Overexpression of Gjb4 Impairs Cell Proliferation and Insulin Secretion in Primary Islet Cells

Overexpression of gap junction beta 4 protein in primary islet cells significantly inhibited the proliferation by 47%, reduced insulin secretion of primary islets (46%) and INS-1 cells (51%) and enhanced the rate of apoptosis by 63% in INS-1 cells.
[Molecular Metabolism]

Sorry, but the selected Zotpress account can't be found.

AbstractFull Article
Bookmark

No account yet? Register

+1
Share

Identification of a Novel IL-5 Signaling Pathway in Chronic Pancreatitis and Crosstalk with Pancreatic Tumor Cells

The expression of IL-5R and the effects of IL-5 were analyzed in human and murine tumor cells.
[Cell Communication and Signaling]
Full Article
Bookmark

No account yet? Register

0
Share

GABA Stimulates β-Cell Proliferation through the mTORC1/p70S6K Pathway, an Effect Amplified by Ly49, a Novel GABAA-R Positive Allosteric Modulator

Researchers demonstrated that GABA stimulates β‐cell proliferation via the PI3K/mTORC1/p70S6K pathway in both mouse and human islets.
[Diabetes Obesity & Metabolism]

Sorry, but the selected Zotpress account can't be found.

Abstract
Bookmark

No account yet? Register

0
Share

Multiplexing DNA Methylation Markers to Detect Circulating Cell-Free DNA Derived from Human Pancreatic Beta-Cells

Scientists describe an ultrasensitive assay for detection of a β-cell-specific DNA methylation signature, by simultaneous assessment of six DNA methylation markers, that identified β-cell DNA in mixtures containing as little as 0.03% β-cell DNA (less than one β-cell genome equivalent).
[JCI Insight]
AbstractFull Article
Bookmark

No account yet? Register

0
Share

VentX Expression in Tumor Associated Macrophages Promotes Phagocytosis and Immunity against Pancreatic Cancers

Investigators found that the expression of homeobox protein VentX, a master regulator of macrophage plasticity, is significantly decreased in the ancreatic ductal adenocarcinoma (PDA)-tumor associated macrophages (TAMs). They demonstrated that VentX was required for phagocytosis and that restoration of VentX expression in PDA-TAMs promoted phagocytosis through regulating the signaling cascades involved in the process.
[JCI Insight]

Sorry, but the selected Zotpress account can't be found.

AbstractFull Article
Bookmark

No account yet? Register

0
Share

Insulin Receptor Endocytosis in the Pathophysiology of Insulin Resistance

The authors review the molecular mechanism of insulin receptor endocytosis and its impact on the pathophysiology of insulin resistance, and discuss the potential of Src homology phosphatase 2 as a therapeutic target for type 2 diabetes.
[Experimental and Molecular Medicine]
Full Article
Bookmark

No account yet? Register

0
Share

Corbus Pharmaceuticals Reports Last Subject Visit in Phase IIb Study of Lenabasum for Treatment of Cystic Fibrosis

Corbus Pharmaceuticals Holdings, Inc. announced that the last subject completed their final visit in the company’s Phase IIb JBT101-CF-002 trial of lenabasum for the treatment of cystic fibrosis.
[Corbus Pharmaceuticals Holdings, Inc]
Press Release
Bookmark

No account yet? Register

0
Share

Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
Press Release
Bookmark

No account yet? Register

0
Share

Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
Press Release
Bookmark

No account yet? Register

0
Share

Identification of a Periodontal Pathogen and Bihormonal Cells in Pancreatic Islets of Humans and a Mouse Model of Periodontitis

Investigators determined the specific localization of Porphyromonas gingivalis in relation to mouse and human pancreatic α- and β-cells using 3-D confocal and immunofluorescence microscopy and orthogonal analyses.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Scientists uncovered sequence-specific changes in RNA splicing enforced by mutant p53 which enhanced KRAS activity. Mutant p53 increased expression of splicing regulator hnRNPK to promote inclusion of cytosine-rich exons within GTPase-activating proteins, negative regulators of RAS family members.
[Cancer Cell]
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share
Share