Scientists determined to what extent fasting glycemic indices could estimate stimulated β‐cell function in islet transplant recipients with and without basal insulin.
[American Journal of Transplantation]
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Category Archives: Pancreatic Cell
Pancreatic Cell NewsPancreatic Cell News is an online publication and email newsletter providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Pancreatic Cell News is a weekly newsletter that highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
Fasting Parameters for Estimation of Stimulated β-Cell Function in Islet Transplant Recipients with or without Basal Insulin Treatment
MicroRNA-181c-5p Promotes the Formation of Insulin-Producing Cells from Human Induced Pluripotent Stem Cells by Targeting smad7 and TGIF2
Investigators differentiated human induced pluripotent stem cells into insulin-producing cells in a stepwise process that recapitulated pancreas organogenesis and observed that miR-181c-5p continuously accumulated throughout the entire differentiation process.
[Cell Death & Disease]
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NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T Cell Numbers
An Unbiased High‐Throughput Drug Screen Reveals a Potential Therapeutic Vulnerability in the Most Lethal Molecular Subtype of Pancreatic Cancer
In multiple in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDAC), spanning human and murine PDAC cells, and orthotopic xenografts, researchers determined that the expression of keratin 17 resulted in a more than two‐fold increase in resistance to Gem and 5‐fluorouracil, key components of current standard‐of‐care chemotherapeutic regimens.
[Molecular Oncology]
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Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways
Researchers showed glutathione S-transferase pi-1 knockdown reduced pancreatic ductal adenocarcinoma (PDAC) cell growth, prolonged the G0/G1 phase, and elevated reactive oxygen species in PDAC cells.
[Cancers]
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Plasma Interleukin-8 Is a Biomarker for TAK1 Activation and Predicts Resistance to Nanoliposomal Irinotecan in Patients with Gemcitabine-Refractory Pancreatic Cancer
In vivo activity of nanoliposomal irinotecan was validated in an orthotopic nude murine model expressing TAK1-specific shRNA. Differential expression profiling revealed the gene coding for interleukin-8 as the most significantly downregulated in shTAK1 pancreatic cancer cell lines.
[Clinical Cancer Research]
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Seven Bridges and the Pancreatic Cancer Action Network Partner to Develop High-Quality, Actionable Cancer Data Platform
PharmaCyte Biotech Completes Final cGMP Audit of Manufacturing Facility for Pancreatic Cancer Clinical Trial Product
PharmaCyte Biotech, Inc. announced that cGMP Validation, the company’s cGMP consultant, has completed its post manufacturing audit of the manufacturing facility in Thailand and that the facility has successfully passed the audit.
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature
The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
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BAP1 Is a Haploinsufficient Tumor Suppressor Linking Chronic Pancreatitis to Pancreatic Cancer in Mice
Researchers found that heterozygous loss of histone H2A lysine 119 deubiquitinase BRCA1 Associated Protein-1 associates with a history of chronic pancreatitis and occurs in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.
[Nature Communications]
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Mir34a Constrains Pancreatic Carcinogenesis
Investigators showed that the accelerated phenotype is driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells.
[Scientific Reports]
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