Locoregional Treatment of Metastatic Pancreatic Cancer Utilizing Resection, Ablation and Embolization: A Systematic Review

Investigators explore and evaluate the current evidence on locoregional treatments for metastatic PDAC.
[Cancers]
Timmer, F. E. F., Geboers, B., Nieuwenhuizen, S., Schouten, E. A. C., Dijkstra, M., de Vries, J. J. J., van den Tol, M. P., Meijerink, M. R., & Scheffer, H. J. (2021). Locoregional Treatment of Metastatic Pancreatic Cancer Utilizing Resection, Ablation and Embolization: A Systematic Review. Cancers, 13(7), 1608. https://doi.org/10.3390/cancers13071608 Cite
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The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus

The authors discuss the current knowledge of how metformin modulates type 2 diabetes mellitus (T2DM) with respect to the gut microbiome and discuss the prospect of harnessing this mechanism in treating T2DM.
[International Journal of Molecular Sciences]
Lee, C. B., Chae, S. U., Jo, S. J., Jerng, U. M., & Bae, S. K. (2021). The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus. International Journal of Molecular Sciences, 22(7), 3566. https://doi.org/10.3390/ijms22073566 Cite
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Celon Pharma Announces CPL’280, Second Generation Oral GPR40 Agonist, Meets Primary Endpoint in Phase I Trial

Celon Pharma S.A. announced the successful completion of a Phase I trial of its second generation GPR40 agonist, CPL’280. This agent is in development for the treatment of Diabetes and Diabetic Neuropathy and met its primary endpoint, with no adverse safety signals detected.
[Celon Pharma S.A. (Globe Newswire, Inc)]
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Insulin and Insulin Analogs as Antidiabetic Therapy: A Perspective from Clinical Trials

The authors discuss the development of the most widely available insulin preparations and provide evidence-based insight into their use in clinical practice.
[Cell Metabolism]
Kramer, C. K., Retnakaran, R., & Zinman, B. (2021). Insulin and insulin analogs as antidiabetic therapy: A perspective from clinical trials. Cell Metabolism, 33(4), 740–747. https://doi.org/10.1016/j.cmet.2021.03.014 Cite
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The Many Actions of Insulin in Skeletal Muscle, the Paramount Tissue Determining Glycemia

Scientists discuss the discoveries that have led to the current understanding of how insulin promotes glucose uptake in muscle.
[Cell Metabolism]
Sylow, L., Tokarz, V. L., Richter, E. A., & Klip, A. (2021). The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia. Cell Metabolism, 33(4), 758–780. https://doi.org/10.1016/j.cmet.2021.03.020 Cite
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Human Pluripotent Stem Cell-Derived Insulin-Producing Cells: A Regenerative Medicine Perspective

Investigators discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
[Cell Metabolism]
Migliorini, A., Nostro, M. C., & Sneddon, J. B. (2021). Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective. Cell Metabolism, 33(4), 721–731. https://doi.org/10.1016/j.cmet.2021.03.021 Cite
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Single-Cell Chromatin Accessibility Identifies Pancreatic Islet Cell Type-and State-Specific Regulatory Programs of Diabetes Risk

Researchers observed state-specific enrichment of fasting glucose and type 2 diabetes genome-wide association studies for beta cells and enrichment for other endocrine cell types.
[Nature Genetics]
Chiou, J., Zeng, C., Cheng, Z., Han, J. Y., Schlichting, M., Miller, M., Mendez, R., Huang, S., Wang, J., Sui, Y., Deogaygay, A., Okino, M.-L., Qiu, Y., Sun, Y., Kudtarkar, P., Fang, R., Preissl, S., Sander, M., Gorkin, D. U., & Gaulton, K. J. (2021). Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk. Nature Genetics, 1–12. https://doi.org/10.1038/s41588-021-00823-0 Cite
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MIB1 Upregulates IQGAP1 and Promotes Pancreatic Cancer Progression by Inducing ST7 Degradation

Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
[Molecular Oncology]
Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite
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LncRNA FGD5-AS1 Accelerates Cell Proliferation in Pancreatic Cancer by Regulating miR-520a-3p/KIAA1522 Axis

FGD5-AS1 accelerated cell proliferation and migration via sponging miR-520a-3p and upregulating KIAA1522.
[Cancer Biology & Therapy]
Lin, J., Liao, S., Liu, Z., Li, E., Wu, X., & Zeng, W. (2021). LncRNA FGD5-AS1 accelerates cell proliferation in pancreatic cancer by regulating miR-520a-3p/KIAA1522 axis. Cancer Biology & Therapy, 0(0), 1–10. https://doi.org/10.1080/15384047.2021.1883184 Cite
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AXL is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer

The authors used single cell RNA sequencing to reveal that AXL was expressed highly in tumor cells that had a mesenchymal-like phenotype and that AXL expression correlated with classic markers of epithelial to mesenchymal transition.
[Molecular Cancer Research]
Du, W., Phinney, N. Z., Huang, H., Wang, Z., Westcott, J., Toombs, J. E., Zhang, Y., Beg, M. S., Wilkie, T. M., Lorens, J. B., & Brekken, R. A. (2021). AXL is a key factor for cell plasticity and promotes metastasis in pancreatic cancer. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0860 Cite
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BCL3 Couples Cancer Stem Cell Enrichment with Pancreatic Cancer Molecular Subtypes

Scientists demonstrated that Bcl3 impacted pancreatic carcinogenesis by restraining cancer stem cell expansion and by curtailing an aggressive and metastatic tumor burden in pancreatic ductal adenocarcinoma across species.
[Gastroenterology]
Ai, J., Wörmann, S. M., Görgülü, K., Vallespinos, M., Zagorac, S., Alcala, S., Wu, N., Kabacaoglu, D., Berninger, A., Navarro, D., Kaya-Aksoy, E., Ruess, D. A., Ciecielski, K. J., Kowalska, M., Demir, E. I., Ceyhan, G. O., Heid, I., Braren, R., Riemann, M., … Algül, H. (2021). BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2021.03.051 Cite
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