Beta-Cell Failure in Type 2 Diabetes: Mechanisms, Markers, and Clinical Implications

Researchers discuss the progression of type 2 diabetes mellitus in the context of beta-cell failure and describe how C-peptide testing can be used to assess beta-cell function in primary care practice.
[Postgraduate Medicine]
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Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells

Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays.
[Annals of Biomedical Engineering]
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Mutations in the C1 Element of the Insulin Promoter Lead to Diabetic Phenotypes in Homozygous Mice

Scientists used CRISPR–Cas9 technology to generate mice with mutations in the promoter regions of the insulin I and II genes.
[Communications Biology]
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Fasting Parameters for Estimation of Stimulated β-Cell Function in Islet Transplant Recipients with or without Basal Insulin Treatment

Scientists determined to what extent fasting glycemic indices could estimate stimulated β‐cell function in islet transplant recipients with and without basal insulin.
[American Journal of Transplantation]
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MicroRNA-181c-5p Promotes the Formation of Insulin-Producing Cells from Human Induced Pluripotent Stem Cells by Targeting smad7 and TGIF2

Investigators differentiated human induced pluripotent stem cells into insulin-producing cells in a stepwise process that recapitulated pancreas organogenesis and observed that miR-181c-5p continuously accumulated throughout the entire differentiation process.
[Cell Death & Disease]
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NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T Cell Numbers

To directly assess the role of NKG2D in the pancreas, scientists generated NOD mice that expressed an NKG2D ligand in β-islet cells.
[Diabetes]
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An Unbiased High‐Throughput Drug Screen Reveals a Potential Therapeutic Vulnerability in the Most Lethal Molecular Subtype of Pancreatic Cancer

In multiple in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDAC), spanning human and murine PDAC cells, and orthotopic xenografts, researchers determined that the expression of keratin 17 resulted in a more than two‐fold increase in resistance to Gem and 5‐fluorouracil, key components of current standard‐of‐care chemotherapeutic regimens.
[Molecular Oncology]
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Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways

Researchers showed glutathione S-transferase pi-1 knockdown reduced pancreatic ductal adenocarcinoma (PDAC) cell growth, prolonged the G0/G1 phase, and elevated reactive oxygen species in PDAC cells.
[Cancers]
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Plasma Interleukin-8 Is a Biomarker for TAK1 Activation and Predicts Resistance to Nanoliposomal Irinotecan in Patients with Gemcitabine-Refractory Pancreatic Cancer

In vivo activity of nanoliposomal irinotecan was validated in an orthotopic nude murine model expressing TAK1-specific shRNA. Differential expression profiling revealed the gene coding for interleukin-8 as the most significantly downregulated in shTAK1 pancreatic cancer cell lines.
[Clinical Cancer Research]
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Seven Bridges and the Pancreatic Cancer Action Network Partner to Develop High-Quality, Actionable Cancer Data Platform

Seven Bridges announced that it has been selected by the Pancreatic Cancer Action Network to build a customized, integrated health data platform to accelerate pancreatic cancer research.
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PharmaCyte Biotech Completes Final cGMP Audit of Manufacturing Facility for Pancreatic Cancer Clinical Trial Product

PharmaCyte Biotech, Inc. announced that cGMP Validation, the company’s cGMP consultant, has completed its post manufacturing audit of the manufacturing facility in Thailand and that the facility has successfully passed the audit.
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