Targeting EphA2 Suppresses Hepatocellular Carcinoma Initiation and Progression by Dual Inhibition of JAK1/STAT3 and AKT Signaling

The authors discovered that targeting EphA2 suppressed both AKT and JAK1/STAT3 signaling, two separate oncogenic pathways in hepatocelllar carcinoma.
[Cell Reports]
Wang, H., Hou, W., Perera, A., Bettler, C., Beach, J. R., Ding, X., Li, J., Denning, M. F., Dhanarajan, A., Cotler, S. J., Joyce, C., Yin, J., Ahmed, F., Roberts, L. R., & Qiu, W. (2021). Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108765 Cite
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LRP1 Mediates the IGF-1-Induced GLUT1 Expression on the Cell Surface and Glucose Uptake in Müller Glial Cells

The authors investigated whether Insulin-like Growth Factor-1 (IGF-1) modulates glucose transporter type 1 (GLUT1) traffic to plasma membrane (PM) and glucose uptake, as well as the involvement of Low-density lipoprotein Receptor-related Protein-1 (LRP1) in this process in the human Müller glial-derived cell line.
[Scientific Reports]
Actis Dato, V., Sánchez, M. C., & Chiabrando, G. A. (2021). LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells. Scientific Reports, 11(1), 4742. https://doi.org/10.1038/s41598-021-84090-3 Cite
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BKM120 Sensitizes BRCA-Proficient Triple Negative Breast Cancer Cells to Olaparib through Regulating FOXM1 and Exo1 Expression

Scientists found that dual phosphoinositide 3-kinase (PI3K) and poly (ADP-ribose) polymerase inhibition with BKM120 and olaparib significantly reduced the proliferation of BRCA-proficient TNBC cell lines.
[Scientific Reports]
Li, Y., Wang, Y., Zhang, W., Wang, X., Chen, L., & Wang, S. (2021). BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. Scientific Reports, 11(1), 4774. https://doi.org/10.1038/s41598-021-82990-y Cite
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Cannabidiol Inhibits Human Glioma by Induction of Lethal Mitophagy Through Activating TRPV4

Researchers investigated the molecular mechanisms underlying the antitumor effect of cannabidiol in preclinical models of human glioma.
[Autophagy]
Huang, T., Xu, T., Wang, Y., Zhou, Y., Yu, D., Wang, Z., He, L., Chen, Z., Zhang, Y., Davidson, D., Dai, Y., Hang, C., Liu, X., & Yan, C. (2021). Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. Autophagy. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1885203 Cite
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Pentraxin 3 Acts as a Functional Effector of Akt/NF-κB Signaling to Modulate the Progression and Cisplatin-Resistance in Non-Small Cell Lung Cancer

The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.
[Archives of Biochemistry and Biophysics]
Li, Y., Song, X., Niu, J., Ren, M., Tang, G., Sun, Z., & Kong, F. (2021). Pentraxin 3 acts as a functional effector of Akt/NF-κB signaling to modulate the progression and cisplatin-resistance in non-small cell lung cancer. Archives of Biochemistry and Biophysics, 108818. https://doi.org/10.1016/j.abb.2021.108818 Cite
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Akt‐Independent Effects of Triciribine on ACE2 Expression in Human Lung Epithelial Cells: Potential Benefits in Restricting SARS‐CoV2 Infection

Investigators tested the direct effect of triciribine on ACE2 expression in human bronchial (H441) and lung alveolar (A549) epithelial cells.
[Journal of Cellular Physiology]
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DGKA Mediates Resistance to PD-1 Blockade

Scientists demonstrated that diacylglycerol kinase alpha (Dgka) mediated T-cell dysfunction during anti-PD-1 therapy by exacerbating the exhaustion of reinvigorated tumor-specific T cells.
[Cancer Immunology Research]
Fu, L., Li, S., Xiao, W., Yu, K., Li, S., Yuan, S., Shen, J., Dong, X., Fang, Z., Zhang, J., Chen, S., Li, W., You, H., Xia, X., Kang, T., Tan, J., Chen, G., Yang, A.-K., Gao, Y., & Zhou, P. (2021). DGKA Mediates Resistance to PD-1 Blockade. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0216 Cite
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IRF4 Modulates the Response to BCR Activation in Chronic Lymphocytic Leukemia Regulating IKAROS and SYK

Scientists modulated IRF4 levels by transfecting chronic lymphocytic leukemia cells with an IRF4 vector or by silencing using small-interfering RNAs.
[Leukemia]
Maffei, R., Fiorcari, S., Benatti, S., Atene, C. G., Martinelli, S., Zucchini, P., Potenza, L., Luppi, M., & Marasca, R. (2021). IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK. Leukemia, 1–14. https://doi.org/10.1038/s41375-021-01178-5 Cite
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Human Mesenchymal Stem Cells Promote Ischemic Repairment and Angiogenesis of Diabetic Foot through Exosome miRNA-21-5p

Exosomes were isolated from MSCs using ultracentrifugation, and further characterized by the nanoparticle tracking analyzer and flow cytometry. RNA sequencing, Western Blot, in vitro cell proliferation, in vivo pro-angiogenesis, as well as ischemic repairment of diabetic foot through rat model were performed to evaluate exosome physiological functions.
[Stem Cell Research]
Huang, C., Luo, W., Wang, Q., Ye, Y., Fan, J., Lin, L., Shi, C., Wei, W., Chen, H., Wu, Y., & Tang, Y. (2021). Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p. Stem Cell Research, 52, 102235. https://doi.org/10.1016/j.scr.2021.102235 Cite
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A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells

Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.
[Nutrition and Cancer]
Terasaki, M., Takahashi, S., Nishimura, R., Kubota, A., Kojima, H., Ohta, T., Hamada, J., Kuramitsu, Y., Maeda, H., Miyashita, K., Takahashi, M., & Mutoh, M. (2021). A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2020.1863994 Cite
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Moringa oleifera Leaf Extracts Protect BMSC Osteogenic Induction Following Peroxidative Damage by Activating the PI3K/Akt/Foxo1 Pathway

Researchers investigated the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow MSCs (BMSCs) following peroxidative damage and to explore the underlying mechanisms.
[Journal of Orthopaedic Surgery and Research]
Liu, M., Ding, H., Wang, H., Wang, M., Wu, X., Gan, L., Cheng, L., & Li, X. (2021). Moringa oleifera leaf extracts protect BMSC osteogenic induction following peroxidative damage by activating the PI3K/Akt/Foxo1 pathway. Journal of Orthopaedic Surgery and Research, 16(1), 150. https://doi.org/10.1186/s13018-021-02284-x Cite
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