Tag Archives: AKT

Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through MiR-17-5p-mediated Enhancement of Angiogenesis

Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
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Regulation of Amyloid-β Levels by Matrix Metalloproteinase-2/9 (MMP2/9) in the Media of Lung Cancer Cells

identify regulators of intact amyloid-β40/42 (Aβ) levels in A549 (p53 wild-type) and H1299 (p53-null) lung cancer cell media.
[Scientific Reports]
Dorandish, S., Williams, A., Atali, S., Sendo, S., Price, D., Thompson, C., Guthrie, J., Heyl, D., & Evans, H. G. (2021). Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells. Scientific Reports, 11(1), 9708. https://doi.org/10.1038/s41598-021-88574-0 Cite
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Prostate Cancer Patient-Derived Organoids: Detailed Outcome from a Prospective Cohort of 81 Clinical Specimens

Investigators report on efforts to generate patient‐derived organoids from a cohort of 81 prostate cancer specimens with diverse pathological and clinical features. They comprehensively analyzed histological features of each enrolled sample and correlated it with organoid growth patterns.
[Journal of Pathology]
Servant, R., Garioni, M., Vlajnic, T., Blind, M., Pueschel, H., Müller, D. C., Zellweger, T., Templeton, A. J., Garofoli, A., Maletti, S., Piscuoglio, S., Rubin, M. A., Seifert, H., Rentsch, C. A., Bubendorf, L., & Magnen, C. L. (n.d.). Prostate cancer patient-derived organoids: detailed outcome from a prospective cohort of 81 clinical specimens. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5698 Cite
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PXDN Reduces Autophagic Flux in Insulin-Resistant Cardiomyocytes via Modulating FoxO1

Scientists report the suppression of cell viability and autophagic flux, as shown by autophagosomes accumulation and increased expression level of LC3-II and p62 in cultured H9C2 and human AC16 cells treated with 400 μM palmitate acid for 24 h.
[Cell Death & Disease]
Li, C., Liu, Z., Xu, Q., Peng, H., Cao, J., Zhou, H., Zhang, G., Cheng, G., & Shi, R. (2021). PXDN reduces autophagic flux in insulin-resistant cardiomyocytes via modulating FoxO1. Cell Death & Disease, 12(5), 1–12. https://doi.org/10.1038/s41419-021-03699-4 Cite
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POU2F2 Regulates Glycolytic Reprogramming and Glioblastoma Progression via PDPK1-Dependent Activation of PI3K/AKT/mTOR Pathway

Researchers identified that the highly expressed POU Class Homeobox 2 (POU2F2) significantly correlated with poor prognosis of glioblastoma patients. POU2F2 promoted cell proliferation and regulated glycolytic reprogramming.
[Cell Death & Disease]
Yang, R., Wang, M., Zhang, G., Li, Y., Wang, L., & Cui, H. (2021). POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway. Cell Death & Disease, 12(5), 1–14. https://doi.org/10.1038/s41419-021-03719-3 Cite
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EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

Researchers established two sorafenib-resistant, patient-derived tumor xenografts (PDX) that mimicked development of acquired resistance to sorafenib in HCC patients.
[Cancer Research]
Leung, H.-W., Leung, C. O.-N., Lau, E. Y., Chung, K. P. S., Mok, E. H., Lei, M. M. L., Leung, R. W. H., Tong, M., Keng, V. W., Ma, C., Zhao, Q., Ng, I. O.-L., Ma, S., & Lee, T. K. (2021). EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-0184 Cite
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PD-L1 Signaling on Human Memory CD4+ T Cells Induces a Regulatory Phenotype

Researchers demonstrated that programmed death cell receptor 1 (PD-1) ligation on human CD25-depleted CD4+ T cells, combined with CD3/TCR stimulation, induced their conversion into highly suppressive T cells.
[PLOS Biology]
Fanelli, G., Romano, M., Nova-Lamperti, E., Sunderland, M. W., Nerviani, A., Scottà, C., Bombardieri, M., Quezada, S. A., Sacks, S. H., Noelle, R. J., Pitzalis, C., Lechler, R. I., Lombardi, G., & Becker, P. D. (2021). PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype. PLOS Biology, 19(4), e3001199. https://doi.org/10.1371/journal.pbio.3001199 Cite
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Nano-Realgar Suppresses Lung Cancer Stem Cell Growth by Repressing Metabolic Reprogramming

Isolation and characterization of lung cancer stem cells was performed by magnetic cell sorting and immunocytochemistry, respectively.
[Gene]
Yang, F., Zhao, Y., Hu, X., Liu, Z., Yu, X., Li, C., Li, X., & Li, H. (2021). Nano-realgar suppresses lung cancer stem cell growth by repressing metabolic reprogramming. Gene, 788, 145666. https://doi.org/10.1016/j.gene.2021.145666 Cite
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EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

Scientists established two sorafenib-resistant, patient-derived tumor xenografts that mimicked development of acquired resistance to sorafenib in hepatocellular carcinoma patients.
[Cancer Research]
Leung, H.-W., Leung, C. O.-N., Lau, E. Y., Chung, K. P. S., Mok, E. H., Lei, M. M. L., Leung, R. W. H., Tong, M., Keng, V. W., Ma, C., Zhao, Q., Ng, I. O.-L., Ma, S., & Lee, T. K. (2021). EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-21-0184 Cite
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A Novel Cystathionine γ-Lyase Inhibitor, I194496, Inhibits the Growth and Metastasis of Human TNBC via Downregulating Multiple Signaling Pathways

Scientists investigated the activity of the novel cystathionine γ-lyase inhibitor I194496 against TNBC in vivo and in vitro. The anticancer activity of I194496 in vitro were detected by MTS, EdU, and transwell assays.
[Scientific Reports]
Liu, Y., Wang, L., Zhang, X., Deng, Y., Pan, L., Li, H., Shi, X., & Wang, T. (2021). A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways. Scientific Reports, 11(1), 8963. https://doi.org/10.1038/s41598-021-88355-9 Cite
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Apatinib Suppresses the Migration, Invasion and Angiogenesis of Hepatocellular Carcinoma Cells by Blocking VEGF and PI3K/AKT Signaling Pathways

Apatinib was used to treat hepatocellular carcinoma (HCC) cells transfected with or without VEGFR2 overexpression vectors. The proliferation of HCC cells was detected by MTT assay.
[Molecular Medicine Reports]
Song, J., Guan, Z., Song, C., Li, M., Gao, Z., & Zhao, Y. (2021). Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways. Molecular Medicine Reports, 23(6), 1–8. https://doi.org/10.3892/mmr.2021.12068 Cite
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