Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Contemporary Concise Review 2023: Interstitial Lung Disease

Crosstalk between vascular endothelial cells and fibroblasts in Idiopathic Pulmonary Fibrosis mediated by bone morphogenic protein signalling may be important for remodeling of...

Exosomal miR-129-2-3p Promotes Airway Epithelial Barrier Disruption in PM2.5-Aggravated Asthma

The authors investigated the role of exosomal miR-129-2-3p in regulating airway epithelial cell barrier function, its potential targets, and signaling pathways involved in PM2.5-induced...

3D Cultivation of Non-Small-Cell Lung Cancer Cell Lines Using Four Different Methods

Four NSCLC cell lines, two adenocarcinomas and two squamous cell carcinomas, were first cultured in traditional 2D settings. Their expected expression profiles concerning TTF-1,...

Activatable Near-Infrared Fluorescence Probe for Real-Time Imaging of PD-L1 Expression in Tumors

Investigators presented for the first time an activatable near-infrared fluorescence imaging probe for the real-time monitoring of PD-L1 expression in vitro and in vivo....

High-Parametric Protein Maps Reveal the Spatial Organization in Early-Developing Human Lung

[FierceBiotech] Using high-parametric tissue imaging with a 30-plex antibody panel, investigators analyzed human lung samples from 6 to 13 post-conception weeks, generating data from over 2 million cells across five developmental timepoints.

Transpulmonary Chemoembolization and Microwave Ablation for Recurrent or Advanced Non-Small Cell Lung Cancer

[Scientific Reports] Scientists attempted to verify the treatment effect of the combination of transpulmonary chemoembolization (TPCE) and microwave ablation (MWA), targeting the treatment of recurrent or advanced NSCLC.

Pseudomonas aeruginosa Faces a Fitness Trade-Off Between Mucosal Colonization and Antibiotic Tolerance During Airway Infection

[Nature Microbiology] Scientists investigated P. aeruginosa growth and antibiotic tolerance in tissue-engineered airways by transposon insertion sequencing. Metabolic modelling based on Tn-seq data revealed the nutritional requirements for P. aeruginosa growth, highlighting reliance on glucose and lactate and varying requirements for amino acid biosynthesis.

MSD, Moderna Start Phase III Adjuvant Lung Cancer Trial

[PharmaPhorum] MSD and Moderna have kicked off another Phase III trial of their personalised cancer vaccine V940 used alongside MSD's PD-1 inhibitor Keytruda, this time focusing on patients with earlier-stage NSCLC.

Mechanosensitive Channels TMEM63A and TMEM63B Mediate Lung Inflation–Induced Surfactant Secretion

[Journal of Clinical Investigation] Investigators showed that loss of the mechanosensitive channels TMEM63A and TMEM63B resulted in atelectasis and respiratory failure in mice due to a deficit of surfactant secretion.

BU, Boston Medical Center Researchers Join Forces with GSK to Fight Lung Diseases

[EurekAlert!] Researchers from the Center for Regenerative Medicine at Boston University and Boston Medical Center announced a new collaboration with the global biopharma company GSK to advance innovative research focused on developing cutting-edge models to study and treat lung diseases like pulmonary fibrosis.

Rebooting the Adaptive Immune Response in Immunotherapy-Resistant Lung Adenocarcinoma Using a Supramolecular Albumin

[Small] The bioinformatics analysis of immunotherapy-resistant lung adenocarcinoma patients and the system analysis of Anti-PD1-resistant mice models once again validate that the resistance-associated Wnt/β-catenin pathway offers a promising avenue for immune checkpoint inhibitors sensitization.

The Benefit and Risk of Addition of Chemotherapy to EGFR Tyrosine Kinase Inhibitors for EGFR-Positive Non-Small Cell Lung Cancer Patients with Brain Metastases: A...

[Frontiers In Oncology] Six databases were systematically searched for relevant literatures comparing ETC versus ET in treating EGFR-positive NSCLC patients with BM. The primary outcome assessed was overall survival (OS), while secondary outcomes included progression-free survival (PFS), and central nervous system (CNS)-PFS, responses, progression status and safety.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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