Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
The authors summarize clinical trials leading to recent drug approvals and discuss optimal treatment selection.
[Trends in Cancer]
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Bio-Techne Corporation announced that Exosome Diagnostics has established a new partnership with ZERO – The End of Prostate Cancer.
Scientists provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.
[Nature Reviews Cancer]
Researchers discovered a promising selectivity of both alkaloids for human prostate cancer cells, including highly drug-resistant lines, compared to non-malignant cells.
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Dyshlovoy, S. A., Kudryashova, E. K., Kaune, M., Makarieva, T. N., Shubina, L. K., Busenbender, T., Denisenko, V. A., Popov, R. S., Hauschild, J., Fedorov, S. N., Bokemeyer, C., Graefen, M., Stonik, V. A., & von Amsberg, G. (2020). Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting. Scientific Reports, 10(1), 9764. https://doi.org/10.1038/s41598-020-66428-5 Cite
In vitro validations confirmed that androgen receptor and ETS-related gene (ERG) regulated a subset of TPCATs, most notably for EPCART.
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Kohvakka, A., Sattari, M., Shcherban, A., Annala, M., Urbanucci, A., Kesseli, J., Tammela, T. L. J., Kivinummi, K., Latonen, L., Nykter, M., & Visakorpi, T. (2020). AR and ERG drive the expression of prostate cancer specific long noncoding RNAs. Oncogene, 1–11. https://doi.org/10.1038/s41388-020-1365-6 Cite
Scientists knocked down KLF5 in prostate cancer cells and found that KLF5 knockdown promoted invasive ability of prostate cancer cells in vitro and in vivo .
[Cell Death & Disease]
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Ma, J.-B., Bai, J.-Y., Zhang, H.-B., Jia, J., Shi, Q., Yang, C., Wang, X., He, D., & Guo, P. (2020). KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1. Cell Death & Disease, 11(6), 1–14. https://doi.org/10.1038/s41419-020-2671-1 Cite
The authors revealed that dehydrozingerone decreased cell proliferation of rat castration-resistant prostate cancer, PLS10 cells, via induction of the cell cycle arrest in the G1 phase in vitro.
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Mapoung, S., Suzuki, S., Fuji, S., Naiki-Ito, A., Kato, H., Yodkeeree, S., Sakorn, N., Ovatlarnporn, C., Takahashi, S., & Limtrakul (Dejkriengkraikul), P. (2020). Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo. Molecules, 25(12), 2737. https://doi.org/10.3390/molecules25122737 Cite
Palmitic acid decreased the secretion of exosomes in human prostate cancer cells in vitro in a concentration-dependent manner.