Keep Current with the Latest in Cell Biology Research

PHF3 Regulates Neuronal Gene Expression through the Pol II CTD Reader Domain SPOC

Scientists identified PHD-finger protein 3 (PHF3) as a regulator of transcription and mRNA stability that docks onto Pol II CTD through its SPOC domain. Key neuronal genes were aberrantly expressed in Phf3 knock-out mouse embryonic stem cells, resulting in impaired neuronal differentiation.
[Nature Communications]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Modifying the m6A Brain Methylome by ALKBH5-Mediated Demethylation: A New Contender for Synaptic Tagging

Researchers demonstrated that at activated glutamatergic post-synaptic sites, both the YTHDF1 and YTHDF3 reader and the ALKBH5 eraser proteins increase in co-localisation to m6A-modified RNAs; but only the readers showed high co-localisation to modified RNAs during late-stage plasticity.
[Molecular Psychiatry]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Lactobacillus rhamnosus and Bifidobacterium longum Alleviate Colitis and Cognitive Impairment in Mice by Regulating IFN-γ to IL-10 and TNF-α to IL-10 Expression Ratios

Intraperitoneal injection of lipopolysaccharide and oral gavage of ampicillin increased IFN-γ and TNF-α expression in the spleen, colon, and hippocampus, while IL-10 expression decreased.
[Scientific Reports]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

ERp29 Forms a Feedback Regulation Loop with microRNA-135a-5p and Promotes Progression of Colorectal Cancer

Researchers showed that ERp29 was a novel target for microRNA-135a-5p to inhibit the progression of colorectal cancer (CRC); correspondingly, ERp29 acted as an oncoprotein in CRC by promoting proliferation and metastasis of CRC cells, and suppressing apoptosis of the cells.
[Cell Death & Disease]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Complete Loss of miR-200 Family Induces EMT Associated Cellular Senescence in Gastric Cancer

Genetic deletion of all miR-200s in the human GC cell lines induced potent morphological alterations, G1/S cell cycle arrest, increased senescence-associated β-galactosidase (SA-β−Gal) activity, and aberrant metabolism, collectively resembling the senescent phenotype.
[Oncogene]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

BRD9 Inhibition Promotes PUMA-Dependent Apoptosis and Augments the Effect of Imatinib in Gastrointestinal Stromal Tumors

Scientists evaluated the functional role of BRD9 in Gastrointestinal stromal tumors (GIST) progression. Their findings demonstrated that the expression of BRD9 was upregulated in GIST tissues.
[Cell Death & Disease]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Smoc1 and Smoc2 Regulate Bone Formation as Downstream Molecules of Runx2

To address the roles played by Runx2-regulated genes in bone formation, investigators identified Runx2 targets by performing RNA-sequencing and found Smoc1 and Smoc2 upregulation by Runx2.
[Communications Biology]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Dissecting the Relationship between Antimicrobial Peptides and Mesenchymal Stem Cells

The authors discuss the production of antimicrobial peptides by MSCs, revise the multiple functions of these peptides, including their influence over MSCs, and present an overview of clinical situations in which the antimicrobial properties of MSCs may be explored for therapy.
[Pharmacology & Therapeutics]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Ambulero’s Gene Therapy Candidate AMB-301 Granted US Orphan Drug Designation for Treatment of Severe Vascular Disease

Ambulero, Inc. announced that the US FDA’s Office For Orphan Products Development granted the company’s request for orphan drug status for its gene therapy candidate, AMB-301, to treat Buerger’s Disease, also known as Thromboangiitis Obliterans.
[Ambulero, Inc.]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

A Neutralizing IL-11 Antibody Reduces Vessel Hyperplasia in a Mouse Carotid Artery Wire Injury Model

Given the proliferation and adhesion defect of Trpm7−/− trophoblast stem cells and the ability of Trpm7−/− ESCs to develop to embryos in tetraploid embryo complementation assays, researchers postulated a critical role of TRPM7 in trophectoderm cells.
[Cell Reports]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Integrated Computational Analyses Reveal Novel Insights into the Stromal Microenvironment of SHH-Subtype Medulloblastoma

The authors elucidated the role of the stromal microenvironment in SHH-subgroup medulloblastoma and identified novel treatment possibilities for this challenging disease.
[Scientific Reports]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share