SENP2 Regulates Mitochondrial Function and Insulin Secretion in Pancreatic β Cells

Researchers investigated the function of SENP2 in pancreatic β cells by generating a β cell-specific knockout mouse model.
[Experimental and Molecular Medicine]
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Abnormal Exocrine–Endocrine Cell Cross-Talk Promotes β-Cell Dysfunction and Loss in MODY8

Researchers reported the transfer of carboxyl ester lipase proteins from acinar cells to β-cells as a form of cross-talk between exocrine and endocrine cells.
[Nature Metabolism]
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TriSalus Life Sciences Announces Collaboration with the University of Colorado Anschutz Medical Campus to Advance Research on Innovative Immuno-Oncology Treatments for Patients with Liver and Pancreatic Tumors

TriSalus Life Sciences® announced a strategic research collaboration with the University of Colorado Anschutz Medical Campus to advance research of immuno-oncology treatments for patients with liver and pancreatic tumors.
[TriSalus Life Sciences®]
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Sodium Butyrate Potentiates Insulin Secretion from Rat Islets at the Expense of Compromised Expression of β Cell Identity Genes

Overlapping analysis of H3K27Ac ChIP-seq and RNA-seq showed that the inhibitory effect of SB on the expression of multiple β cell identity genes was independent of H3K27Ac.
[Cell Death & Disease]
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PD-L1 and PD-L2 Expression in Pancreatic Ductal Adenocarcinoma and Their Correlation with Immune Infiltrates and DNA Damage Response Molecules

The authors investigated the expression of two PD-1 ligands, PD-L1 and PD-L2, in pancreatic ductal adenocarcinoma, analysed their role in survival, and explored their correlation with clinicopathological features, immune infiltration, and DNA damage response molecules.
[Journal of Pathology Clinical Research]
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IFN-γ Affects Pancreatic Cancer Properties by MACC1-AS1/MACC1 Axis via AKT/mTOR Signaling Pathway

Rescue assays of cells overexpressing Metastasis-related in colon cancer 1 (MACC1)-AS1 and of cells silencing MACC1 were performed and cellular properties and proteins were assessed by the above-mentioned assays as well.
[Clinical and Translational Medicine]
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Exosomes: The Key of Sophisticated Cell–Cell Communication and Targeted Metastasis in Pancreatic Cancer

In pancreatic cancer, exosomes are enriched with multiple signaling molecules that mediate intercellular communication with control of immune suppression, mutual promotion between pancreas stellate cells and pancreatic cancer cells, and reprogramming of normal cells.
[Cell Communication and Signaling]
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Development and Validation of a Novel 3-Gene Prognostic Model for Pancreatic Adenocarcinoma Based on Ferroptosis-Related Genes

Molecular markers play an important role in predicting clinical outcomes in pancreatic adenocarcinoma patients. The 173 samples were divided into 3 categories and a 3-gene signature model was constructed.
[Cancer Cell International]
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MiR-135b-5p Is an Oncogene in Pancreatic Cancer to Regulate GPRC5A Expression by Targeting Transcription Factor KLF4

Scientists probed molecular regulatory mechanism of KLF4 in malignant progression of pancreatic cancer.
[Cell Death Discovery]
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Exposure to Perfluorooctanoic Acid Leads to Promotion of Pancreatic Cancer

Researchers demonstrated that perfluorooctanoic acid induced oxidative stress and focal ductal hyperplasia in the mouse pancreas.
[Carcinogenesis]
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Matrix Remodeling-Associated Protein 8 Is a Marker of a Subset of Cancer-Associated Fibroblasts in Pancreatic Cancer

Analysis of MXRA8 expression in human pancreatic ductal adenocarcinoma samples showed that MXRA8 was differentially co-expressed with other cancer-associated fibroblasts markers.
[Pathology International]
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