Keep Current with the Latest in Cell Biology Research

Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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T-Regulatory Cells Predict Clinical Outcome in Soft Tissue Sarcoma Patients: A Clinico-Pathological Study

Investigators analyzed tumor-infiltrating lymphocytes and immune checkpoint molecules in soft tissue sarcomas, and assessed their prognostic impact regarding local recurrence, distant metastasis, and overall survival.
[British Journal of Cancer]
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STAG2 Loss Rewires Oncogenic and Developmental Programs to Promote Metastasis in Ewing Sarcoma

The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological role is less clear. The authors demonstrated that cohesin complexes containing STAG2 occupy enhancer and polycomb repressive complex-marked regulatory regions.
[Cancer Cell]
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Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

Essent Biologics has announced the launch of its human MSCs for regenerative medicine, biopharmaceutical and cell therapy research. Essent Biologics will provide highly-characterized, low-passaged human MSCs.
[Essent Biologics]
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Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]
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Dissecting the Multi-Omics Atlas of the Exosomes Released by Human Lung Adenocarcinoma Stem-Like Cells

Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. The authors presented a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
[npj Genomic Medicine]
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IMBRUVICA® (Ibrutinib) Plus VENCLEXTA®/VENCLYXTO® (Venetoclax) Combination Shows Superior Progression-Free Survival Compared to Chlorambucil Plus Obinutuzumab in First-line Chronic Lymphocytic Leukemia (CLL) Phase III GLOW Study

AbbVie, Inc. announced new data from the Phase III GLOW study comparing the efficacy and safety of the combination of IMBRUVICA® plus VENCLEXTA®/VENCLYXTO® versus chlorambucil plus obinutuzumab for first-line treatment in patients with CLL or small lymphocytic lymphoma who had active disease requiring treatment per the International Workshop on CLL criteria.
[AbbVie, Inc.]
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Pseudogene ACTBP2 Increases Blood-Brain Barrier Permeability by Promoting KHDRBS2 Transcription Through Recruitment of KMT2D/WDR5 in Aβ1–42 Microenvironment

Investigators elucidated the function and possible molecular mechanisms of the effect of pseudogene ACTBP2 on the permeability of blood–brain barrier in Aβ1–42 microenvironment.
[Cell Death Discovery]
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Engineered Bridge Protein with Dual Affinity for Bone Morphogenetic Protein-2 and Collagen Enhances Bone Regeneration for Spinal Fusion

Researchers developed a translational protein engineering–based approach to reduce the dose and thereby improve the safety of rhBMP-2 delivered in a collagen sponge, as in InFUSE Bone Graft.
[Science Advances]
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Targeting Androgen Receptor (AR) with Antiandrogen Enzalutamide Increases Prostate Cancer Cell Invasion Yet Decreases Bladder Cancer Cell Invasion via Differentially Altering the AR/circRNA-ARC1/miR-125b-2-3p or miR-4736/PPARγ/MMP-9 Signals

Researchers found targeting androgens/AR with either the recently developed antiandrogen Enzalutamide or AR-shRNAs led to increased prostate cancer cell invasion, yet decreased bladder cancer cell invasion.
[Cell Death & Differentiation]
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Androgen Receptor (AR) Heterogeneity in Prostate Cancer and Therapy Resistance

The authors summarize the androgen receptor heterogeneity across the prostate cancer (PCa) continuum and discuss its impact on PCa response to treatments.
[Cancer Letters]
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