Resistance to Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: Biomarkers and Therapeutic Strategies

The authors highlight the absence of a common definition of primary and secondary resistance and summarize their frequency and clinical characteristics.
[Therapeutic Advances in Medical Oncology]
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Ubiquitin Ligase SMURF2 Enhances Epidermal Growth Factor Receptor Stability and Tyrosine-Kinase Inhibitor Resistance

Scientists identified four lysine residues as the sites of ubiquitination, and showed that replacement of one of them with acetylation-mimicking glutamine increased the sensitivity of mutant EGFR to erlotinib-induced degradation.
[Journal of Biological Chemistry]
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ASXL3 Bridges BRD4 to BAP1 Complex and Governs Enhancer Activity in Small Cell Lung Cancer

Biochemistry studies, including size exclusion chromatography, mass spectrometry, and western blot analysis, were conducted to determine the protein-protein interaction between additional sex combs-like protein 3 (ASXL3) and bromodomain-containing protein 4.
[Genome Medicine]
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Calithera Biosciences Initiates Phase Ib Trial of Arginase Inhibitor CB-280 for the Treatment of Cystic Fibrosis

Calithera Biosciences, Inc. announced that it has dosed the first patients in its Phase Ib clinical trial of the arginase inhibitor CB-280 in adult patients with cystic fibrosis and chronic airway infection. The study will evaluate the safety and optimal dose range of CB-280 when added onto existing therapies for cystic fibrosis patients, including CFTR modulators.
[Calithera Biosciences, Inc. ]
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During the Pandemic, Students Do Field and Lab Work without Leaving Home

Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
[Science Insider]
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Therapeutic Targeting of 15-PGDH in Murine Pulmonary Fibrosis

Long-term pharmacologic 15-PGDH inhibition (PGDHi) was well-tolerated, reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling, and improved pulmonary function in bleomycin-treated mice.
[Scientific Reports]
Smith, J. N. P., Witkin, M. D., Jogasuria, A. P., Christo, K. F., Raffay, T. M., Markowitz, S. D., & Desai, A. B. (2020). Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis. Scientific Reports, 10(1), 11657. https://doi.org/10.1038/s41598-020-68336-0 Cite
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An Analysis of Ways to Decarbonize Conference Travel after COVID-19

The COVID-19 pandemic has forced us to rethink what constitutes necessary travel. Many of this year’s conferences have been cancelled. Some have gone virtual. Nature presents an original analysis of the potential emissions savings of doing things differently.
[Nature News]
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Journals Endorse New Checklist to Clean Up Sloppy Animal Research

To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider]
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Foreign Students in US: Trump Administration Drops Deportation Plans

US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.
[BBC]
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DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies Crebbp as a Predictive Biomarker of Volasertib in Small Cell Lung Carcinoma (SCLC)

Applying DrugSniper to SCLC, scientists identified genes extensively explored in SCLC. The analysis suggested a remarkable vulnerability to polo-like kinase 1 inhibition in CREBBP-mutant SCLC cells.
[Cancers]
Carazo, F., Bértolo, C., Castilla, C., Cendoya, X., Campuzano, L., Serrano, D., … Rubio, A. (2020). DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC). Cancers, 12(7), 1824. https://doi.org/10.3390/cancers12071824 Cite
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Persistence of a Regeneration-Associated, Transitional Alveolar Epithelial Cell State in Pulmonary Fibrosis

Using lung organoids, multiple in vivo repair models, single-cell transcriptomics and lineage tracing, researchers found that alveolar type-2 epithelial cells undergoing differentiation into type-1 cells acquired pre-alveolar type-1 transitional cell state en route to terminal maturation.
[Nature Cell Biology]
Kobayashi, Y., Tata, A., Konkimalla, A., Katsura, H., Lee, R. F., Ou, J., … Tata, P. R. (2020). Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. Nature Cell Biology, 1–13. https://doi.org/10.1038/s41556-020-0542-8 Cite
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