Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging

Using transgenic mice and pharmacologic studies, the authors found that Wnt/β-catenin within airway basal stem cells was essential for proliferation post-injury in vivo.
[Cell Stem Cell]
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Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma (LADC). Extensive gene and histopathology profiling show that the tumor organoids retain the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
[iScience]
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CircSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer by Targeting miR-520h/ABCG2 Pathway

The authors determined circSETD3 was significantly upregulated in gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines and the plasma of gefitinib-resistant NSCLC patients.
[Molecular Therapy-Nucleic Acids]
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HMGA2 Regulates Circular RNA ASPH to Promote Tumor Growth in Lung Adenocarcinoma

Researchers identified a circular form of ASPH RNA, expression of which was upregulated in lung adenocarcinoma and the human lung adenocarcinoma cell lines.
[Cell Death & Disease]
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French Science Bill Promises Boost to Public R&D

The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider]
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Foreign Researchers Accused of Hiding Links to Chinese Military

Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist]
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Chloroquine Does Not Inhibit Infection of Human Lung Cells with SARS-CoV-2

Researchers showed that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells, rendered SARS-CoV-2 infection of Vero cells insensitive to chloroquine.
[Nature]
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Breztri Aerosphere Approved in the US for the Maintenance Treatment of COPD

AstraZeneca’s Breztri Aerosphere has been approved in the US for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD).
[AstraZeneca]
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Daiichi Sankyo and Gustave Roussy Enter Innovative Research Collaboration for DXd ADCs DS-1062 and Patritumab Deruxtecan

Daiichi Sankyo Company, Limited and Gustave Roussy announced a multi-year, multi-study research collaboration to enrich and further enable the development of DS-1062 and patritumab deruxtecan, two of Daiichi Sankyo’s lead DXd antibody drug conjugates, in lung and breast cancer.
[Daiichi-Sankyo]
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Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

The authors profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma.
[Cancer Cell]
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Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

Scientists used single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma. They identified an epigenomic continuum representing loss of cellular identity and progression toward a metastatic state.
[Cancer Cell]
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