Inhibition of EZH2 Transactivation Function Sensitizes Solid Tumors to Genotoxic Stress

Investigators showed that EZH2 inhibitors could block the transactivation activity of EZH2 and inhibit the growth of CRPC cells, which revealed a previously unappreciated mechanism of action of EZH2 inhibitors and provided a mechanistic basis for potential combination cancer therapies.
[Proceedings of the National Academy of Sciences of the United States of America]
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Prostate Cancer Cell Proliferation Is Influenced by LDL-Cholesterol Availability and Cholesteryl Ester Turnover

As cholesterol is a key substrate for de novo steroidogenesis in prostate cells, researchers hypothesized that castrate-resistant/advanced prostate cancer cell growth was influenced by the availability of extracellular, low-density lipoprotein (LDL)-derived, cholesterol, which was coupled to intracellular cholesteryl ester homeostasis.
[Cancer & Metabolism]
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Prostate Cancer Immunotherapy

The authors present completed and ongoing research projects regarding prostate cancer immunotherapy. Ipilimumab and olaparib were proved to prolong overall survival significantly against placebo, but a lot of research is going on to identify which patients and at what stage of disease will benefit the most before incorporating them in clinical practice.
[Expert Opinion On Biological Therapy]
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ETS Factors in Prostate Cancer

Scientists summarize the data on the discovery, modeling, molecular taxonomy, lineage plasticity and therapeutic targeting of ETS family members in prostate cancer.
[Cancer Letters]
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23andMe Receives FDA Clearance for Direct-to-Consumer Genetic Test on a Hereditary Prostate Cancer Marker

23andMe Holding Co. received FDA clearance for a genetic health risk report on a hereditary prostate cancer marker.
[23andMe Holding Co.]
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Single-Cell Analysis of Human Primary Prostate Cancer Reveals the Heterogeneity of Tumor-Associated Epithelial Cell States

Researchers uncovered heterogeneous cellular states in prostate epithelial cells marked by high androgen signaling states that were enriched in prostate cancer and identified a population of tumor-associated club cells that may be associated with prostate carcinogenesis.
[Nature Communications]
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Overcoming Resistance to Immune Checkpoint Therapy in PTEN-Null Prostate Cancer by Intermittent Anti-PI3Kα/β/δ Treatment

Scientists found that intermittent but not daily dosing of a PI3Kα/β/δ inhibitor, BAY1082439, on Pten-null prostate cancer models could overcome immune checkpoint therapy resistance and unleash CD8+ T cell-dependent anti-tumor immunity in vivo.
[Nature Communications]
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MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells

The authors demonstrated that MUC1-C drove global changes in chromatin architecture in the dedifferentiation of CRPC and triple-negative breast cancer cells.
[Molecular Cancer Research]
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Targeting Protein Arginine Methyltransferase 5 (PRMT5) Suppresses Radiation-Induced Neuroendocrine Differentiation and Sensitizes Prostate Cancer Cells to Radiation

Scientists performed transcriptomic analysis and confirmed that fractionated ionizing radiation (FIR)-induced neuroendocrine (NE)-like cells share some features of clinical NE prostate cancer, suggesting that FIR-induced NE differentiation represents a clinically-relevant model.
[Molecular Cancer therapeutics]
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Combined Effect of Heat Shock Protein Inhibitor Geldanamycin and Free Radicals on Photodynamic Therapy of Prostate Cancer

The authors found that the inhibition of Hsp90 could inhibit the overexpression of its client proteins such as anti-apoptotic proteins and androgen receptor, thereby improving the efficacy of photodynamic therapy and inducing prostate cancer cell apoptosis.
[Journal of Materials Chemistry B]
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Acquired Resistance to Irradiation or Docetaxel Is Not Associated with Cross-Resistance to Cisplatin in Prostate Cancer Cell Lines

Researchers investigated whether acquired resistance against ionizing radiation or docetaxel chemotherapy—two commonly applied treatment modalities in prostate cancer—influences the cisplatin tolerance in metastatic CRPC cell line models.
[Journal of Cancer Research and Clinical Oncology]
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