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2025

Inhibition of ENT1 Relieves Intracellular Adenosine-Mediated T Cell Suppression in Cancer

Researchers showed that adenosine suppresses anti-cancer T cell responses following uptake into activated T cells by equilibrative nucleoside transporter 1 (ENT1) and inhibition of de novo pyrimidine nucleotide synthesis. [Nature Immunology] Full Article

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