β-cells

[Stem Cell Reports] Scientists described the generation of an array of monoclonal antibodies against cell surface markers that selectively label stem cell-derived islet cells.

[Cell Reports] Scientists used maturity-onset diabetes of a young 3 patient and CRISPR/Cas9-engineered human induced pluripotent stem cells (hiPSC) grown as 3D organoids to investigate how HNF1αp291fsinsC affected hiPSC differentiation during pancreatic development.

[Nature Metabolism] Mechanistically, the protective role of microsomal prostaglandin E synthase-2 (mPGES-2) deletion was induced by antagonizing β-cell senescence via interference of the PGE2–EP3–NR4A1 signaling axis.

[Free Radical Biology and Medicine] Researchers investigated whether peri-pancreatic white adipose tissue produced oxygenated lipids, namely isoprostanes and neuroprostanes and whether they can influence β-cell function in obesity.

[Journal of Trace Elements in Medicine and Biology] Scientists used an in vitro MIN6 cell model of environment-relevant cadmium exposure to elucidate the crucial role of mtROS-mediated mitochondrial dysfunction and inflammatory response in suppression of pancreatic β-cell insulin secretion.

[Journal of Trace Elements in Medicine and Biology] Scientists used an in vitro MIN6 cell model of environment-relevant cadmium exposure to elucidate the crucial role of mtROS-mediated mitochondrial dysfunction and inflammatory response in suppression of pancreatic β-cell insulin secretion.