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AKT

Hepatic Cell News

Emodin Suppresses Hepatocellular Carcinoma Growth by Regulating Macrophage Polarization via microRNA-26a/Transforming Growth Factor Beta 1/Protein Kinase B

[Bioengineered] After co-culture systems of M2 macrophages and HCC cells were established, it was shown that co-culture with M2 macrophages could promote both the proliferation and invasion of HepG2 and Huh7 cells.
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Prostate Cell News

Fraxetin Down-Regulates Polo-Like Kinase 4 (PLK4) to Inhibit Proliferation, Migration and Invasion of Prostate Cancer Cells through the Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B (Akt)...

[Bioengineered] The prostatic epithelial cell RWPE-1 and prostate cancer cell DU145 were exposed to Fraxetin to detect the changes in cell viability using cell counting kit-8 assay.
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Mammary Cell News

Circular RNA_0006014 Promotes Breast Cancer Progression through Sponging miR-885-3p to Regulate NTRK2 and PIK3/AKT Pathway

[Aging] qRT-PCR was used to detect the expression of circular RNA_0006014 (hsa_circ_0006014) and related genes. MTT, colony formation and Transwell assays were used to explore the potential biological functions of hsa_circ_0006014 in breast cancer cells.
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Mammary Cell News

JAC1 Targets YY1 Mediated JWA/p38 MAPK Signaling to Inhibit Proliferation and Induce Apoptosis in TNBC

[Cell Death Discovery] Researchers reported at the first time that JWA gene activating compound 1 (JAC1) inhibited the proliferation of TNBC in vitro and in vivo experimental models.
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Mammary Cell News

Overexpression of Multiple Epidermal Growth Factor Like Domains 11 Rescues Anoikis Survival through Tumor Cells-Platelet Interaction in Triple Negative Breast Cancer Cells

[Life Sciences] The role of multiple epidermal growth factor like domains 11 (MEGF11) was studied in human TNBC MDA-MB-231 and MDA-MB-468 cells by overexpressing MEGF11 using non-attached culture.
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Pulmonary Cell News

The miR-4732-5p/XPR1 Axis Suppresses the Invasion, Metastasis, and Epithelial–Mesenchymal Transition of Lung Adenocarcinoma via the PI3K/Akt/GSK3β/Snail Pathway

[Molecular Omics] Overexpression of miR-4732-5p significantly inhibited the migration, invasion, and metastasis of lung adenocarcinoma in vitro and in vivo, which could be reversed by overexpression of xenotropic and polytropic retrovirus receptor 1 (XPR1).
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