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AKT

Epicatechin Gallate Prevents the De Novo Synthesis of Fatty Acid and the Migration of Prostate Cancer Cells

[Acta Biochimica et Biophysica Sinica] Researchers evaluated the potential role of epicatechin gallate in prostate cancer cells and found that epicatechin gallate downregulated the expression of acetyl-CoA carboxylase, ATP citrate lyase, and fatty acid synthase in prostate cancer cells.

Cep55 Regulation of PI3K/Akt Signaling Is Required for Neocortical Development and Ciliogenesis

[PLoS Genetics] The elevated apoptosis of neural stem/progenitors was recapitulated using Cep55-deficient human cerebral organoids and investigators could rescue the phenotype by inhibiting active Gsk3β.

Fasting-Mimicking Diet Blocks Triple-Negative Breast Cancer and Cancer Stem Cell Escape

[Cell Metabolism] The authors reported that a fasting-mimicking diet activated starvation escape pathways in TNBC cells, which could be identified and targeted by drugs. They found that metastatic TNBC patients with lower glycemia survived longer than those with higher baseline glycemia.

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer

[Molecular Cancer Research] Scientists address the mechanistic progress on how PRK-like endoplasmic reticulum kinase (PERK) acts as a multifunctional molecule to commit 17β-estradiol to inducing apoptosis in endocrine-resistant breast cancer.

miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy

[Stem Cells International] Scientists investigated the efficacy of miR-20a overexpressing adipose-derived stem cell transplantation in murine lupus nephritis and explored potential molecular mechanisms.

CD157 Signaling Promotes Survival of Acute Myeloid Leukemia Cells and Modulates Sensitivity to Cytarabine through Regulation of Anti-apoptotic Mcl-1

[Scientific Reports] Investigators used peripheral blood and bone marrow samples from patients with acute myeloid leukemia (AML) to analyze the impact of CD157-directed antibodies in AML survival and in response to cytarabine ex vivo.

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