Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

Long Non-Coding RNA TDRG1 Aggravates Lung Cancer Stemness by Binding to Sox2 mRNA

[Environmental Toxicology] Scientists collected 3D non-adherent spheres as the CSC model to measure lncRNA TDRG1 level in lung CSC and the parental lung cancer cells, and found that TDRG1 level was significantly upregulated in lung CSCs compared to that of parental lung cancer cells

The Influenza-Injured Lung Microenvironment Promotes MRSA Virulence, Contributing to Severe Secondary Bacterial Pneumonia

[Cell Reports] By conditioning Staphylococcus aureus (MRSA) ex vivo in bronchoalveolar lavage fluid collected from mice at various time points of influenza infection, investigators found that the influenza-injured lung microenvironment dynamically induced MRSA to increase cytotoxin expression, while decreasing metabolic pathways.

Extracellular Matrix Profiles Determine Risk and Prognosis of the Squamous Cell Carcinoma Subtype of Non-Small Cell Lung Carcinoma

[Genome Medicine] Scientists revealed subtype-specific ECM signatures associated with tumor initiation that were predictive of premalignant progression.

Promotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation

[Advanced Science] Researchers described that multiple acetyl-vWA domain-carrying proteins including integrin β3 and collagen 6A were deacetylated by Sirtuin family member SIRT2 in extracellular space.

SMARCA4: Current Status and Future Perspectives in Non-Small-Cell Lung Cancer

[Molecular Psychiatry] The authors summarize emerging new concepts in the understanding of the developing human brain and discuss how these advances could be implemented in neurodevelopmental disorder models.

A Novel Mechanism for the Protection against Acute Lung Injury by Melatonin: Mitochondrial Quality Control of Lung Epithelial Cells Is Preserved through SIRT3-Dependent Deacetylation...

[Cellular and Molecular Life Sciences] Researchers investigated whether melatonin could protect against sepsis-induced acute lung injury (ALI) and LPS-treated lung epithelial cells through the mitochondrial quality control as well as its possible molecular targets.

Mitochondrial Citrate Accumulation Drives Alveolar Epithelial Cell Necroptosis in Lipopolysaccharide-Induced Acute Lung Injury

[Experimental & Molecular Medicine] The authors examined citratemt accumulation in alveolar epithelial cells that were challenged with lipopolysaccharide ex vivo and in vivo.

Combination of Esomeprazole and Pirfenidone Enhances Antifibrotic Efficacy In Vitro and in a Mouse Model of TGFβ-Induced Lung Fibrosis

[Scientific Reports] Investigators evaluated the anti-fibrotic efficacy of the proton pump inhibitor esomeprazole when combined with pirfenidone in vitro and in vivo.

PRKCA Promotes Mitophagy through the miR-15a-5p/PDK4 Axis to Relieve Sepsis-Induced Acute Lung Injury

[Infection and Immunity] The Protein kinase C-alpha (PRKCA)/miR-15a-5p/PDK4 axis alleviated acute lung injury caused by sepsis by promoting mitophagy and repressing anti-inflammatory response both In vivo and in vitro.

NFκB Induces Epigenetic Repression of GPRC5A in Lung Epithelial Cells to Promote Neoplasia

[JCI Insight] Scientists showed that NF-κB acts as a transcriptional repressor in the suppression of GPRC5A. NF-κB induced GPRC5A repression both in vitro and in vivo.

The Roles of CPSF6 in Proliferation, Apoptosis and Tumorigenicity of Lung Adenocarcinoma

[Aging] Researchers found that CPSF6 was significantly higher expressed in tumor tissues than in normal tissues in multiple cancer types.

Targeting BET Proteins Inhibited the Growth of Non-Small Cell Lung Carcinoma through Downregulation of Met Expression

[Cell Biology International] Investigators found that JQ1, a bromodomain and extra terminal domain (BET) inhibitor, suppressed NSCLC cell growth, reduced the Met expression, and contributed to inactivation of PI3K/Akt and MAPK/ERK pathways.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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