β-cells

[JCI Insight] Scientists found that Notch activation in postnatal β cells impaired glucose-stimulated insulin secretion and glucose intolerance, but also observed a remnant glucose intolerance after doxycycline withdrawal and cessation of Notch activity, associated with a marked disruption of normal islet architecture.

[Nature Communications] Scientists studied the role of lysosomal Ca2+ in transcription Factor EB (TFEB) activation by mitochondrial or metabolic stress and that of TFEB-mediated mitophagy in pancreatic β-cell function.

[Cellular and Molecular Life Sciences] Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.

[Frontiers in Immunology] The authors used multiplex immunofluorescence imaging analysis to characterize MDA5 expression and distribution in pancreatic tissues obtained from 22 organ donors.

[Current Diabetes Reports] Investigators focus on the recent development of new clinically validated and novel biomarkers as well as the methods that represent cost-effective alternatives for screening and early diagnosis of type 2 diabetes mellitus.

[Journal of Genetics and Genomics] The authors summarize the roles and underlying mechanisms of transcription factors in the maintenance of β-cell identity under physiological and type 2 diabetic conditions.