United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider]
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Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]
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Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]
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Inhibition of Notch Pathway Enhances the Anti-Tumor Effect of Docetaxel in Prostate Cancer Stem-Like Cells

The effect of Notch inhibition on response to DOX was evaluated in prostate cancer stem-like cells in vitro and in murine models using a γ-secretase inhibitor, PF-03084014.
[Stem Cell Research & Therapy]
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Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

The authors present an overview of the main cytokines/chemokines, including IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1, and CXCL16, that exert modulatory roles in prostate cancer metastasis.
[International Journal of Molecular Sciences]
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Promotion of Epithelial Hyperplasia by interleukin-8-CXCR Axis in Human Prostate

The expression of the IL‐8 axis components was confined to the prostate luminal epithelial cells in both normal and benign prostatic hyperplasia tissues.
[Prostate]
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Myovant Sciences Announces Priority Review and FDA Acceptance of New Drug Application for Once-Daily, Oral Relugolix for Advanced Prostate Cancer

Myovant Sciences announced that its New Drug Application for once-daily, oral relugolix for the treatment of men with advanced prostate cancer has been accepted for Priority Review by the FDA.
[Myovant Sciences]
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Androgen Receptor-Induced Integrin α6β1 and Bnip3 Promote Survival and Resistance to PI3K Inhibitors in Castration-Resistant Prostate Cancer

Integrins α6β1 and Bnip3 were found to promote survival of castration-resistant prostate cancer cells selectively on laminin through the induction of autophagy and mitophagy.
[Oncogene]
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The MD Anderson Prostate Cancer Patient-Derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-Driven Therapy Development

Scientists studied two cell line-derived xenografts and the first 80 patient-derived xenografts (PDXs) derived from 47 human prostate cancer donors. Of these, 47 PDXs derived from 22 donors were working models and could be expanded either as cell lines or PDXs.
[Clinical Cancer Research]
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Small Molecule Inhibitors Targeting Gαi2 Protein Attenuate Migration of Cancer Cells

Researchers observed that two compounds at 10 μΜ significantly inhibited the migratory behavior of the PC3 and DU145 prostate cancer cell lines.
[Cancers]
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Biological Effect Evaluation of Glutathione-Responsive Cyclodextrin-Based Nanosponges: 2D and 3D Studies

The effect of glutathione-responsive β-cyclodextrin-based nanosponges (GSH-NS) on cell growth was evaluated on multicellular spheroids and a comparison of the GSH-NS cell growth inhibitory activity was performed between 2D and 3D cell cultures.
[Molecules]
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