AKT

[Cell Death & Disease] Scientists demonstrated that transmembrane protein (TMEM) 116 was highly expressed in NSCLC tissues and cell lines.

[Oncogene] The authors found that RGMA was downregulated in breast cancer (BC) tissues compared with non-tumorous breast tissues, particularly in metastatic BC samples, and that patients with low RGMA expression manifested a poorer prognosis.

[Molecules] Scientists investigated whether the autophagy inhibitor chloroquine could potentiate the anticancer effect of pterostilbene in the PDAC cell lines MIA PaCa-2 and BxPC-3, as well as in an orthotopic animal model.

[Cell Death Discovery] Researchers investigated the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer stem-like cells.

[Environmental Toxicology] Dysregulated miRNAs have been promulgated as oncogenes or tumor-suppressive genes participating in the initiation and progression of colorectal cancer (CRC). Scientists reported that miR-346 was highly expressed in CRC patients.

[Journal of Biomedical Science] The role of Receptor tyrosine kinase-like orphan receptor 2 (ROR2) in tumor growth was assessed in xenotransplantation experiments followed by immunohistochemistry analysis of the tumors.