β-cells

[Journal of Biochemical and Molecular Toxicology] Scientists delineated the role of gymnemic acid in protecting pancreatic β-cells in diabetic animals, with special reference to inflammation and apoptosis.

[Acta Diabetologica] CCK8, Ki67 staining, immunohistochemical analyses, glucose-stimulated insulin secretion and intraperitoneal glucose tolerance test were performed to detect the effect of Kcnq1ot1 on β-cell proliferation and insulin secretion in vitro and in vivo.

[Inflammation Research] Scientists demonstrated the protective role of Insulin-like growth factor 1 (IGF-1) against pancreatic β cell dysfunction and to probe into the underlying mechanisms.

[The Lundquist Institute (Cision US, Inc.)] The Lundquist Institute's investigator Dr. Eiji Yoshihara has received a five-year $749,995.50 Career Development Award from the Juvenile Diabetes Research Foundation for his proposed study on how human β cells gain immune evasive function by environmental cues.

[Communications Biology] To discriminate the role of PFKFB3 from HIF1α in vivo, scientists generated mice with conditional β-cell specific disruption of the Pfkfb3 gene on a human islet pancreatic polypeptide background and a high-fat diet.

[iScience] Scientists showed that intracellular Ca2+ and reactive oxygen species signals generated by high glucose and cytokine-induced endoplasmic reticulum stress activated calcineurin/NFATc2 and PI3K/AKT to maintain β-cell identity and function.