Keep Current with the Latest in Cell Biology Research

Colon Stroma Mediates an Inflammation-Driven Fibroblastic Response Controlling Matrix Remodeling and Healing

Researchers performed single-cell RNA-sequencing of colon-derived stromal cells and identified distinct classes of fibroblasts with gene signatures that were differentially regulated by chronic inflammation, including IL-11–producing inflammatory fibroblasts.
[PLoS Biology]
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Sialic Acid Blockade in Dendritic Cells Enhances CD8+ T Cell Responses by Facilitating High-Avidity Interactions

Scientists established cultures of murine bone marrow-derived dendritic cells that lacked sialic acid expression using a sialic acid-blocking mimetic Ac53FaxNeu5Ac.
[Cellular and Molecular Life Sciences]
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Regulation of Activated T Cell Survival in Rheumatic Autoimmune Diseases

Investigators review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis.
[Nature Reviews Rheumatology]
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Allergy Therapeutics Announces FDA Clearance of IND Application for Novel Peanut Allergy Vaccine Candidate VLP Peanut

Allergy Therapeutics announced that the FDA cleared the group’s Investigational New Drug application (IND) for its novel virus-like particle (VLP)-based peanut allergy vaccine candidate.
[Allergy Therapeutics (GlobeNewswire, Inc.)]
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Mustang Bio Provides an Update on its IND Application for MB-207, a Lentiviral Gene Therapy for Treatment of X-linked Severe Combined Immunodeficiency (“XSCID”) in Previously Transplanted Patients

Mustang Bio, Inc. announced that the FDA has issued a hold, pending Chemistry, Manufacturing and Controls clearance, on the company’s Investigational New Drug application.
[Mustang Bio, Inc.]
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An In Vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-Clinical Animal Models

Researchers described the use of an MSC-based delivery system for the secretion of a ZF protein in transgenic mouse models and young rhesus monkeys.
[Frontiers in Molecular Neuroscience]
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Mesenchymal Stromal Cell-Derived Septoclasts Resorb Cartilage during Developmental Ossification and Fracture Healing

Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells.
[Nature Communications]
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HucMSC Exosomes Promoted Imatinib-Induced Apoptosis in K562-R Cells via a miR-145a-5p/USP6/GLS1 Axis

Administration of human umbilical cord MSC exosomes promoted imatinib-induced cell apoptosis through miR-145a-5p/USP6.
[Cell Death & Disease]
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Tracking Cell Viability for Adipose-Derived Mesenchymal Stem Cell-Based Therapy by Quantitative Fluorescence Imaging in the Second Near-Infrared Window

The authors developed an activated near-infrared II fluorescent nanoparticle consisting of lanthanide-based down-conversion nanoparticles and IR786s for cell labeling and real-time tracking of adipose-derived MSC viability in vivo.
[ACS Nano]
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Brahma Safeguards Canalization of Cardiac Mesoderm Differentiation

Scientists showed that the BRG1/BRM-associated factor chromatin-remodeling complex ATPase gene Brm safeguarded cell identity during directed cardiogenesis of mouse ESCs.
[Nature]
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Characterizing Cellular Heterogeneity in Fibrotic Hypersensitivity Pneumonitis by Single-Cell Transcriptional Analysis

Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, the authors identified ten major cell types and 19 unique subtypes.
[Cell Death Discovery]
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