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AKT

ISL1 Promotes Enzalutamide Resistance in Castration-Resistant Prostate Cancer (CRPC) through Epithelial to Mesenchymal Transition (EMT)

[Scientific Reports] The authors revealed the important role of insulin gene enhancer-binding protein 1 (ISL1) in androgen receptor (AR)-dependent prostate cancer cell growth; ISL1 knockdown reduced the AR activity and cell growth.

MET Inhibition Enhances PARP Inhibitor Efficacy in Castration-Resistant Prostate Cancer by Suppressing the ATM/ATR and PI3K/AKT Pathways

[Journal of Cellular and Molecular Medicine] Researchers demonstrated that mesenchymal–epithelial transition (MET) inhibition enhanced sensitivity of CRPC to poly adenosine diphosphate–ribose polymerase (PARP) inhibitors by suppressing the ATM/ATR and phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathways.

Cromolyn Platform Suppresses Fibrosis and Inflammation, Promotes Microglial Phagocytosis and Neurite Outgrowth

[Scientific Reports] Scientists utilized cromolyn, a mast cell inhibitor with anti-inflammatory capabilities, and its fluorinated analogue F-cromolyn to study fibrosis-related protein regulation and secretion downstream of neuroinflammation and their ability to promote microglial phagocytosis and neurite outgrowth.

Self-Renewal or Quiescence? Orchestrating the Fate of Mesenchymal Stem Cells by Matrix Viscoelasticity via PI3K/Akt-CDK1 Pathway

[Biomaterials] Researchers established an alginate hydrogel system with constant stiffness and tunable stress relaxation rate, which was a key parameter for the viscoelastic property of the material.

TCP1 Increases Drug Resistance in Acute Myeloid Leukemia by Suppressing Autophagy via Activating AKT/mTOR Signaling

[Cell Death & Disease] Scientists discovered that the T-complex protein 1 (TCP1) expression was elevated in acute myeloid leukemia patients and high TCP1 expression was associated with low complete response rate along with poor overall survival.

PEDF Is an Endogenous Inhibitor of VEGF-R2 Angiogenesis Signaling in Endothelial Cells

[Experimental Eye Research] Scientists showed that pigment epithelium derived factor (PEDF) prevented early mitogenic signals of vascular endothelial growth factor in primate retinal endothelial cells, blocking proliferation, migration and tube formation.

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