Synergistic Effects of Bcl-2 Inhibitors with AZD9291 on Overcoming the Acquired Resistance of AZD9291 in H1975 Cells

Significant upregulation of Bcl-2 was found in AZD9291-resistant H1975 cells compared with H1975, which may constitute an important resistant mechanism of acquired resistance to AZD9291.
[Archives of Toxicology]
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miR-223 Regulates Autophagy Associated with Cisplatin Resistance by Targeting FBXW7 in Human Non-Small Cell Lung Cancer

Investigators found that the level of miR-223 was significantly positively correlated with cisplatin resistance. miR-223 overexpression made NSCLC cells resistant to cisplatin treatment.
[Cancer Cell International]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Multiple Low Dose Therapy as an Effective Strategy to Treat EGFR Inhibitor-Resistant NSCLC Tumors

The authors showed that as little as 20% of the individual effective drug doses was sufficient to completely block MAPK signaling and proliferation when used in 3D or 4D inhibitor combinations.
[Nature Communications]
Fernandes Neto, J. M., Nadal, E., Bosdriesz, E., Ooft, S. N., Farre, L., McLean, C., Klarenbeek, S., Jurgens, A., Hagen, H., Wang, L., Felip, E., Martinez-Marti, A., Vidal, A., Voest, E., Wessels, L. F. A., van Tellingen, O., Villanueva, A., & Bernards, R. (2020). Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours. Nature Communications, 11(1), 3157. https://doi.org/10.1038/s41467-020-16952-9 Cite
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NMPA Accepts Bio-Thera Solutions’ Biologics License Application (BLA) for BAT1706, A Proposed Biosimilar to Avastin®

Bio-Thera Solutions announced that the China National Medical Products Administration (NMPA) has accepted the Biologics License Application for BAT1706, a proposed biosimilar to Avastin®.
[Bio-Thera Solutions (Business Wire, Inc.)]
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YBX1 Mediates Autophagy by Targeting p110β and Decreasing the Sensitivity to Cisplatin in NSCLC

Scientists analyzed the expression and clinical significance of Y-box binding protein 1 and markers of autophagy in NSCLC and examined their roles in regulating sensitivity to cisplatin in NSCLC.
[Cell Death & Disease]
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Targeting Lung Cancer Stem Cells Using Combination of Tel and Docetaxel Liposomes in 3D Cultures and Tumor Xenografts

Scientists demonstrated for the first time the efficacy of Docetaxel liposomes in combination with telmisartan in 3D cultures of H460 cells by using polysaccharide-based hydrogels and also in xenograft model of Docetaxel resistant H460 derived CD133+ lung tumors.
[Toxicology and Applied Pharmacology]
Arthur, P., Patel, N., Surapaneni, S. K., Mondal, A., Gebeyehu, A., Bagde, A., Kutlehria, S., Nottingham, E., & Singh, M. (2020). Targeting lung cancer stem cells using combination of Tel and Docetaxel liposomes in 3D cultures and tumor xenografts. Toxicology and Applied Pharmacology, 115112. https://doi.org/10.1016/j.taap.2020.115112 Cite
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