Using transgenic mice and pharmacologic studies, the authors found that Wnt/β-catenin within airway basal stem cells was essential for proliferation post-injury in vivo.
[Cell Stem Cell]
1254621 FWAKUQYC items 1 apa default asc 1
Scientists established 12 patient-derived organoids from the most common lung cancer subtype, lung adenocarcinoma (LADC). Extensive gene and histopathology profiling show that the tumor organoids retain the histological architectures, genomic landscapes, and gene expression profiles of their parental tumors.
1254621 VA8XQQLM items 1 apa default asc 1
The authors determined circSETD3 was significantly upregulated in gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines and the plasma of gefitinib-resistant NSCLC patients.
[Molecular Therapy-Nucleic Acids]
1254621 59SZ2B9G items 1 apa default asc 1
Researchers identified a circular form of ASPH RNA, expression of which was upregulated in lung adenocarcinoma and the human lung adenocarcinoma cell lines.
[Cell Death & Disease]
1254621 GI7V7ZVT items 1 apa default asc 1
The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
Researchers showed that engineered expression of TMPRSS2, a cellular protease that activates SARS-CoV-2 for entry into lung cells, rendered SARS-CoV-2 infection of Vero cells insensitive to chloroquine.
1254621 XKAYZZHN items 1 apa default asc 1
AstraZeneca’s Breztri Aerosphere has been approved in the US for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD).
Daiichi Sankyo Company, Limited and Gustave Roussy announced a multi-year, multi-study research collaboration to enrich and further enable the development of DS-1062 and patritumab deruxtecan, two of Daiichi Sankyo’s lead DXd antibody drug conjugates, in lung and breast cancer.
The authors profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma.
1254621 ICFFXRMS items 1 apa default asc 1
Scientists used single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma. They identified an epigenomic continuum representing loss of cellular identity and progression toward a metastatic state.
1254621 I3RVA22D items 1 apa default asc 1