Investigators explore and evaluate the current evidence on locoregional treatments for metastatic PDAC.
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Timmer, F. E. F., Geboers, B., Nieuwenhuizen, S., Schouten, E. A. C., Dijkstra, M., de Vries, J. J. J., van den Tol, M. P., Meijerink, M. R., & Scheffer, H. J. (2021). Locoregional Treatment of Metastatic Pancreatic Cancer Utilizing Resection, Ablation and Embolization: A Systematic Review. Cancers, 13(7), 1608. https://doi.org/10.3390/cancers13071608 Cite
The authors discuss the current knowledge of how metformin modulates type 2 diabetes mellitus (T2DM) with respect to the gut microbiome and discuss the prospect of harnessing this mechanism in treating T2DM.
[International Journal of Molecular Sciences]
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Celon Pharma S.A. announced the successful completion of a Phase I trial of its second generation GPR40 agonist, CPL’280. This agent is in development for the treatment of Diabetes and Diabetic Neuropathy and met its primary endpoint, with no adverse safety signals detected.
[Celon Pharma S.A. (Globe Newswire, Inc)]
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The authors discuss the development of the most widely available insulin preparations and provide evidence-based insight into their use in clinical practice.
Scientists discuss the discoveries that have led to the current understanding of how insulin promotes glucose uptake in muscle.
Investigators discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
Researchers observed state-specific enrichment of fasting glucose and type 2 diabetes genome-wide association studies for beta cells and enrichment for other endocrine cell types.
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Chiou, J., Zeng, C., Cheng, Z., Han, J. Y., Schlichting, M., Miller, M., Mendez, R., Huang, S., Wang, J., Sui, Y., Deogaygay, A., Okino, M.-L., Qiu, Y., Sun, Y., Kudtarkar, P., Fang, R., Preissl, S., Sander, M., Gorkin, D. U., & Gaulton, K. J. (2021). Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk. Nature Genetics, 1–12. https://doi.org/10.1038/s41588-021-00823-0 Cite
Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
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Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite
FGD5-AS1 accelerated cell proliferation and migration via sponging miR-520a-3p and upregulating KIAA1522.
[Cancer Biology & Therapy]
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The authors used single cell RNA sequencing to reveal that AXL was expressed highly in tumor cells that had a mesenchymal-like phenotype and that AXL expression correlated with classic markers of epithelial to mesenchymal transition.
[Molecular Cancer Research]
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Du, W., Phinney, N. Z., Huang, H., Wang, Z., Westcott, J., Toombs, J. E., Zhang, Y., Beg, M. S., Wilkie, T. M., Lorens, J. B., & Brekken, R. A. (2021). AXL is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0860 Cite
Scientists demonstrated that Bcl3 impacted pancreatic carcinogenesis by restraining cancer stem cell expansion and by curtailing an aggressive and metastatic tumor burden in pancreatic ductal adenocarcinoma across species.
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Ai, J., Wörmann, S. M., Görgülü, K., Vallespinos, M., Zagorac, S., Alcala, S., Wu, N., Kabacaoglu, D., Berninger, A., Navarro, D., Kaya-Aksoy, E., Ruess, D. A., Ciecielski, K. J., Kowalska, M., Demir, E. I., Ceyhan, G. O., Heid, I., Braren, R., Riemann, M., … Algül, H. (2021). BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2021.03.051 Cite