The authors discovered that targeting EphA2 suppressed both AKT and JAK1/STAT3 signaling, two separate oncogenic pathways in hepatocelllar carcinoma.
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Wang, H., Hou, W., Perera, A., Bettler, C., Beach, J. R., Ding, X., Li, J., Denning, M. F., Dhanarajan, A., Cotler, S. J., Joyce, C., Yin, J., Ahmed, F., Roberts, L. R., & Qiu, W. (2021). Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Cell Reports, 34(8). https://doi.org/10.1016/j.celrep.2021.108765 Cite
The authors investigated whether Insulin-like Growth Factor-1 (IGF-1) modulates glucose transporter type 1 (GLUT1) traffic to plasma membrane (PM) and glucose uptake, as well as the involvement of Low-density lipoprotein Receptor-related Protein-1 (LRP1) in this process in the human Müller glial-derived cell line.
Scientists found that dual phosphoinositide 3-kinase (PI3K) and poly (ADP-ribose) polymerase inhibition with BKM120 and olaparib significantly reduced the proliferation of BRCA-proficient TNBC cell lines.
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Researchers investigated the molecular mechanisms underlying the antitumor effect of cannabidiol in preclinical models of human glioma.
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Huang, T., Xu, T., Wang, Y., Zhou, Y., Yu, D., Wang, Z., He, L., Chen, Z., Zhang, Y., Davidson, D., Dai, Y., Hang, C., Liu, X., & Yan, C. (2021). Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. Autophagy. https://www.tandfonline.com/doi/abs/10.1080/15548627.2021.1885203 Cite
The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.
[Archives of Biochemistry and Biophysics]
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Li, Y., Song, X., Niu, J., Ren, M., Tang, G., Sun, Z., & Kong, F. (2021). Pentraxin 3 acts as a functional effector of Akt/NF-κB signaling to modulate the progression and cisplatin-resistance in non-small cell lung cancer. Archives of Biochemistry and Biophysics, 108818. https://doi.org/10.1016/j.abb.2021.108818 Cite
Investigators tested the direct effect of triciribine on ACE2 expression in human bronchial (H441) and lung alveolar (A549) epithelial cells.
[Journal of Cellular Physiology]
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Scientists demonstrated that diacylglycerol kinase alpha (Dgka) mediated T-cell dysfunction during anti-PD-1 therapy by exacerbating the exhaustion of reinvigorated tumor-specific T cells.
[Cancer Immunology Research]
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Fu, L., Li, S., Xiao, W., Yu, K., Li, S., Yuan, S., Shen, J., Dong, X., Fang, Z., Zhang, J., Chen, S., Li, W., You, H., Xia, X., Kang, T., Tan, J., Chen, G., Yang, A.-K., Gao, Y., & Zhou, P. (2021). DGKA Mediates Resistance to PD-1 Blockade. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0216 Cite
Scientists modulated IRF4 levels by transfecting chronic lymphocytic leukemia cells with an IRF4 vector or by silencing using small-interfering RNAs.
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Exosomes were isolated from MSCs using ultracentrifugation, and further characterized by the nanoparticle tracking analyzer and flow cytometry. RNA sequencing, Western Blot, in vitro cell proliferation, in vivo pro-angiogenesis, as well as ischemic repairment of diabetic foot through rat model were performed to evaluate exosome physiological functions.
[Stem Cell Research]
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Huang, C., Luo, W., Wang, Q., Ye, Y., Fan, J., Lin, L., Shi, C., Wei, W., Chen, H., Wu, Y., & Tang, Y. (2021). Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p. Stem Cell Research, 52, 102235. https://doi.org/10.1016/j.scr.2021.102235 Cite
Scientists investigated whether fucoxanthinol (FxOH), induced apoptosis in human pancreatic cancer cells. FxOH significantly promoted the growth of human pancreatic cancer PANC-1 cells.
[Nutrition and Cancer]
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Terasaki, M., Takahashi, S., Nishimura, R., Kubota, A., Kojima, H., Ohta, T., Hamada, J., Kuramitsu, Y., Maeda, H., Miyashita, K., Takahashi, M., & Mutoh, M. (2021). A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. Nutrition and Cancer, 0(0), 1–16. https://doi.org/10.1080/01635581.2020.1863994 Cite
Researchers investigated the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow MSCs (BMSCs) following peroxidative damage and to explore the underlying mechanisms.
[Journal of Orthopaedic Surgery and Research]
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Liu, M., Ding, H., Wang, H., Wang, M., Wu, X., Gan, L., Cheng, L., & Li, X. (2021). Moringa oleifera leaf extracts protect BMSC osteogenic induction following peroxidative damage by activating the PI3K/Akt/Foxo1 pathway. Journal of Orthopaedic Surgery and Research, 16(1), 150. https://doi.org/10.1186/s13018-021-02284-x Cite