Management of Prostate Cancer Patients during COVID-19 Pandemic

Prostate cancer patients’ management demands prioritization, adjustments, and a tailored approach during the unprecedented SARS-CoV-2 pandemic. Benefit of care from treatment must be carefully weighed against the potential of infection and morbidity from COVID-19.
[Prostate Cancer and Prostatic Diseases]
Management of prostate cancer patients during COVID-19 pandemic | Prostate Cancer and Prostatic Diseases. (n.d.). Retrieved July 22, 2020, from https://www.nature.com/articles/s41391-020-0258-7 Cite
Full Article

Continue reading “Management of Prostate Cancer Patients during COVID-19 Pandemic”

Bookmark

No account yet? Register

0
Share

Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
Press Release

Continue reading “Science Money Slashed in EU’s €1.8-Trillion Budget Deal”

Bookmark

No account yet? Register

0
Share

Pharmacologically Targetable Vulnerability in Prostate Cancer Carrying RB1-SUCLA2 Deletion

Researchers found a significant metabolic shift in SUCLA2-deleted prostate cancer cells, including lower mitochondrial respiratory activity.
[Oncogene]
Kohno, S., Linn, P., Nagatani, N., Watanabe, Y., Kumar, S., Soga, T., & Takahashi, C. (2020). Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. Oncogene, 1–18. https://doi.org/10.1038/s41388-020-1381-6 Cite
Abstract

Continue reading “Pharmacologically Targetable Vulnerability in Prostate Cancer Carrying RB1-SUCLA2 Deletion”

Bookmark

No account yet? Register

0
Share

BRD4 Regulates Key Transcription Factors That Drive Epithelial–Mesenchymal Transition in Castration-Resistant Prostate Cancer

Using prostate cancer cell lines with different androgen receptor composition, the authors systematically manipulated somatic proteins of the Bromodomain and ExtraTerminal (BET) family to determine which BET proteins influence EMT.
[Prostate Cancer and Prostatic Diseases]
Shafran, J. S., Jafari, N., Casey, A. N., Győrffy, B., & Denis, G. V. (2020). BRD4 regulates key transcription factors that drive epithelial–mesenchymal transition in castration-resistant prostate cancer. Prostate Cancer and Prostatic Diseases, 1–10. https://doi.org/10.1038/s41391-020-0246-y Cite
Abstract

Continue reading “BRD4 Regulates Key Transcription Factors That Drive Epithelial–Mesenchymal Transition in Castration-Resistant Prostate Cancer”

Bookmark

No account yet? Register

0
Share

The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond

Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News]
Press Release

Continue reading “The Career Cost of COVID-19 to Female Researchers, and How Science Should Respond”

Bookmark

No account yet? Register

0
Share

Analysis of the Expression and Association of Retinoblastoma Binding Protein 6 (RBBP6) with the JNK Signaling Pathway in Prostate Cancers

PC3 and DU145 cells were transfected with RBBP6 siRNAs to examine the biological characteristics. Anisomycin with/without RBBP6 siRNA was used to treat PC3 cells for further investigating the ramification of the RBBP6‐mediated JNK pathway in prostate cancer.
[Cell Biology International]
Guan, W.-Y., Zhao, S., & Luo, Y.-N. (n.d.). Analysis of the expression and association of retinoblastoma binding protein 6 (RBBP6) with the JNK signaling pathway in prostate cancers. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11419 Cite
Abstract

Continue reading “Analysis of the Expression and Association of Retinoblastoma Binding Protein 6 (RBBP6) with the JNK Signaling Pathway in Prostate Cancers”

Bookmark

No account yet? Register

0
Share

Pyruvate-Lactate Exchange and Glucose Uptake in Human Prostate Cancer Cell Models. A Study in Xenografts and Suspensions by Hyperpolarized [113C]pyruvate MRS and [18F]FDG-PET

Scientists compared murine xenografts of human prostate cancer LNCaP cells with those of more aggressive PC3 cells.
[Nmr in Biomedicine]
Heijster, F. H. A. van, Heskamp, S., Breukels, V., Veltien, A., Franssen, G. M., Jansen, K. (C) F. J., Boerman, O. C., Schalken, J. A., Scheenen, T. W. J., & Heerschap, A. (n.d.). Pyruvate-lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1-13C]pyruvate MRS and [18F]FDG-PET. NMR in Biomedicine, n/a(n/a), e4362. https://doi.org/10.1002/nbm.4362 Cite
Full Article

Continue reading “Pyruvate-Lactate Exchange and Glucose Uptake in Human Prostate Cancer Cell Models. A Study in Xenografts and Suspensions by Hyperpolarized [113C]pyruvate MRS and [18F]FDG-PET”

Bookmark

No account yet? Register

0
Share

EU Leaders Slash Science Spending in €1.8 Trillion Deal

Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[Science Insider]
Press Release

Continue reading “EU Leaders Slash Science Spending in €1.8 Trillion Deal”

Bookmark

No account yet? Register

0
Share

‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge

Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider]
Editorial

Continue reading “‘Ethically Troubling.’ University Reopening Plans Put Professors, Students on Edge”

Bookmark

No account yet? Register

0
Share

Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints

Amid concerns that the torrent of research papers on COVID-19 could be leading to an excess of sloppy work, a computer scientist who develops automated programs to spot duplicate images in research papers is running his software across the world’s coronavirus preprints. So far, his efforts have yielded mixed success and some controversy.
[Nature News]
Press Release

Continue reading “Pioneering Duplication Detector Trawls Thousands of Coronavirus Preprints”

Bookmark

No account yet? Register

0
Share

RedHill Biopharma Receives Approval for Phase II/III COVID-19 Study in Russia

RedHill Biopharma Ltd. announced approval from the Ministry of Health of the Russian Federation for its Clinical Trial Authorization application for a Phase II/III study evaluating opaganib in patients hospitalized with severe SARS-CoV-2 infection and pneumonia.
[RedHill Biopharma Ltd.]
Press Release

Continue reading “RedHill Biopharma Receives Approval for Phase II/III COVID-19 Study in Russia”

Bookmark

No account yet? Register

0
Share

A Rare Variant of African Ancestry Activates 8q24 lncRNA Hub by Modulating Cancer Associated Enhancer

The authors showed that the variant rs72725854 was present in a prostate cancer-specific enhancer at 8q24 locus.
[Nature Communications]
Walavalkar, K., Saravanan, B., Singh, A. K., Jayani, R. S., Nair, A., Farooq, U., Islam, Z., Soota, D., Mann, R., Shivaprasad, P. V., Freedman, M. L., Sabarinathan, R., Haiman, C. A., & Notani, D. (2020). A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer. Nature Communications, 11(1), 3598. https://doi.org/10.1038/s41467-020-17325-y Cite
Full Article

Continue reading “A Rare Variant of African Ancestry Activates 8q24 lncRNA Hub by Modulating Cancer Associated Enhancer”

Bookmark

No account yet? Register

0
Share
Share