AKT

[Molecular Cancer Research] Investigators found that the acidic tumor microenvironment contributed to lipid accumulation in liver cancer by activating the PI3K/AKT signaling pathway and promoting SCD1-PPARα binding.

[Hepatology] The therapeutic efficacy and the molecular pathways targeted by TVB3664, either alone or with tyrosine kinase inhibitors or the checkpoint inhibitor anti-PD-L1 antibody, were assessed in human HCC cell lines and multiple oncogene-driven HCC mouse models.

[Science Advances] Scientists showed in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids that fasting improved sorafenib efficacy and acted synergistically to sensitize sorafenib-resistant HCC.

[Cellular Signalling] Scientists found that Lycium barbarum polysaccharide limited myocardial infarct size, improved adverse remodeling, and reduced cell death and oxidative stress.

[Medical Oncology] Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.

[Cancer Research] BRAF inhibitor induced BRAF-CRAF heterodimerization and subsequent activation of ERK signaling in cancer-associated fibroblasts, leading to inactivation of the β-catenin destruction complex.