Fasting Parameters for Estimation of Stimulated β-Cell Function in Islet Transplant Recipients with or without Basal Insulin Treatment

Scientists determined to what extent fasting glycemic indices could estimate stimulated β‐cell function in islet transplant recipients with and without basal insulin.
[American Journal of Transplantation]
[zotpress items='{1254621:CDZJHDBZ}’ style=’apa’ cite=’yes’]
Bookmark

No account yet? Register

Share

MicroRNA-181c-5p Promotes the Formation of Insulin-Producing Cells from Human Induced Pluripotent Stem Cells by Targeting smad7 and TGIF2

Investigators differentiated human induced pluripotent stem cells into insulin-producing cells in a stepwise process that recapitulated pancreas organogenesis and observed that miR-181c-5p continuously accumulated throughout the entire differentiation process.
[Cell Death & Disease]
[zotpress items='{1254621:W3A55E36}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T Cell Numbers

To directly assess the role of NKG2D in the pancreas, scientists generated NOD mice that expressed an NKG2D ligand in β-islet cells.
[Diabetes]
[zotpress items='{1254621:XZ7YSZDK}’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

An Unbiased High‐Throughput Drug Screen Reveals a Potential Therapeutic Vulnerability in the Most Lethal Molecular Subtype of Pancreatic Cancer

In multiple in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDAC), spanning human and murine PDAC cells, and orthotopic xenografts, researchers determined that the expression of keratin 17 resulted in a more than two‐fold increase in resistance to Gem and 5‐fluorouracil, key components of current standard‐of‐care chemotherapeutic regimens.
[Molecular Oncology]
[zotpress items='{1254621:2LFVAMRX}’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways

Researchers showed glutathione S-transferase pi-1 knockdown reduced pancreatic ductal adenocarcinoma (PDAC) cell growth, prolonged the G0/G1 phase, and elevated reactive oxygen species in PDAC cells.
[Cancers]
[zotpress items='{1254621:49ZKRAMV}’ style=’apa’ cite=’yes’]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Plasma Interleukin-8 Is a Biomarker for TAK1 Activation and Predicts Resistance to Nanoliposomal Irinotecan in Patients with Gemcitabine-Refractory Pancreatic Cancer

In vivo activity of nanoliposomal irinotecan was validated in an orthotopic nude murine model expressing TAK1-specific shRNA. Differential expression profiling revealed the gene coding for interleukin-8 as the most significantly downregulated in shTAK1 pancreatic cancer cell lines.
[Clinical Cancer Research]
[zotpress items='{1254621:42HSG9CX}’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

Seven Bridges and the Pancreatic Cancer Action Network Partner to Develop High-Quality, Actionable Cancer Data Platform

Seven Bridges announced that it has been selected by the Pancreatic Cancer Action Network to build a customized, integrated health data platform to accelerate pancreatic cancer research.
Abstract
Bookmark

No account yet? Register

Share

PharmaCyte Biotech Completes Final cGMP Audit of Manufacturing Facility for Pancreatic Cancer Clinical Trial Product

PharmaCyte Biotech, Inc. announced that cGMP Validation, the company’s cGMP consultant, has completed its post manufacturing audit of the manufacturing facility in Thailand and that the facility has successfully passed the audit.
Full Article
Bookmark

No account yet? Register

Share

Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
Editorial
Bookmark

No account yet? Register

Share

BAP1 Is a Haploinsufficient Tumor Suppressor Linking Chronic Pancreatitis to Pancreatic Cancer in Mice

Researchers found that heterozygous loss of histone H2A lysine 119 deubiquitinase BRCA1 Associated Protein-1 associates with a history of chronic pancreatitis and occurs in 25% of pancreatic ductal adenocarcinomas and 40% of acinar cell carcinomas.
[Nature Communications]
[zotpress items='{1254621:VLCSLFLD}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Mir34a Constrains Pancreatic Carcinogenesis

Investigators showed that the accelerated phenotype is driven by an early up-regulation of the pro-inflammatory cytokines TNFA and IL6 in normal acinar cells and accompanied by the recruitment of immune cells.
[Scientific Reports]
[zotpress items='{1254621:FY72ASEF}’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share