The authors investigated the role of NRF2 in resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). They showed that NRF2 protein levels were markedly increased in a panel of EGFR-TKI-resistant non-small cell lung cancer cell lines due to slow degradation of NRF2 protein.
[Acta Pharmacologica Sinica]
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Scientists investigated tumor-associated macrophage (TAM) subtype density and distribution between tumor center and invasive margin in human lung cancer and TAM associations with overall survival.
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The authors provide an overview of current advancements in understanding the role of cell–cell interaction in the development of acute lung injury (ALI) and depict molecular mechanisms by which cell–cell interactions regulate lung inflammation, focusing on inter-cellular activities and signaling pathways that point to possible therapeutic opportunities for ALI/acute respiratory distress syndrome.
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Lantern Pharma announced entering into agreements with leading contract manufacturing companies for process development and manufacturing for two of Lantern’s oncology drug candidates, LP-300 and LP-184.
[Lantern Pharma Inc.]
For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
Researchers used reconstituted human airway epithelia to isolate and then characterized the viral infection kinetics, tissue-level remodeling of the cellular ultrastructure, and transcriptional early immune signatures induced by SARS-CoV-2 in a physiologically relevant model.
[Cell Reports Medicine]
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Investigators develop a method for 8-oxo-7,8-dihydroguanine profiling using immunocapturing and RNA sequencing. They found 42 oxidized transcripts in bronchial epithelial BEAS-2B cells exposed to two air pollution mixtures that recreate urban atmospheres.
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Sanford Burnham Prebys Medical Discovery Institute has received an award from the California Institute for Regenerative Medicine to advance promising drug candidates for COVID-19.
[Sanford Burnham Prebys Medical Discovery Institute]
Researchers sought to decipher the transcriptome of freshly isolated epithelial cells from normal and idiopathic pulmonary fibrosis lung to discern disease-dependent changes within basal stem cells.
[American Journal of Respiratory and Critical Care Medicine]
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In the context of Pseudomonas aeruginosa infection, brushings from the airways of cystic fibrosis recipients demonstrate type 1 interferon gene suppression.
[Cell Reports Medicine]