KARATE: PKA-Induced KRAS4B-RHOA-mTORC2 Supercomplex Phosphorylates AKT in Insulin Signaling and Glucose Homeostasis

By investigating insulin receptor signaling in human cells and biochemical reconstitution, scientists found that insulin induced the activation of mTORC2 toward AKT by assembling a supercomplex with KRAS4B and RHOA GTPases, termed KARATE (KRAS4B-RHOA-mTORC2 Ensemble).
[Molecular Cell]
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Chemerin Regulates Normal Angiogenesis and Hypoxia-Driven Neovascularization

Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning.
[Angiogenesis]
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RAS Induced Senescence of Skin Keratinocytes Is Mediated through Rho-Associated Protein Kinase (ROCK)

Researchers reported that the Rho-associated protein kinase (ROCK) signaling pathway was a critical regulator of oncogene-induced senescence in skin carcinogenesis.
[Molecular Carcinogenesis]
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Posttranslational Modifications by ADAM10 Shape Myeloid Antigen-Presenting Cell Homeostasis in the Splenic Marginal Zone

Scientists identified the cell-surface–expressed A-disintegrin-and-metalloproteinase 10 as an essential regulator of conventional dendritic cell (cDC)1 and cDC2 homeostasis in the splenic marginal zone.
[Proceedings of the National Academy of Sciences of the United States of America]
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Cell Polarity and Cell Adhesion Associated Gene Expression Differences between Invasive Micropapillary and No Special Type Breast Carcinomas and Their Prognostic Significance

Researchers analyzed mRNA expression profiles and the prognostic value of 43 genes involved in cell polarity, cell-adhesion and epithelial–mesenchymal transition in invasive micropapillary carcinoma of the breast tumors and compared them to invasive breast carcinomas of no special type.
[Scientific Reports]
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Asiatic Acid Alleviates Ischemic Myocardial Injury in Mice by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism

Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.
[Acta Pharmacologica Sinica]
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EMP3 Negatively Modulates Breast Cancer Cell DNA Replication, DNA Damage Repair, and Stem-Like Properties

In silico analysis showed that epithelial membrane protein 3 (EMP3) was associated with favorable survival, and negatively regulated cell cycle S-phase. Loss and gain of function studies demonstrated that EMP3 inhibited breast cancer cell S-phage entry, DNA replication, DNA damage repair, and stem-like properties.
[Cell Death & Disease]
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RecQ-Like Helicase 4 (RECQL4) Exacerbates Resistance to Oxaliplatin in Colon Adenocarcinoma via Activation of the PI3K/AKT Signaling Pathway

Researchers found RECQL4 was upregulated in colon adenocarcinoma (COAD), especially in Oxaliplatin-resistant COAD tissues and cells.
[Bioengineered]
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Tumor-Initiating Stem Cell Shapes Its Microenvironment into an Immunosuppressive Barrier and Pro-Tumorigenic Niche

Using DNA-label retaining, single-cell RNA sequencing, and other approaches, researchers investigated intestinal adenoma in response to chemoradiotherapy, thus identifying therapy-resistant tumor-initiating stem cells.
[Cell Reports]
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Pancreatic Cancer Cell-Derived MicroRNA-155-5p-Containing Extracellular Vesicles Promote Immune Evasion by Triggering EHF-Dependent Activation of Akt/NF-κB Signaling Pathway

Ectopic expression and knockdown experiments were conducted in pancreatic cancer (PC) cells, PC cells-derived EVs, or mouse xenograft model of PC.
[International Immunopharmacology]
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Potential Role of Epicardial Adipose Tissue in Coronary Artery Endothelial Cell Dysfunction in Type 2 Diabetes

To simulate type 2 diabetes-associated metabolic and inflammatory status in an ex vivo tissue culture model, human epicardial adipose tissue (EAT) samples were treated with a cocktail composed of high glucose, high palmitate, and lipopolysaccharide and were compared with control EAT.
[FASEB Journal]
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