Keep Current with the Latest in Cell Biology Research

Vpr Counteracts the Restriction of LAPTM5 to Promote HIV-1 Infection in Macrophages

Investigators reported that Vpr counteracts lysosomal-associated transmembrane protein 5 (LAPTM5), a potent inhibitor of HIV-1 particle infectivity, to enhance HIV-1 infection in macrophages.
[Nature Communications]
Zhao, L., Wang, S., Xu, M., He, Y., Zhang, X., Xiong, Y., Sun, H., Ding, H., Geng, W., Shang, H., & Liang, G. (2021). Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages. Nature Communications, 12(1), 3691. https://doi.org/10.1038/s41467-021-24087-8 Cite
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Cell-Mimicking Nanodecoys Neutralize SARS-CoV-2 and Mitigate Lung Injury in a Non-human Primate Model of COVID-19

Scientists showed that ACE2 nanodecoys derived from human lung spheroid cells could bind and neutralize SARS-CoV-2 and protect the host lung cells from infection.
[Nature Nanotechnology]
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Role of DAMPs in Respiratory Virus-Induced Acute Respiratory Distress Syndrome—with a Preliminary Reference to SARS-CoV-2 Pneumonia

The similar role of DAMPs is addressed, that is, of those molecules, which operate upstream of the inflammatory pathway by activating those cells, which ultimately release the cytokines.
[Genes & Immunity]
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Extracellular Vesicles from Human iPSCs Enhance Reconstitution Capacity of Cord Blood-Derived Hematopoietic Stem and Progenitor Cells

Scientists demonstrated that hiPSC-extracellular vesicles improved functional properties of cord blood-HSPCs critical for their hematopoietic capacity including metabolic, hematopoietic and clonogenic potential as well as survival, chemotactic response to stromal cell-derived factor 1 and adhesion to the model components of hematopoietic niche in vitro.
[Leukemia]
Karnas, E., Sekuła-Stryjewska, M., Kmiotek-Wasylewska, K., Bobis-Wozowicz, S., Ryszawy, D., Sarna, M., Madeja, Z., & Zuba-Surma, E. K. (2021). Extracellular vesicles from human iPSCs enhance reconstitution capacity of cord blood-derived hematopoietic stem and progenitor cells. Leukemia, 1–14. https://doi.org/10.1038/s41375-021-01325-y Cite
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One Repeated Transplantation of Allogeneic Umbilical Cord Mesenchymal Stromal Cells in Type 1 Diabetes: An Open Parallel Controlled Clinical Study

Scientists examined the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with type 1 diabetes.
[Stem Cell Research & Therapy]
Lu, J., Shen, S., Ling, Q., Wang, B., Li, L., Zhang, W., Qu, D., Bi, Y., & Zhu, D. (2021). One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study. Stem Cell Research & Therapy, 12(1), 340. https://doi.org/10.1186/s13287-021-02417-3 Cite
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Placental Chorionic Plate-Derived Mesenchymal Stem Cells Ameliorate Severe Acute Pancreatitis by Regulating Macrophage Polarization via Secreting TSG-6

The survival and colonization of exogenous placental chorionic plate-derived MSCs were observed by bioluminescence imaging and CM-Dil labeling in rodent animal models of severe acute pancreatitis.
[Stem Cell Research & Therapy]
Huang, Q., Cheng, X., Luo, C., Yang, S., Li, S., Wang, B., Yuan, X., Yang, Y., Wen, Y., Liu, R., Tang, L., & Sun, H. (2021). Placental chorionic plate-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating macrophage polarization via secreting TSG-6. Stem Cell Research & Therapy, 12(1), 337. https://doi.org/10.1186/s13287-021-02411-9 Cite
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Circular RNA AFF4 Modulates Osteogenic Differentiation in BM-MSCs by Activating SMAD1/5 Pathway through miR-135a-5p/FNDC5/Irisin Axis

Researchers investigated molecular mechanisms underlying circular RNA AFF4-regulated Bone marrow-derived-MSCs osteogenesis.
[Cell Death & Disease]
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Circ_0008542 in Osteoblast Exosomes Promotes Osteoclast-Induced Bone Resorption through m6A Methylation

Scientists showed that exosomes containing circ_0008542 from MC3T3-E1 cells with prolonged tensile stimulation promoted osteoclast differentiation and bone resorption.
[Cell Death & Disease]
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The Effect of Parathyroid Hormone on Osteogenesis Is Mediated Partly by Osteolectin

Parathyroid hormone (PTH) and sclerostin inhibitor (SOSTi) are bone anabolic agents that are administered to patients with osteoporosis. Scientists tested whether osteolectin mediates the effects of PTH or SOSTi on bone formation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Localized Chondro-Ossification Underlies Joint Dysfunction and Motor Deficits in the Fkbp10 Mouse Model of Osteogenesis Imperfecta

The pathogenic mechanisms underlying joint dysfunction in osteogenesis imperfecta are poorly understood. The authors generated a mouse model in which Fkbp10 was conditionally deleted in tendons and ligaments.
[Proceedings of the National Academy of Sciences of the United States of America]
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Vimentin Intermediate Filaments Stabilize Dynamic Microtubules by Direct Interactions

The authors showed in a reconstituted in vitro system that vimentin intermediate filaments stabilized microtubules against depolymerization and supported microtubule rescue.
[Nature Communications]
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