Single-cell-based approaches revealed striking temporal changes to the transcriptome and chromatin accessibility which have identified the emergence of distinct cell populations, marked by differential expression of Ascl1 and Pou2f3, during the transition to neuroendocrine prostate cancer.
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Investigators found a total of 137 genes were ectopically expressed in eight cancer types, of which Holliday junction recognition protein (HJURP) was significantly upregulated in prostate cancer.
[Cell Death & Disease]
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Scientists explored the mechanism of action of Maytenus royleanus (MEM) in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of various signaling pathways and effected genes to define the mechanism of MEM action in Pca.
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The authors utilized the established non-malignant HPr1-AR prostate epithelial cell model that upon androgen exposure committed to a luminal cell differentiation trajectory from that of a basal-like state.
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Treatment of C4-2 cells with the 4F2 cell-surface antigen heavy chain was found to suppress cellular growth, migratory and invasive abilities, with this effect occurring through the cell cycle, with a significant decrease in S phase and a significant increase in G0/G1 phase, suggesting cell cycle arrest.
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Scientists showed that the molecular chaperone GRP75 is a key player in prostate cancer cells by maintaining the protein stability of SIX1, a transcription factor for embryonic development.
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Researchers found that depletion of either FKBP51 or FKBP52 reduced androgen receptor(AR) dimer formation, chromatin binding and phosphorylation, suggesting defective AR signaling.
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Anti-cancer activity of catechin nanoemulsions prepared from Oolong tea leaf waste was studied on prostate cancer cells DU-145 and DU-145-induced tumors in mice.
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Scientists found that chronic exposure to antimony promoted cell growth and lipid metabolic disequilibrium in prostate cancer.
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The authors designed a dissection method for validating the use of a 15-gene hypoxia classifier, which was previously established for head and neck squamous cell carcinoma patients, to identify hypoxia in prostate cancer.
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Investigators evaluated the inhibitory effects of resveratrol on cell proliferation associated with prostatic hyperplasia using WPMY-1 cells.
[International Journal of Molecular Sciences]
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