Keep Current with the Latest in Cell Biology Research

Targeting HER2+ Breast Cancer Brain Metastases: A Review of Brain-Directed HER2-Directed Therapies

HER2-targeted therapies, including antibody-drug conjugates, have presented new therapeutic options for this patient population; however, additional data for both small-molecule inhibitors and antibody-drug conjugates with respect to patients with central nervous system metastases is needed. Scientists specifically review the data for the management of HER2+ parenchymal brain metastases.
[CNS Drugs]
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Therapeutic Effects of TM4SF5-Targeting Chimeric and Humanized Monoclonal Antibodies in Hepatocellular and Colon Cancer Models

The authors evaluated the effects of chimeric Ab27 using cancer cells expressing endogenous transmembrane 4 L six family member 5 (TM4SF5) or stably overexpressing TM4SF5 in vivo and in vitro.
[Molecular Therapy-Oncolytics]
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Melatonin Is a Potential Oncostatic Agent to Inhibit HepG2 Cell Proliferation through Multiple Pathways

Researchers investigated melatonin’s antitumor molecular mechanisms to inhibit the proliferation of HepG2 cells.
[Heliyon]
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Is It Time for Chronopharmacology in NASH?

Scientists describe the potential for chronopharmacology in non-alcoholic steatohepatitis (NASH), discuss how the major NASH drug candidates are influenced by circadian biology, and encourage greater consideration of the timing of drug administration in the design of future clinical trials.
[Journal of Hepatology]
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A Medium Composition Containing Normal Resting Glucose That Supports Differentiation of Primary Human Airway Cells

Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.
[Scientific Reports]
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Targeting S100A9-ALDH1A1-Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer

Using metastatic models of EGFR-mutant lung cancer, the authors showed that cancer cells expressing high intracellular S100A9 escaped osimertinib and initiated brain relapses.
[Cancer Discovery]
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Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non–small Cell Lung Cancer PDX Models with Driver Genetic Alterations

Scientists selected five NSCLC patient-derived xenografts (PDXs) with genetic alterations from established PDXs and the corresponding molecular targeted therapy was administered orally for 21 consecutive days.
[Molecular Cancer therapeutics]
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Metabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors

Researchers found that the metabolites most enriched during the differentiation from pluripotent stem cell to lung progenitor cell, regardless of cell line, were sphingomyelins and phosphatidylcholines, two important lipid classes in lung development.
[iScience]
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Treatment of Kidney Clear Cell Carcinoma, Lung Adenocarcinoma and Glioblastoma Cell Lines with Hydrogels Made of DNA Nanostars

Investigators studied the biological response of three different cell lines to the treatment with DNA-GEL – a DNA-based hydrogel composed of interacting DNA nanostars.
[Biomaterials Science]
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Human Embryonic Mesenchymal Lung-Conditioned Medium Promotes Differentiation to Myofibroblast and Loss of Stemness Phenotype in Lung Adenocarcinoma Cell Lines

The authors reported that stimuli from the embryonic lung could modulate the malignant phenotype of lung cancer cells, control their growth capacity and activate their differentiation into myofibroblasts.
[Journal of Experimental & Clinical Cancer Research]
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Extracellular Vesicle-Mediated Cellular Crosstalk in Lung Repair, Remodeling and Regeneration

The authors highlight the extracellular vesicle (EV)-mediated cellular crosstalk that regulates lung homeostasis and discuss the potential of EV therapeutics for lung regenerative medicine.
[European Respiratory Review]
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