Prostate Carcinogenesis: Inflammatory Storms

Scientists provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.
[Nature Reviews Cancer]
de Bono, J. S., Guo, C., Gurel, B., De Marzo, A. M., Sfanos, K. S., Mani, R. S., Gil, J., Drake, C. G., & Alimonti, A. (2020). Prostate carcinogenesis: inflammatory storms. Nature Reviews Cancer, 1–15. https://doi.org/10.1038/s41568-020-0267-9 Cite
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Urupocidin C: A New Marine Guanidine Alkaloid which Selectively Kills Prostate Cancer Cells via Mitochondria Targeting

Researchers discovered a promising selectivity of both alkaloids for human prostate cancer cells, including highly drug-resistant lines, compared to non-malignant cells.
[Scientific Reports]
Dyshlovoy, S. A., Kudryashova, E. K., Kaune, M., Makarieva, T. N., Shubina, L. K., Busenbender, T., Denisenko, V. A., Popov, R. S., Hauschild, J., Fedorov, S. N., Bokemeyer, C., Graefen, M., Stonik, V. A., & von Amsberg, G. (2020). Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting. Scientific Reports, 10(1), 9764. https://doi.org/10.1038/s41598-020-66428-5 Cite
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AR and ERG Drive the Expression of Prostate Cancer Specific Long Noncoding RNAs

In vitro validations confirmed that androgen receptor and ETS-related gene (ERG) regulated a subset of TPCATs, most notably for EPCART.
[Oncogene]
Kohvakka, A., Sattari, M., Shcherban, A., Annala, M., Urbanucci, A., Kesseli, J., Tammela, T. L. J., Kivinummi, K., Latonen, L., Nykter, M., & Visakorpi, T. (2020). AR and ERG drive the expression of prostate cancer specific long noncoding RNAs. Oncogene, 1–11. https://doi.org/10.1038/s41388-020-1365-6 Cite
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KLF5 Inhibits STAT3 Activity and Tumor Metastasis in Prostate Cancer by Suppressing IGF1 Transcription Cooperatively with HDAC1

Scientists knocked down KLF5 in prostate cancer cells and found that KLF5 knockdown promoted invasive ability of prostate cancer cells in vitro and in vivo .
[Cell Death & Disease]
Ma, J.-B., Bai, J.-Y., Zhang, H.-B., Jia, J., Shi, Q., Yang, C., Wang, X., He, D., & Guo, P. (2020). KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1. Cell Death & Disease, 11(6), 1–14. https://doi.org/10.1038/s41419-020-2671-1 Cite
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Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo

The authors revealed that dehydrozingerone decreased cell proliferation of rat castration-resistant prostate cancer, PLS10 cells, via induction of the cell cycle arrest in the G1 phase in vitro.
[Molecules]
Mapoung, S., Suzuki, S., Fuji, S., Naiki-Ito, A., Kato, H., Yodkeeree, S., Sakorn, N., Ovatlarnporn, C., Takahashi, S., & Limtrakul (Dejkriengkraikul), P. (2020). Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo. Molecules, 25(12), 2737. https://doi.org/10.3390/molecules25122737 Cite
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Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells

Palmitic acid decreased the secretion of exosomes in human prostate cancer cells in vitro in a concentration-dependent manner.
[Molecules]
Maly, I. V., & Hofmann, W. A. (2020). Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells. Molecules (Basel, Switzerland), 25(12). https://doi.org/10.3390/molecules25122722 Cite
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Androgens Modify Therapeutic Response to Cabazitaxel in Models of Advanced Prostate Cancer

To examine the impact of androgens on the antitumor effect of cabazitaxel (CBZ), investigators used human prostate cancer cell lines with different sensitivity to androgens and CBZ.
[Prostate]
Begemann, D., Wang, Y., Yang, W., & Kyprianou, N. (n.d.). Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer. The Prostate, n/a(n/a). https://doi.org/10.1002/pros.24015 Cite
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Resveratrol Inhibits the Tumor Migration and Invasion by Upregulating TET1 and Reducing TIMP2/3 Methylation in Prostate Carcinoma Cells

Resveratrol inhibited the migration and invasion of prostate cancer cells, promoted the demethylation of tissue inhibitor of metalloproteinases (TIMP)2 and TIMP3 to upregulate their expressions, and suppressed the expressions of MMP2 and MMP9.
[Prostate]
Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells - Wang - - The Prostate - Wiley Online Library. (n.d.). Retrieved June 19, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.24029 Cite
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Altered Staining Patterns and Expression Level of Engrailed-2 in Benign Prostatic Hyperplasia and Prostate Cancer Predict Prostatic Disease Progression

Scientists showed that their homemade engrailed-2 (EN2) monoclonal antibody could specifically bind endogenous and exogenous EN2 protein in three different prostate cancer cell lines.
[BMC Cancer]
Li, Q., Shi, Y., Sa, R., Hao, J., Hu, J., Xiao, M., Wang, C., Yan, L., Qiao, B., & Chen, G. (2020). Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression. BMC Cancer, 20(1), 555. https://doi.org/10.1186/s12885-020-07049-z Cite
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Novel Long Non-Coding RNA lncAMPC Promotes Metastasis and Immunosuppression in Prostate Cancer by Stimulating LIF/LIFR Expression

The biological capacity of lncRNA named lncRNA activated in metastatic PCa (lncAMPC) in prostate cancer (PCa) was demonstrated both in vitro and in vivo. The lncAMPC was overexpressed in tumor tissue and urine of metastatic PCa patients and promoted PCa tumorigenesis and metastasis.
[Molecular Therapy]
Zhang, W., Shi, X., Chen, R., Zhu, Y., Peng, S., Chang, Y., … Ren, S. (2020). Novel long non-coding RNA lncAMPC promotes metastasis and immunosuppression in prostate cancer by stimulating LIF/LIFR expression. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.06.013 Cite
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Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.
[ScienceInsider]
Editorial

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