Complement Factor B Regulates Cellular Senescence and Is Associated with Poor Prognosis in Pancreatic Cancer

Scientists performed secretome analyses of culture media of mouse pancreatic intraepithelial neoplasia and PDAC cells using Stable Isotope Labeling by Amino acid in Cell culture with click chemistry and liquid chromatography-mass spectrometry.
[Cellular Oncology]
Shimazaki, R., Takano, S., Satoh, M., Takada, M., Miyahara, Y., Sasaki, K., Yoshitomi, H., Kagawa, S., Furukawa, K., Takayashiki, T., Kuboki, S., Sogawa, K., Motohashi, S., Nomura, F., Miyazaki, M., & Ohtsuka, M. (2021). Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer. Cellular Oncology. https://doi.org/10.1007/s13402-021-00614-z Cite
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miR-194-5p Down-Regulates Tumor Cell PD-L1 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer

Investigators found that high expression of miR-194-5p in human pancreatic cancer patients is associated with a better survival rate, while increased expression of programmed cell death ligand 1 in human pancreatic cancer patients is associated with a worse survival rate.
[International Immunopharmacology]
miR-194-5p down-regulates tumor cell PD-L1 expression and promotes anti-tumor immunity in pancreatic cancer. (2021). International Immunopharmacology, 97, 107822. https://doi.org/10.1016/j.intimp.2021.107822 Cite
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Tumor Suppressive Role of miR-33a-5p in Pancreatic Ductal Adenocarcinoma Cells by Directly Targeting RAP2A

Researchers observed for the first time that miR-33a-5p expression level was significantly decreased in pancreatic ductal adenocarcinoma tissues and cell lines.
[Cellular & Molecular Biology Letters]
Lian, Y., Jiang, D., & Sun, J. (2021). Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A. Cellular & Molecular Biology Letters, 26(1), 24. https://doi.org/10.1186/s11658-021-00265-w Cite
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Early Detection of Pancreatic Cancer Using DNA-Based Molecular Approaches

Investigators discuss and focus on the pathological and molecular features of precancerous lesions of the pancreas, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, which are target lesions of early detection approaches.
[Nature Reviews Gastroenterology & Hepatology]
Singhi, A. D., & Wood, L. D. (2021). Early detection of pancreatic cancer using DNA-based molecular approaches. Nature Reviews Gastroenterology & Hepatology, 1–12. https://doi.org/10.1038/s41575-021-00470-0 Cite
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The Pancreatic Cancer Genome Revisited

Given the vast developments within this field, scientists review the wide-ranging and most current information related to pancreatic cancer genomics with the goal of integrating this information into a unifying description of the life history of pancreatic cancer.
[Nature Reviews Gastroenterology & Hepatology]
Hayashi, A., Hong, J., & Iacobuzio-Donahue, C. A. (2021). The pancreatic cancer genome revisited. Nature Reviews Gastroenterology & Hepatology, 1–13. https://doi.org/10.1038/s41575-021-00463-z Cite
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Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models

Three paired pancreatic ductal adenocarcinoma preclinical models-patient-derived xenografts , xenograft-derived pancreatic organoids and xenograft-derived primary cell cultures-were derived from 20 patients and analyzed at the transcriptomic and chemosensitivity level.
[Cancers]
Hoare, O., Fraunhoffer, N., Elkaoutari, A., Gayet, O., Bigonnet, M., Roques, J., Nicolle, R., McGuckin, C., Forraz, N., Sohier, E., Tonon, L., Wajda, P., Boyault, S., Attignon, V., Tabone-Eglinger, S., Barbier, S., Mignard, C., Duchamp, O., Iovanna, J., & Dusetti, N. J. (2021). Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models. Cancers, 13(10), 2473. https://doi.org/10.3390/cancers13102473 Cite
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DayTwo, a Leader in Precision Medicine with the World’s Largest Microbiome Discovery Platform, Announces New Behavioral Science Approach for Diabetes Care

DayTwo, Inc. announced that it has launched a unique methodology for addressing depression in people with diabetes. The new solution, called EATS uses psychological techniques to overcome emotional barriers to chronic condition management.
[DayTwo, Inc. (Business Wire, Inc.)]
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Glucose Treatment of Human Pancreatic β-Cells Enhances Translation of mRNAs Involved in Energetics and Insulin Secretion

Reserachers described and validated the use of the SUnSET approach to demonstrate through FACS and Western Blot that glucose increases protein translation in the human cell line EndoC-βH2
[Journal of Biological Chemistry]
Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion. (2021). Journal of Biological Chemistry, 100839. https://doi.org/10.1016/j.jbc.2021.100839 Cite
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GRK2 Contributes to Glucose Mediated Calcium Responses and Insulin Secretion in Pancreatic Islet Cells

Utilizing Min6 cells, a pancreatic ß-cell model, scientists knocked down G-protein coupled receptor kinase 2 (GRK2) and measured glucose-mediated intracellular calcium responses and insulin secretion.
[Scientific Reports]
Snyder, J., Lackey, A. I., Brown, G. S., Diaz, M., Yuzhen, T., & Sato, P. Y. (2021). GRK2 contributes to glucose mediated calcium responses and insulin secretion in pancreatic islet cells. Scientific Reports, 11(1), 11129. https://doi.org/10.1038/s41598-021-90253-z Cite
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Pronounced Proliferation of Non-Beta Cells in Response to Beta-Cell Mitogens in Isolated Human Islets of Langerhans

Islets were kept intact or dispersed into single cells and cultured in the presence of harmine, glucose, or heparin-binding epidermal growth factor-like growth factor (HB-EGF), and subsequently analyzed by immunohistochemistry or flow cytometry.
[Scientific Reports]
Maachi, H., Ghislain, J., Tremblay, C., & Poitout, V. (2021). Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans. Scientific Reports, 11(1), 11283. https://doi.org/10.1038/s41598-021-90643-3 Cite
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In Vitro Assessment of a Synergistic Combination of Gemcitabine and Zebularine in Pancreatic Cancer Cells

Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
In vitro assessment of a synergistic combination of Gemcitabine and Zebularine in pancreatic cancer cells. (2021). Experimental Cell Research, 112660. https://doi.org/10.1016/j.yexcr.2021.112660 Cite
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