β-cells

[Journal of Diabetes Research] Scientists review recent study updates of sphingosine 1 phosphate (S1P), summarizing its effects on type 2 diabetes mellitus with respect to pathogenesis, promoting β cell proliferation and inhibiting apoptosis, reducing insulin resistance, protecting the liver and pancreas from lipotoxic damage, improving intestinal incretin effects, lowering basal glucagon levels, etc.

[Circulation Journal] Researchers suggest that careful assessment of the status of converted cells using genetic and epigenetic profiling, various functional assays, and the use of multiple readouts is essential to determine successful conversion.

[Endocrine Journal] The toxic heavy metal cadmium has been proven to cause pancreatic dysfunction and lead to the development of DM. Researchers investigated the effects of cadmium on the pancreatic β cell line MIN6 and explored the underlying mechanisms.

[Febs Open Bio] Scientists reported that derrisfolin A induced the expression of endogenous regucalcin protein in both pancreatic MIN6 β-cells and RAW264.7 macrophages.

[Bioengineered] The effect of astragalus polysaccharide on dysfunctional insulin cells was investigated to clarify whether astragalus polysaccharide could be a novel drug for type 2 diabetes mellitus treatment.

[Scientific Reports] Investigators elucidated whether regulation of growth hormone secretagogue receptor-1a (GHS-R1a), one of the ghrelin receptors, improved the therapeutic effects of islet transplantation using [D-Lys3]-GHRP-6, a specific GHS-R1a antagonist.