The authors suggest the observed therapeutic effect of lentiviral vector carrying VIP gene was due to the repression of diabetes-induced inflammation, its insulinotropic properties, and VIP-induced beta-cell proliferation.
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Erendor, F., Sahin, E. O., Sanlioglu, A. D., Balci, M. K., Griffith, T. S., & Sanlioglu, S. (2020). Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation. Gene Therapy, 1–12. https://doi.org/10.1038/s41434-020-0183-3 Cite
Researchers evaluated the potential beneficial effects of DGAT1 inhibitors on pancreatic β-cells, and further verified their antidiabetic effects in db/db mice.
[Acta Pharmacologica Sinica]
QKI-7 is highly expressed in human coronary arterial endothelial cells from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputation.
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Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M. V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F. L., Lois, N., Stitt, A. W., Grieve, D. J., & Margariti, A. (2020). Targeting QKI-7 in vivo restores endothelial cell function in diabetes. Nature Communications, 11(1), 3812. https://doi.org/10.1038/s41467-020-17468-y Cite
Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
Investigators indicated that radiofrequency ablation (RFA) treatment induced remodeling of tumor immune microenvironment in distant non-RFA tumors in pancreatic cancer mouse model.
[Cell Death & Disease]
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Fei, Q., Pan, Y., Lin, W., Zhou, Y., Yu, X., Hou, Z., Yu, X., Lin, X., Lin, R., Lu, F., Guan, H., & Huang, H. (2020). High-dimensional single-cell analysis delineates radiofrequency ablation induced immune microenvironmental remodeling in pancreatic cancer. Cell Death & Disease, 11(7), 1–13. https://doi.org/10.1038/s41419-020-02787-1 Cite
Using a genome-scale CRISPR screen in a mouse model for type 1 diabetes (T1D), researchers showed that deleting RNLS, a genome-wide association study candidate gene for T1D, made beta cells resistant to autoimmune killing.
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Cai, E. P., Ishikawa, Y., Zhang, W., Leite, N. C., Li, J., Hou, S., Kiaf, B., Hollister-Lock, J., Yilmaz, N. K., Schiffer, C. A., Melton, D. A., Kissler, S., & Yi, P. (2020). Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nature Metabolism, 1–12. https://doi.org/10.1038/s42255-020-0254-1 Cite
In rat cells and in mouse and human islets, SRI-37330 inhibited expression and signaling of thioredoxin-interacting protein, previously found to be elevated in diabetes and to have detrimental effects on islet function.
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Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action: Cell Metabolism. (n.d.). Retrieved July 28, 2020, from https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30360-0 Cite
Scientists generated a novel Kuma mutant mice with p.Q104del in the Insulin2 gene in a BRJ background that exhibited a severe immune deficiency.
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Researchers used pancreatic cancer cell lines (BxPC-3, Panc-1, and HPAF II) to examine the efficacy of iron chelator deferasirox in preventing invasion in vitro, evaluated using scratch assays and Boyden chamber assays.
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Investigators demonstrated that circRHOT1 was overexpressed in pancreatic cancer tissues and cell lines, and it was found to directly bind to miR‐125a‐3p, acting as an endogenous sponge to inhibit its activity.
[Journal of Cellular and Molecular Medicine]
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Ling, S., He, Y., Li, X., Hu, M., Ma, Y., Li, Y., Lu, Z., Shen, S., Kong, B., Zou, X., Jiang, K., & Huang, P. (n.d.). CircRHOT1 mediated cell proliferation, apoptosis and invasion of pancreatic cancer cells by sponging miR-125a-3p. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15572 Cite
Merus N.V. has announced that the US FDA has granted Orphan Drug Designation to Zenocutuzumab for the treatment of patients with pancreatic cancer.
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The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.