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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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The N6-Methyladenosine-Mediated cLMNB1 Degrades FGFR4 to Overcome Osimertinib Resistance in Non-Small Cell Lung Cancer
[Cell Death & Disease] Researchers observed that circRNA LMNB1 increases the sensitivity of lung adenocarcinoma to osimertinib in vitro and in vivo.
MZT2B Promotes Malignant Phenotypes in NSCLC Cells by Enhancing Mitochondrial Function and COX5B Expression
[Cell Death & Disease] Investigators identified mitotic spindle organizing protein 2B (MZT2B) as a critical oncogenic driver and potential therapeutic vulnerability in NSCLC.
Small Cell Lung Cancer Induces Synaptic Scaling to Alter Neuronal Excitability
[Communications Biology] Scientists showed that small cell lung cancer (SCLC) cells can form functional synapses with neurons. Synapse-forming SCLC cells reveal a heterogeneous sensitivity to the AMPA receptor antagonist cyanquixaline and are also reduced following GABAA receptor blockade.
The Repressor Capicua Is a Barrier to Lung Tumor Development Driven by Kras/Trp53 Mutations
[EMBO Molecular Medicine] The authors identified the transcriptional repressor Capicua (CIC) as a key target inactivated by KRAS/MAPK signaling in lung adenocarcinoma. They showed that genetic loss of CIC recapitulates the phenotypic consequences of amplified KRAS signaling.
FPR1-Dependent Pro-Inflammatory Ccl4high Monocytes/Macrophages Drive and Predict Sepsis-Induced Acute Lung Injury
[Respiratory Research] Scientists employed scRNA-seq to profile the transcriptional landscape of the lungs in well-established murine models of sepsis-induced acute lung injury.
Aging Represses Oncogenic KRAS-Driven Lung Tumorigenesis and Alters Tumor Suppression
[Nature Aging] Researchers showed that aging represses oncogenic KRAS-driven tumor initiation and growth in genetically engineered mouse models of human lung cancer.
Systemic Mir-26a Deficiency Attenuates Pulmonary Fibrosis via PTEN Upregulation and Downstream TIMP-1 Suppression
[Molecular Therapy - Nucleic Acids] Scientists found that miR-26a knockout mice exhibited reduced pulmonary fibrosis compared with wild-type mice. Loss of miR-26a increases PTEN expression, a target gene of miR-26a, resulting in the reduction of Timp1 levels downstream of the PI3K/Akt-mTOR pathway, thereby attenuating fibrosis.
Over €10m EU Funding Boosts UCL Cancer and Neuroscience Research
[UCL] Three University College London (UCL) scientists have been awarded prestigious European Research Council Synergy Grants 2025 to support research into how lung cancer spreads and how the brain controls instinctive behaviours.
Immunotherapy for Small Cell Lung Cancer: Current Challenges and Prospects
[Experimental Hematology & Oncology] The authors summarize distinctive features of the tumor–immune microenvironment in small cell lung cancer and evaluate current immunotherapeutic strategies, notably immune checkpoint inhibitors, that have demonstrated survival benefits in a subset of patients.
Navigating the Landscape of EGFR TKI Resistance in EGFR-Mutant NSCLC – Mechanisms and Evolving Treatment Approaches
[Nature Reviews Clinical Oncology] The authors synthesize molecular mechanisms that underlie resistance to third-generation EGFR tyrosine kinase inhibitors and discuss emerging approaches to pre-empt resistance through early application of combination therapies.
Zanubrutinib Mitigates Pulmonary Fibrosis in Aged Mice by Targeting the Wnt/β-catenin Signaling Pathway
[Biochemical Pharmacology] The authors discussed the potential effects and mechanisms of Zanubrutinib on aging lung fibrosis in vivo and in vitro.
Alveolar Epithelial Cell-Derived Exosomes Regulate Autophagy through miR-450b-5p/HDAC7 to Improve Pulmonary Fibrosis
[FASEB Journal] A cell fibrosis model was constructed using TGF-β, and a mouse fibrosis model was constructed with bleomycin, treated with alveolar epithelial cell-derived exosomes, which was interfered with by treatment with a miR-450b-5p inhibitor.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
