Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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Mir34a Constrains Pancreatic Carcinogenesis

Investigators showed that the accelerated phenotype is driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells.
[Scientific Reports]
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BAP1 Is a Haploinsufficient Tumor Suppressor Linking Chronic Pancreatitis to Pancreatic Cancer in Mice

Researchers found that heterozygous loss of histone H2A lysine 119 deubiquitinase BRCA1 Associated Protein-1 associates with a history of chronic pancreatitis and occurs in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.
[Nature Communications]
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Targeting Focal Adhesion Kinase in Cancer Cells and the Tumor Microenvironment

Scientists discuss the role of nuclear focal adhesion kinase (FAK) as a driver for tumor cell survival as well as potential therapeutic strategies to target FAK in both tumors and the tumor microenvironment
[Experimental and Molecular Medicine]
Targeting focal adhesion kinase in cancer cells and the tumor microenvironment | Experimental & Molecular Medicine. (n.d.). Retrieved June 12, 2020, from https://www.nature.com/articles/s12276-020-0447-4 Cite
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Pre-Clinical Evaluation of TYK2 Inhibitors for Human Beta Cell Protection in Type 1 Diabetes

Two TYK2 inhibitors provided by Nimbus Lakshmi Inc, were tested in human insulin-producing EndoC-βH1 cells and human islets to evaluate their effect on interferon-α signaling and beta cell function.
[Diabetes Obesity & Metabolism]
Coomans de Brachène, A., Castela, A., Op de Beeck, A., Mirmira, R. G., Marselli, L., Marchetti, P., Masse, C., Miao, W., Leit, S., Evans-Molina, C., & Eizirik, D. L. (2020). Pre-clinical evaluation of TYK2 inhibitors for human beta cell protection in type 1 diabetes. Diabetes, Obesity and Metabolism, n/a(n/a). https://doi.org/10.1111/dom.14104 Cite
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Electrogenetic Cellular Insulin Release for Real-Time Glycemic Control in Type 1 Diabetic Mice

Focusing on type 1 diabetes, scientists engineered electrosensitive human β cells (Electroβ cells). Wireless electrical stimulation of Electroβ cells inside a custom-built bioelectronic device provided real-time control of vesicular insulin release.
[Science]
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice | Science. (n.d.). Retrieved June 4, 2020, from https://science.sciencemag.org/content/368/6494/993 Cite
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Role of DNA-LL37 Complexes in the Activation of Plasmacytoid Dendritic Cells and Monocytes in Subjects with Type 1 Diabetes

Following in vitro stimulation with DNA-LL37 complexes, type 1 diabetes group demonstrated higher frequency and mean fluorescence intensity of plasmacytoid dendritic cells expressing IFN-α.
[Scientific Reports]
Badal, D., Dayal, D., Singh, G., & Sachdeva, N. (2020). Role of DNA-LL37 complexes in the activation of plasmacytoid dendritic cells and monocytes in subjects with type 1 diabetes. Scientific Reports, 10(1), 8896. https://doi.org/10.1038/s41598-020-65851-y Cite
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Pro-Inflammatory Cytokine Interleukin 1β Disrupts β Cell Circadian Clock Function and Regulation of Insulin Secretion

Scientists provide evidence that the key diabetogenic cytokine IL-1β disrupted functionality of the β cell circadian clock and impaired circadian regulation of glucose-stimulated insulin secretion.
[Endocrinology]
Javeed, N., Brown, M. R., Rakshit, K., Her, T., Sen, S. K., & Matveyenko, A. V. (n.d.). Pro-inflammatory Cytokine Interleukin 1β Disrupts β cell Circadian Clock Function and Regulation of Insulin Secretion. Endocrinology. https://doi.org/10.1210/endocr/bqaa084 Cite
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Acetylation Promotes BCAT2 Degradation to Suppress BCAA Catabolism and Pancreatic Cancer Growth

The lysine 44 mutant promoted branched-chain amino acid catabolism, cell proliferation, and pancreatic tumor growth.
[Signal Transduction and Targeted therapy]
Lei, M.-Z., Li, X.-X., Zhang, Y., Li, J.-T., Zhang, F., Wang, Y.-P., Yin, M., Qu, J., & Lei, Q.-Y. (2020). Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth. Signal Transduction and Targeted Therapy, 5(1), 1–9. https://doi.org/10.1038/s41392-020-0168-0 Cite
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Oncolytic Adenovirus Expressing ST13 Increases Antitumor Effect of TRAIL against Pancreatic Ductal Adenocarcinoma

CD55-ST13-TRAIL had a synergic cell-killing effect compared with CD55-ST13 alone or CD55-TRAIL alone, and the inhibition of pancreatic ductal adenocarcinoma (PDAC) cell metastasis and promotion of apoptosis by triggering EMT and apoptotic pathways in PDAC cells.
[Human Gene therapy]
Oncolytic adenovirus expressing ST13 increases antitumor effect of TRAIL against pancreatic ductal adenocarcinoma | Human Gene Therapy. (n.d.). Retrieved June 4, 2020, from https://www.liebertpub.com/doi/10.1089/hum.2020.024 Cite
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Nicotine Triggers Islet β Cell Senescence to Facilitate the Progression of Type 2 Diabetes

Investigators demonstrated that nicotine induced premature senescence of pancreatic β cells in vitro and in vivo.
[Toxicology]
Sun, L., Wang, X., Gu, T., Hu, B., Luo, J., Qin, Y., & Wan, C. (2020). Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. Toxicology, 441, 152502. https://doi.org/10.1016/j.tox.2020.152502 Cite
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