Investigators report that SUMOylation regulated the binding of hexokinase 2 to mitochondria. They found that hexokinase 2 could be SUMOylated at K315 and K492.
6807162 LM9AVKJ9 items 1 apa default asc 1
Shangguan, X., He, J., Ma, Z., Zhang, W., Ji, Y., Shen, K., Yue, Z., Li, W., Xin, Z., Zheng, Q., Cao, Y., Pan, J., Dong, B., Cheng, J., Wang, Q., & Xue, W. (2021). SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis. Nature Communications, 12(1), 1812. https://doi.org/10.1038/s41467-021-22163-7 Cite
The authors showed that Pin1 interacted with androgen receptor (AR) N-terminal domain. The inhibition of Pin1 expression or its activity selectively reduced the transcriptional activities of full-length AR and AR-V7.
6807162 ADDTJEGU items 1 apa default asc 1
Scientists demonstrated that enhancer of zeste homolog-2 (EZH2) inhibition in prostate cancer models activated a double-stranded RNA–STING–ISG stress response upregulating genes involved in antigen presentation, Th1 chemokine signaling and interferon response, including programmed cell death protein 1 (PD-L1) that was dependent on STING activation.
6807162 9PAWL2R3 items 1 apa default asc 1
Morel, K. L., Sheahan, A. V., Burkhart, D. L., Baca, S. C., Boufaied, N., Liu, Y., Qiu, X., Cañadas, I., Roehle, K., Heckler, M., Calagua, C., Ye, H., Pantelidou, C., Galbo, P., Panja, S., Mitrofanova, A., Wilkinson, S., Whitlock, N. C., Trostel, S. Y., … Ellis, L. (2021). EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer. Nature Cancer, 1–13. https://doi.org/10.1038/s43018-021-00185-w Cite
Researchers demonstrated that epithelial–mesenchymal transition in prostate tumors was promoted by obesity and suppressed upon pharmacological adipose stromal cells depletion in HiMyc mice, a spontaneous genetic model of prostate cancer.
[npj Precision Oncology]
6807162 RELJX6EW items 1 apa default asc 1
Su, F., Daquinag, A. C., Ahn, S., Saha, A., Dai, Y., Zhao, Z., DiGiovanni, J., & Kolonin, M. G. (2021). Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium. Npj Precision Oncology, 5(1), 1–10. https://doi.org/10.1038/s41698-021-00160-9 Cite
Investigators designed a novel computed-tomography (CT)–SPRT technique to deliver a single high-dose 25 Gy fraction of X-ray radiation.
6807162 EQHTHV73 items 1 apa default asc 1
Zahalka, A. H., Brodin, N. P., Maryanovich, M., Wang, X., Watts, K. L., Pinho, S., Guha, C., & Frenette, P. S. (2021). Using CT-guided stereotactic prostate radiation therapy (CT-SPRT) to assess sustained murine prostate ablation. Scientific Reports, 11(1), 6571. https://doi.org/10.1038/s41598-021-86067-8 Cite
Ongoing research to establish predictive biomarkers for the treatment of tumors with resistance to second-generation androgen receptor antagonists led to the approval of the PARP inhibitors olaparib and rucaparib in pre-treated metastatic castration-resistant prostate cancer.
[Nature Reviews Urology]
Scientists performed CRISPRi screens of 260 cis-regulatory elements (rCREs) in prostate cancer cell lines. They found that rCREs harboring high risk SNPs were more essential for cell proliferation and H3K27ac occupancy was a strong indicator of essentiality.
6807162 RJUTXYIZ items 1 apa default asc 1
Ahmed, M., Soares, F., Xia, J.-H., Yang, Y., Li, J., Guo, H., Su, P., Tian, Y., Lee, H. J., Wang, M., Akhtar, N., Houlahan, K. E., Bosch, A., Zhou, S., Mazrooei, P., Hua, J. T., Chen, S., Petricca, J., Zeng, Y., … He, H. H. (2021). CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Nature Communications, 12(1), 1781. https://doi.org/10.1038/s41467-021-21867-0 Cite
The authors investigated the effects of exogenous oxytocin on both stromal cell proliferation, and inherent spontaneous prostate contractions using primary models derived from human prostate tissue.
6807162 AFJTVYLA items 1 apa default asc 1
Oxytocin receptor antagonists as a novel pharmacological agent for reducing smooth muscle tone in the human prostate | Scientific Reports. (n.d.). Retrieved March 18, 2021, from https://www.nature.com/articles/s41598-021-85439-4 Cite
Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling.
6807162 G35EE5ZE items 1 apa default asc 1
Zhang, B., Li, Y., Wu, Q., Xie, L., Barwick, B., Fu, C., Li, X., Wu, D., Xia, S., Chen, J., Qian, W. P., Yang, L., Osunkoya, A. O., Boise, L., Vertino, P. M., Zhao, Y., Li, M., Chen, H.-R., Kowalski, J., … Dong, J.-T. (2021). Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nature Communications, 12(1), 1714. https://doi.org/10.1038/s41467-021-21976-w Cite
Researchers investigated the potential role of vinculin in prostate cancer progression in vitro and in vivo.
6807162 YMYTDL9M items 1 apa default asc 1
Zheng, X., Xu, H., Gong, L., Cao, D., Jin, T., Wang, Y., Pi, J., Yang, Y., Yi, X., Liao, D., Jin, X., Wei, Q., Yang, L., Li, H., & Ai, J. (n.d.). Vinculin orchestrates prostate cancer progression by regulating tumor cell invasion, migration, and proliferation. The Prostate, n/a(n/a). https://doi.org/https://doi.org/10.1002/pros.24113 Cite
The authors investigated the effect of β-arrestin 1 overexpression in prostate cancer development and progression using the mouse and human prostate cancer cell xenografts, and autochthonous transgenic adenocarcinoma mouse prostate models deficient in β-arrestins.
6807162 J6TCQLDV items 1 apa default asc 1