and non-ischemic heart disease.
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Burke Ryan M, Dirkx, Jr. R. A., Quijada Pearl, Lighthouse Janet K, Mohan Amy, O’Brien Meghann, Wojciechowski Wojciech, Woeller Collynn, Phipps Richard P, Alexis Jeffrey D, Ashton John, & Small Eric M. (n.d.). Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317791 Cite
Epithelial-mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity.
[Clinical Cancer Research]
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Scientists revealed a EZH2-SOX9-TNFRSF11A axis in the regulation of activity of NF-κB signaling in prostate cancer cells.
[Cancer Cell International]
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The authors investigated the potential association between autophagy and tau oligomers accumulation and its role in the response of prostate cancer cells to docetaxel.
[Journal of Cancer Research and Clinical Oncology]
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Effects of signal transducer and activator of transcription 3 (STAT3) inhibitors, Stattic and Napabucasin, on metastatic potential in prostate cancer cells were studied in vitro by assessment of migration capacity, self‐renewal potential, and tumorsphere formation.
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Thulin, M. H., Määttä, J., Linder, A., Sterbova, S., Ohlsson, C., Damber, J.-E., Widmark, A., & Persson, E. (n.d.). Inhibition of STAT3 prevents bone metastatic progression of prostate cancer in vivo. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24125 Cite