LINC00992 Exerts Oncogenic Activities in Prostate Cancer via Regulation of SOX4

LNC992 elevated SOX4 expression by binding to SOX4 mRNA and recruiting translation initiation factor EIF4A3, thereby promoting the growth and metastasis of prostate cancer cells in vitro and in vivo.
[Experimental Cell Research]
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Discovery of a New Candidate Drug to Overcome Cabazitaxel-Resistant Gene Signature in Castration-Resistant Prostate Cancer by In Silico Screening

Researchers used screening tests for candidate drugs targeting cabazitaxel (CBZ)-resistant-related gene expression and identified pimozide as a potential candidate for overcoming CBZ resistance in castration-resistant prostate cancer.
[Prostate Cancer and Prostatic Diseases]
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Regulatory Mechanism of Androgen Receptor on NCAPD3 Gene Expression in Prostate Cancer

NCAPD3 is an androgen/AR axis-targeted gene and is involved in androgen receptor (AR)-induced prostate cancer (PCa) cell proliferation, migration, and invasion in vitro and in vivo. Androgen treatment and AR overexpression increased the expression of NCAPD3 in PCa cell lines.
[Prostate]
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Comparison of Low-Molecular-Weight Ligand and Whole Antibody in Prostate-Specific Membrane Antigen Targeted Near-Infrared Photoimmunotherapy

Scientists investigated differences in cytotoxicity and mechanisms between LMW-IR700 and Ab-IR700 targeting prostate-specific membrane antigen.
[International Journal of Pharmaceutics]
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Synthesis and Biological Evaluation of 1,2, 3-Triazole Hybrids of 4-Methoxy Ethyl Cinnamate Isolated from Hedychium spicatum (Sm) Rhizomes: Identification of Antiproliferative Lead Actives against Prostate Cancer

Among the compounds tested, compounds 9i and 9k potently arrested proliferation of DU-145, the prostate cancer cell line.
[Natural Product Research]
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Curcumol Inhibits the Malignant Progression of Prostate Cancer and Regulates the PDK1/AKT/mTOR Pathway by Targeting miR-9

Researchers analyzed the effect of curcumol on prostate cancer and identify its possible internal regulatory pathway using in vitro cell culture and in vivo tumor model experiments.
[Oncology Reports]
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Inhibition of CDK9 Activity Compromises Global Splicing in Prostate Cancer Cells

The authors showed that CDK9 inhibition resulted in the loss of androgen receptor (AR) and AR-v7 expression due to the defects in splicing, which sensitized castration-resistant prostate cancer cells to androgen deprivation.
[RNA Biology]
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Extracellular Vesicles and Immunogenic Stress in Cancer

The authors discuss the current understanding of the immunogenic stress pathways in cancer and describes the interrelation between extracellular vesicles and immunogenic stress to propose potential treatment strategies and biomarkers.
[Cell Death & Disease]
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Patient Derived Organoids in Prostate Cancer: Improving Therapeutic Efficacy in Precision Medicine

Scientists evaluate the advances in 3D culture and patient derived organoid (PDO) use to model clonal heterogeneity and screen for effective targeted therapies, with a focus on the technological advances in generating PDOs.
[Molecular Cancer]
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Bergamottin a CYP3A Inhibitor Found in Grapefruit Juice Inhibits Prostate Cancer Cell Growth by Downregulating Androgen Receptor Signaling and Promoting G0/G1 Cell Cycle Block and Apoptosis

Researchers observed that bergamottin reduced prostate cancer cell growth by decreasing both total and nuclear AR reducing downstream AR signaling.
[PLOS One]
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Cancer Cells with Defective RB and CDKN2A Are Resistant to the Apoptotic Effects of Rapamycin

Scientists observed that DU145 prostate and NCI–H2228 lung cancer cells were resistant to the cytotoxic effect of rapamycin.
[Cancer Letters]
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