vTv Therapeutics Announces Positive Results from Mechanistic Study Indicating No Increased Risk of Ketoacidosis with TTP399 during Acute Insulin Withdrawal in Patients with Type 1 Diabetes

vTv Therapeutics, Inc. a clinical-stage biopharmaceutical company focused on the development of orally administered treatments for type 1 diabetes and psoriasis, announced positive results of a mechanistic study of TTP399 in patients with type 1 diabetes.
[vTv Therapeutics, Inc.]
[zotpress userid=” items=’ARAWWK92′ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Hansoh Pharma and OliX Pharmaceuticals Enter into Licensing and Collaboration Agreement to Develop and Commercialize siRNA Therapeutics in Greater China

Hansoh Pharmaceutical Group Co, Ltd and OliX Pharmaceuticals, Inc. announced a licensing and collaboration agreement to discover, develop and commercialize siRNA therapeutics in key targeted indications in Greater China, which includes mainland China, Taiwan, Hong Kong and Macau.
[Hansoh Pharmaceutical Group Co, Ltd (GlobeNewswire, Inc.)]
[zotpress userid=” items=’ARAWWK92′ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Sex-Biased Islet β Cell Dysfunction Is Caused by the MODY MAFA S64F Variant by Inducing Premature Aging and Senescence in Males

MAFAS64F production in male human β cells accelerated cellular senescence and increase senescence-associated secretory proteins compared to cells expressing MAFAWT.
[Cell Reports]
[zotpress userid=” items=’ARAWWK92′ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Spatially Confined Sub-Tumor Microenvironments in Pancreatic Cancer

Investigators deconvoluted the human pancreatic tumor microenvironment through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models.
[Cell]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Propofol Mediates Pancreatic Cancer Cell Activity through the Repression of ADAM8 via SP1

Researchers focused upon the effect of propofol on pancreatic cancer cells and the mechanism by which propofol reduced A disintegrin and metalloproteinase 8 (ADAM8) expression.
[Oncology Reports]
[zotpress userid=” items=’ARAWWK92′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

SETD8 Induces Stemness and Epithelial–Mesenchymal Transition of Pancreatic Cancer Cells by Regulating ROR1 Expression

SETD8 mediated receptor tyrosine kinase-like orphan receptor 1 (ROR1) activity and regulated pancreatic cancer cells invasion and migration, although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.
[Acta Biochimica Et Biophysica Sinica]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Single-Cell Analysis of Patient-Derived PDAC Organoids Reveals Cell State Heterogeneity and a Conserved Developmental Hierarchy

Researchers derived pancreatic ductal adenocarcinoma organoids from 18 primary tumors and two matched liver metastases, and showed that ‘classical’ and ‘basal-like’ cells coexist in individual organoids.
[Nature Communications]
[zotpress userid=” items=’ARAWWK81′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Intravital Imaging Technology Guides FAK-Mediated Priming in Pancreatic Cancer Precision Medicine according to Merlin Status

Scientists visualized transient manipulation of focal adhesion kinase, which integrated bidirectional cell-environment signaling, using intravital fluorescence lifetime imaging microscopy of the FAK-based Förster resonance energy transfer biosensor in mouse and patient-derived pancreatic ductal adenocarcinoma models.
[Science Advances]
[zotpress userid=” items=’ARAWWK82′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Cholesterol Biosynthesis Inhibitor RO 48–8071 Inhibits Pancreatic Ductal Adenocarcinoma Cell Viability by Deactivating the JNK and ERK/MAPK Signaling Pathway

RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.
[Molecular Medicine Reports]
[zotpress userid=” items=’ARAWWK83′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Multifunctional Thiosemicarbazones Targeting Sigma Receptors: In Vitro and In Vivo Antitumor Activities in Pancreatic Cancer Models

Researchers developed a novel sigma-2 receptor targeting thiosemicarbazone that incorporated a moiety associated with lysosome destabilization and ROS increase in order to design more efficient antitumor agent
[Cellular Oncology]
[zotpress userid=” items=’ARAWWK84′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

A20 Controls Expression of Beta-Cell Regulatory Genes and Transcription Factors

Scientists investigated the mechanisms underlying the protective role of A20 in the pancreatic beta-cell. Investigators demonstrated a role for A20 in controling beta-cell integrity and survival, which likely resulted from the regulation of inflammatory signaling
[Journal of Molecular Endocrinology]
[zotpress userid=” items=’ARAWWK85′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share