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AKT

CircETFA Upregulates CCL5 by Sponging miR-612 and Recruiting EIF4A3 to Promote Hepatocellular Carcinoma

[Cell Death Discovery] CircRNA microarray analysis was used to assess the plasma from hepatocellular carcinoma (HCC) patients and healthy controls and to identify circRNAs involved in HCC tumorigenesis.

MicroRNA-206 Promotes the Recruitment of CD8+ T Cells by Driving M1 Polarisation of Kupffer Cells

[Gut] FVB/NJ mice were hydrodynamically injected with AKT/Ras and Sleeping Beauty transposon to induce hepatocellular carcinoma. Mini-circle and Sleeping Beauty were used to overexpress microRNA-206 in Kupffer cells of mice.

Increased Abundance of Cbl E3 Ligases Alters PDGFR Signaling in Recessive Dystrophic Epidermolysis Bullosa

[Matrix Biology] Investigators indicated that elevated TGFβ signaling led to an attenuated response to growth factors, which contributed to impaired dermal wound healing in recessive dystrophic epidermolysis bullosa.

Akt-Mediated Ephexin1–Ras Interaction Promotes Oncogenic Ras Signaling and Colorectal and Lung Cancer Cell Proliferation

[Cell Death & Disease] Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. The authors showed that Ephexin1 was highly expressed in colorectal cancer and lung cancer patient tissues.

Comparison of the Cytokine Profile in Mesenchymal Stem Cells from Human Adipose, Umbilical Cord, and Placental Tissues

[Cellular Reprogramming] MSCs were extracted from adipose, umbilical cord, and placental tissues. The expression levels of 80 cytokines were detected, and the data demonstrated that the three MSC types abundantly secreted insulin-like growth factor-binding protein (IGFBP)-4, IGFBP-3, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, IGFBP-6, monocyte chemoattractant protein-1, and granulocyte colony-stimulating factor.

The Androgen Receptor—lncRNASAT1-AKT-p15 Axis Mediates Androgen-Induced Cellular Senescence in Prostate Cancer Cells

[Oncogene] Investigators analyzed the underlying molecular pathway and revealed that supraphysiological androgen levels induced cellular senescence in both, castration-sensitive LNCaP and castration-resistant prostate cancer C4-2 cells through the cell cycle inhibitor p15INK4b and increased phosphorylation of AKT.

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