NRF2-GPX4/SOD2 Axis Imparts Resistance to EGFR-Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cells

The authors investigated the role of NRF2 in resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). They showed that NRF2 protein levels were markedly increased in a panel of EGFR-TKI-resistant non-small cell lung cancer cell lines due to slow degradation of NRF2 protein.
[Acta Pharmacologica Sinica]
Abstract
Bookmark

No account yet? Register

0
Share

Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma

Scientists investigated tumor-associated macrophage (TAM) subtype density and distribution between tumor center and invasive margin in human lung cancer and TAM associations with overall survival.
[Cancer Research]
Abstract
Bookmark

No account yet? Register

0
Share

Cell–Cell Interaction Mechanisms in Acute Lung Injury

The authors provide an overview of current advancements in understanding the role of cell–cell interaction in the development of acute lung injury (ALI) and depict molecular mechanisms by which cell–cell interactions regulate lung inflammation, focusing on inter-cellular activities and signaling pathways that point to possible therapeutic opportunities for ALI/acute respiratory distress syndrome.
[Shock]
Abstract
Bookmark

No account yet? Register

0
Share

Lantern Pharma Establishes Manufacturing Network in Preparation for Its Phase II Clinical Trial for the Treatment of Non-Small Cell Lung Cancer and a Phase I Clinical Trial for Solid Tumors and Glioblastoma

Lantern Pharma announced entering into agreements with leading contract manufacturing companies for process development and manufacturing for two of Lantern’s oncology drug candidates, LP-300 and LP-184.
[Lantern Pharma Inc.]
Press Release
Bookmark

No account yet? Register

0
Share

Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider]
Press Release
Bookmark

No account yet? Register

0
Share

Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
Press Release
Bookmark

No account yet? Register

0
Share

Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia

Researchers used reconstituted human airway epithelia to isolate and then characterized the viral infection kinetics, tissue-level remodeling of the cellular ultrastructure, and transcriptional early immune signatures induced by SARS-CoV-2 in a physiologically relevant model.
[Cell Reports Medicine]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Post-Transcriptional Air Pollution Oxidation to the Cholesterol Biosynthesis Pathway Promotes Pulmonary Stress Phenotypes

Investigators develop a method for 8-oxo-7,8-dihydroguanine profiling using immunocapturing and RNA sequencing. They found 42 oxidized transcripts in bronchial epithelial BEAS-2B cells exposed to two air pollution mixtures that recreate urban atmospheres.
[Communications Biology]
Full Article
Bookmark

No account yet? Register

0
Share

Sanford Burnham Prebys Receives CIRM Award for COVID-19 Research

Sanford Burnham Prebys Medical Discovery Institute has received an award from the California Institute for Regenerative Medicine to advance promising drug candidates for COVID-19.
[Sanford Burnham Prebys Medical Discovery Institute]
Press Release
Bookmark

No account yet? Register

0
Share

Single Cell Reconstruction of Human Basal Cell Diversity in Normal and IPF Lung

Researchers sought to decipher the transcriptome of freshly isolated epithelial cells from normal and idiopathic pulmonary fibrosis lung to discern disease-dependent changes within basal stem cells.
[American Journal of Respiratory and Critical Care Medicine]
Abstract
Bookmark

No account yet? Register

0
Share

Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection

In the context of Pseudomonas aeruginosa infection, brushings from the airways of cystic fibrosis recipients demonstrate type 1 interferon gene suppression.
[Cell Reports Medicine]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share
Share