Tag Archives: AKT

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BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma

BRAF inhibitor induced BRAF-CRAF heterodimerization and subsequent activation of ERK signaling in cancer-associated fibroblasts, leading to inactivation of the β-catenin destruction complex.

[Cancer Research]

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Decursin Prevents Melanogenesis by Suppressing MITF Expression through the Regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β Cascades

Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.

[Biomedicine & Pharmacotherapy]

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Lycium barbarum Polysaccharide Antagonizes Cardiomyocyte Apoptosis by Inhibiting the Upregulation of GRK2 Induced by I/R Injury, and Salvage Mitochondrial Fission/Fusion Imbalance and AKT/eNOS Signaling

Scientists found that Lycium barbarum polysaccharide limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress.

[Cellular Signalling]

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The Inhibition of Panc1 Cancer Cells Invasion by hAMSCs Secretome through Suppression of Tyrosine Phosphorylation of SGK223 (at Y411 Site), C-src (at Y416, Y530 Sites), AKT Activity, and JAK1/Stat3 Signaling

Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.

[Medical Oncology]

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Oncogenic Potential of BEST4 in Colorectal Cancer via Activation of PI3K/Akt Signaling

BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. Scientists investigated the role and clinical significance of BEST4 in CRC.

[Oncogene]

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Caffeic Acid Phenethyl Ester Induces Radiosensitization via Inhibition of DNA Damage Repair in Androgen-Independent Prostate Cancer Cells

Investigators studied the effect of co-treatment of caffeic acid phenethyl ester (CAPE) and gamma radiation on androgen-independent DU145 and PC3 cells. The combination treatment sensitized prostate cancer cells to radiation in a dose-dependent manner. The radiosensitizing effect of CAPE was observed in both cell lines.

[Environmental Toxicology]

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CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma

Three metastasis-associated circRNAs identified in a previous circRNA-sequencing study were screened and validated in two hepatocellular carcinoma (HCC) cohorts. CircRPN2 was downregulated in highly metastatic HCC cell lines and HCC tissues with metastasis.

[Cancer Research]

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Sox9/CXCL5 Axis Facilitates Tumor Cell Growth and Invasion in Hepatocellular Carcinoma

Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.

[FEBS Journal]

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Pterostilbene Downregulates BCR/ABL and Induces Apoptosis of T315I-Mutated BCR/ABL-Positive Leukemic Cells

Scientists examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples obtained from patients with leukemia.

[Scientific Reports]

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Novel Inhibitor of Hematopoietic Cell Kinase as a Potential Therapeutic Agent for Acute Myeloid Leukemia

Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.

[Cancer Immunology Immunotherapy]

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